Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Alex Pasternak"'
Autor:
Angelica Van Goor, Alex Pasternak, Muhammed Walugembe, Nadya Chehab, Glenn Hamonic, Jack C. M. Dekkers, John C. S. Harding, Joan K. Lunney
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Introduction: Porcine reproductive and respiratory syndrome virus (PRRSV) causes respiratory disease in piglets and reproductive disease in sows. Piglet and fetal serum thyroid hormone (i.e., T3 and T4) levels decrease rapidly in response to Porcine
Externí odkaz:
https://doaj.org/article/13c44dd9e0e149c5a87bfaab582323de
Autor:
Angelica Van Goor, Alex Pasternak, Kristen Walker, Linjun Hong, Carolina Malgarin, Daniel J. MacPhee, John C. S. Harding, Joan K. Lunney
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-20 (2020)
Abstract Background A pregnant gilt infected with porcine reproductive and respiratory syndrome virus (PRRSV) can transmit the virus to her fetuses across the maternal-fetal-interface resulting in varying disease outcomes. However, the mechanisms lea
Externí odkaz:
https://doaj.org/article/fe0ec609ca9d4893869452891c394160
Autor:
Margaret K. Mulligan, Jocelyn E. Kleiman, Andrew C. Caldemeyer, John C. S. Harding, J. Alex Pasternak
Publikováno v:
Veterinary Research, Vol 53, Iss 1, Pp 1-14 (2022)
Abstract Porcine reproductive and respiratory syndrome virus (PRRSV) infection during late gestation negatively affects fetal development. The objective of this study was to identify the fetal organs most severely impacted following infection, and ev
Externí odkaz:
https://doaj.org/article/5eb7e90db1814ed9b34dd99b52d8f9c7
Autor:
Carolina M. Malgarin, Fiona Moser, J. Alex Pasternak, Glenn Hamonic, Susan E. Detmer, Daniel J. MacPhee, John C. S. Harding
Publikováno v:
BMC Veterinary Research, Vol 17, Iss 1, Pp 1-14 (2021)
Abstract Background Mechanisms of fetal death following maternal PRRSV2 infection remain uncharacterized, although hypoxia from umbilical cord lesions and/or placental detachment due to apoptosis are hypothesized. We performed two experiments examini
Externí odkaz:
https://doaj.org/article/4302054c76e943c1aeec65c40821b847
Publikováno v:
Veterinary Research, Vol 51, Iss 1, Pp 1-14 (2020)
Abstract To better understand the host response to porcine reproductive and respiratory virus-2 (PRRSV2) we evaluated circulating thyroid hormone and associated gene expression in a late gestation challenge model. Pregnant gilts were inoculated at ge
Externí odkaz:
https://doaj.org/article/3aecafb3eb2f4cee87019f9eec6c78be
Autor:
Glenn Hamonic, J. Alex Pasternak, Siew Hon Ng, Kezia R. Fourie, Olena M. Simko, Brodie Deluco, Heather L. Wilson
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
To protect the health of sows and gilts, significant investments are directed toward the development of vaccines against infectious agents that impact reproduction. We developed an intrauterine vaccine that can be delivered with semen during artifici
Externí odkaz:
https://doaj.org/article/9029b57b55cb4a31bd8b6da904021845
Autor:
Javier A. Barrera-Zarate, Susan E. Detmer, J. Alex Pasternak, Glenn Hamonic, Daniel J. MacPhee, John C. S. Harding
Publikováno v:
Veterinary Pathology. 59:940-949
Angiogenesis and cell proliferation in reproductive tissues are essential events for the maintenance of pregnancy, and alterations can lead to compromised fetal development and survival. Porcine reproductive and respiratory syndrome virus 2 (PRRSV-2)
Publikováno v:
Theriogenology. 184:162-170
Understanding why intrauterine growth restricted (IUGR) fetuses are more resilient to transplacental porcine reproductive and respiratory syndrome virus-2 (PRRSV-2) infection compared to normal fetuses may lead to alternative approaches to control PR
Autor:
Leah Thompson, J. Alex Pasternak, Ramjee Ghimire, D. Hashini Galhena Dissanayake, Nanda Joshi, Waleed Saleh, Paul Ebner
Publikováno v:
Journal of International Agricultural and Extension Education. 28:6-22
Publikováno v:
Veterinary research. 53(1)
Porcine reproductive and respiratory syndrome virus (PRRSV) in late gestation causes a profound suppression of circulating maternal and fetal thyroid hormone during a critical window of development. To understand this relationship, we evaluated thyro