Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Alex Pasternak"'
Publikováno v:
BMC Veterinary Research, Vol 20, Iss 1, Pp 1-13 (2024)
Abstract Background Hypothyroidism is a common endocrine disruption observed in utero that adversely affects fetal growth and maturation leading to long-term impacts on health; however, the exact molecular mechanisms by which these deleterious effect
Externí odkaz:
https://doaj.org/article/29f84585258641c3b5f3779b76c679d1
Autor:
Haesu Ko, J. Alex Pasternak, Margaret K. Mulligan, Glenn Hamonic, Naresh Ramesh, Daniel J. MacPhee, Graham S. Plastow, John C. S. Harding
Publikováno v:
BMC Veterinary Research, Vol 20, Iss 1, Pp 1-16 (2024)
Abstract Background Porcine reproductive and respiratory syndrome virus 2 (PRRSV-2) infection during late gestation substantially lowers fetal viability and survival. In a previous genome-wide association study, a single nucleotide polymorphism on ch
Externí odkaz:
https://doaj.org/article/58c5c4b33127490a98036b3ecad2030e
Publikováno v:
Physiological Reports, Vol 12, Iss 8, Pp n/a-n/a (2024)
Abstract Thyroid hormones regulate metabolic rate, nutrient utilization, growth, and development. Swine are susceptible to thyroid suppression in response to disease or environmental conditions, but the physiological impact of such disruption has not
Externí odkaz:
https://doaj.org/article/6f01a56d49034df1a665acc09bf6ee89
Publikováno v:
Veterinary Research, Vol 53, Iss 1, Pp 1-14 (2022)
Abstract Porcine reproductive and respiratory syndrome virus (PRRSV) in late gestation causes a profound suppression of circulating maternal and fetal thyroid hormone during a critical window of development. To understand this relationship, we evalua
Externí odkaz:
https://doaj.org/article/0d1144fbd79b4957971c7f356aaca7cd
Autor:
Angelica Van Goor, Alex Pasternak, Muhammed Walugembe, Nadya Chehab, Glenn Hamonic, Jack C. M. Dekkers, John C. S. Harding, Joan K. Lunney
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Introduction: Porcine reproductive and respiratory syndrome virus (PRRSV) causes respiratory disease in piglets and reproductive disease in sows. Piglet and fetal serum thyroid hormone (i.e., T3 and T4) levels decrease rapidly in response to Porcine
Externí odkaz:
https://doaj.org/article/13c44dd9e0e149c5a87bfaab582323de
Autor:
Margaret K. Mulligan, Jocelyn E. Kleiman, Andrew C. Caldemeyer, John C. S. Harding, J. Alex Pasternak
Publikováno v:
Veterinary Research, Vol 53, Iss 1, Pp 1-14 (2022)
Abstract Porcine reproductive and respiratory syndrome virus (PRRSV) infection during late gestation negatively affects fetal development. The objective of this study was to identify the fetal organs most severely impacted following infection, and ev
Externí odkaz:
https://doaj.org/article/5eb7e90db1814ed9b34dd99b52d8f9c7
Autor:
Carolina M. Malgarin, Fiona Moser, J. Alex Pasternak, Glenn Hamonic, Susan E. Detmer, Daniel J. MacPhee, John C. S. Harding
Publikováno v:
BMC Veterinary Research, Vol 17, Iss 1, Pp 1-14 (2021)
Abstract Background Mechanisms of fetal death following maternal PRRSV2 infection remain uncharacterized, although hypoxia from umbilical cord lesions and/or placental detachment due to apoptosis are hypothesized. We performed two experiments examini
Externí odkaz:
https://doaj.org/article/4302054c76e943c1aeec65c40821b847
Autor:
Angelica Van Goor, Alex Pasternak, Kristen Walker, Linjun Hong, Carolina Malgarin, Daniel J. MacPhee, John C. S. Harding, Joan K. Lunney
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-20 (2020)
Abstract Background A pregnant gilt infected with porcine reproductive and respiratory syndrome virus (PRRSV) can transmit the virus to her fetuses across the maternal-fetal-interface resulting in varying disease outcomes. However, the mechanisms lea
Externí odkaz:
https://doaj.org/article/fe0ec609ca9d4893869452891c394160
Publikováno v:
Veterinary Research, Vol 51, Iss 1, Pp 1-14 (2020)
Abstract To better understand the host response to porcine reproductive and respiratory virus-2 (PRRSV2) we evaluated circulating thyroid hormone and associated gene expression in a late gestation challenge model. Pregnant gilts were inoculated at ge
Externí odkaz:
https://doaj.org/article/3aecafb3eb2f4cee87019f9eec6c78be
Autor:
Glenn Hamonic, J. Alex Pasternak, Siew Hon Ng, Kezia R. Fourie, Olena M. Simko, Brodie Deluco, Heather L. Wilson
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
To protect the health of sows and gilts, significant investments are directed toward the development of vaccines against infectious agents that impact reproduction. We developed an intrauterine vaccine that can be delivered with semen during artifici
Externí odkaz:
https://doaj.org/article/9029b57b55cb4a31bd8b6da904021845