Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Alex Pell"'
Autor:
Bingchuan Wei, Nicholas Woon, Lu Dai, Raphael Fish, Michelle Tai, Winode Handagama, Ashley Yin, Jia Sun, Andrew Maier, Dana McDaniel, Elvira Kadaub, Jessica Yang, Miguel Saggu, Ann Woys, Oxana Pester, Danny Lambert, Alex Pell, Zhiqi Hao, Gordon Magill, Jack Yim, Jefferson Chan, Lindsay Yang, Frank Macchi, Christian Bell, Galahad Deperalta, Yan Chen
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Rapid release of biopharmaceutical products enables a more efficient drug manufacturing process. Multi-attribute methods that target several product quality attributes (PQAs) at one time are an essential pillar of the rapid-release strategy. The nove
Externí odkaz:
https://doaj.org/article/35d74feefc4744f0aa083c2c0827e7e8
Autor:
Bingchuan Wei, Nicholas Woon, Lu Dai, Raphael Fish, Michelle Tai, Winode Handagama, Ashley Yin, Jia Sun, Andrew Maier, Dana McDaniel, Elvira Kadaub, Jessica Yang, Miguel Saggu, Ann Woys, Oxana Pester, Danny Lambert, Alex Pell, Zhiqi Hao, Gordon Magill, Jack Yim, Jefferson Chan, Lindsay Yang, Frank Macchi, Christian Bell, Galahad Deperalta, Yan Chen
Publikováno v:
mAbs
article-version (VoR) Version of Record
mAbs, Vol 14, Iss 1 (2022)
article-version (VoR) Version of Record
mAbs, Vol 14, Iss 1 (2022)
Rapid release of biopharmaceutical products enables a more efficient drug manufacturing process. Multi-attribute methods that target several product quality attributes (PQAs) at one time are an essential pillar of the rapid-release strategy. The nove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb5a730114fbc81497f1e82415fb3966
https://doi.org/10.1080/19420862.2021.2007564
https://doi.org/10.1080/19420862.2021.2007564
Autor:
Matthew Stuible, Joseph D. Schrag, Joey Sheff, Daria Zoubchenok, Simon Lord-Dufour, Brian Cass, Denis L’Abbé, Alex Pelletier, Martin A. Rossotti, Jamshid Tanha, Christian Gervais, Roger Maurice, Majida El Bakkouri, Mauro Acchione, Yves Durocher
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract SARS-CoV-2 subunit vaccines continue to be the focus of intense clinical development worldwide. Protein antigens in these vaccines most commonly consist of the spike ectodomain fused to a heterologous trimerization sequence, designed to mimi
Externí odkaz:
https://doaj.org/article/dc399963cdec43a6ac763c16fa63044f
Autor:
Catherine Forest-Nault, Izel Koyuturk, Jimmy Gaudreault, Alex Pelletier, Denis L’Abbé, Brian Cass, Louis Bisson, Alina Burlacu, Laurence Delafosse, Matthew Stuible, Olivier Henry, Gregory De Crescenzo, Yves Durocher
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Several key mutations in the Spike protein receptor binding domain (RBD) have been identified to influence its affinity for the human Angiotensin-Converting Enzyme 2 (ACE2). Here, we perform a comparative study of the ACE2 binding to the wil
Externí odkaz:
https://doaj.org/article/13bedb88d258407e8f1a229ff39ec266
Autor:
Alex Pellerin, Kei Yasuda, Abraham Cohen-Bucay, Vanessa Sandra, Prachi Shukla, Barry K. Horne Jr, Kerstin Nündel, Gregory A. Viglianti, Yao Xie, Ulf Klein, Ying Tan, Ramon G. Bonegio, Ian R. Rifkin
Publikováno v:
JCI Insight, Vol 6, Iss 15 (2021)
Gain-of-function polymorphisms in the transcription factor IFN regulatory factor 5 (IRF5) are associated with an increased risk of developing systemic lupus erythematosus. However, the IRF5-expressing cell type(s) responsible for lupus pathogenesis i
Externí odkaz:
https://doaj.org/article/2e3d24d4d4304cf39a01f33fd1604a1e
Autor:
Eris Bame, Hao Tang, Jeremy C Burns, Million Arefayene, Klaus Michelsen, Bin Ma, Isaac Marx, Robin Prince, Allie M Roach, Urjana Poreci, Douglas Donaldson, Patrick Cullen, Fergal Casey, Jing Zhu, Thomas M Carlile, Dipen Sangurdekar, Baohong Zhang, Patrick Trapa, Joseph Santoro, Param Muragan, Alex Pellerin, Stephen Rubino, Davide Gianni, Bekim Bajrami, Xiaomei Peng, Alex Coppell, Katherine Riester, Shibeshih Belachew, Devangi Mehta, Mike Palte, Brian T Hopkins, Matthew Scaramozza, Nathalie Franchimont, Michael Mingueneau
Publikováno v:
Clinical & Translational Immunology, Vol 10, Iss 6, Pp n/a-n/a (2021)
Abstract Objectives Bruton's tyrosine kinase (BTK) plays a non‐redundant signaling role downstream of the B‐cell receptor (BCR) in B cells and the receptors for the Fc region of immunoglobulins (FcR) in myeloid cells. Here, we characterise BIIB09
Externí odkaz:
https://doaj.org/article/960649d0c0f948e3add268a6d5cc0401
Autor:
Anne E.G. Lenferink, Paul C. McDonald, Christiane Cantin, Suzanne Grothé, Mylene Gosselin, Jason Baardsnes, Myriam Banville, Paul Lachance, Alma Robert, Yuneivy Cepero-Donates, Stevo Radinovic, Patrick Salois, Marie Parat, Hafida Oamari, Annie Dulude, Mehul Patel, Martin Lafrance, Andrea Acel, Nathalie Bousquet-Gagnon, Denis L’Abbé, Alex Pelletier, Félix Malenfant, Maria Jaramillo, Maureen O’Connor-Mccourt, Cunle Wu, Yves Durocher, Mélanie Duchesne, Christine Gadoury, Anne Marcil, Yves Fortin, Beatrice Paul-Roc, Maurizio Acchione, Shawn C. Chafe, Oksana Nemirovsky, Joseph Lau, Francois Bénard, Shoukat Dedhar
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
The architectural complexity and heterogeneity of the tumor microenvironment (TME) remains a substantial obstacle in the successful treatment of cancer. Hypoxia, caused by insufficient oxygen supply, and acidosis, resulting from the expulsion of acid
Externí odkaz:
https://doaj.org/article/a78bd5c3c72d4143937f4cd8eec87eef
Autor:
Joey G. Sheff, John F. Kelly, Anna Robotham, Traian Sulea, Félix Malenfant, Denis L’Abbé, Mélanie Duchesne, Alex Pelletier, Jean Lefebvre, Andrea Acel, Marie Parat, Mylene Gosselin, Cunle Wu, Yves Fortin, Jason Baardsnes, Henk Van Faassen, Shannon Awrey, Shawn C. Chafe, Paul C. McDonald, Shoukat Dedhar, Anne E.G. Lenferink
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Human carbonic anhydrase (hCAIX), an extracellular enzyme that catalyzes the reversible hydration of CO2, is often overexpressed in solid tumors. This enzyme is instrumental in maintaining the survival of cancer cells in a hypoxic and acidic tumor mi
Externí odkaz:
https://doaj.org/article/05ceb9ddaa0e4ba48f2d8c3227f954cc