Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Alex P. Praseuth"'
Publikováno v:
Biotechnology Progress. 24:1226-1231
Streptomyces triostinicus produces triostin A, an antitumor antibiotic, as its major secondary metabolite. Surprisingly, this strain also produced a trace amount of echinomycin. We sequenced the entire triostin A biosynthetic gene cluster from S. tri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61354fd1da7ea8ec9c695dc5c53709f1
https://doi.org/10.1002/btpr.34
https://doi.org/10.1002/btpr.34
Autor:
James F. Sanchez, Berl R. Oakley, Ashley D. Davidson, Edyta Szewczyk, Hsien-Chun Lo, Clay C. C. Wang, Hagop Simityan, Yi-Ming Chiang, Alex P. Praseuth, Eric J. Kuo, Wen-Yueh Ho, Tania Nayak, Kenji Watanabe
Publikováno v:
Chemistry & Biology. 15(6):527-532
SummaryThe recently sequenced genomes of several Aspergillus species have revealed that these organisms have the potential to produce a surprisingly large range of natural products, many of which are currently unknown. We have found that A. nidulans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e624786e8c450fc40e9bcccd620d7a0
Autor:
Hideaki Oikawa, Alex P. Praseuth, Clay C. C. Wang, Hiroki Oguri, Kenji Watanabe, Mike B. Praseuth
Publikováno v:
Biotechnology Progress. 24:134-139
Proficient production of the antitumor agent triostin A was developed using engineered Escherichia coli (E. coli). The bacterium played host to 15 genes that encode integral biosynthetic proteins which were identified and cloned from Streptomyces las
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76b3d83249d45156b096b84aa8accb31
https://doi.org/10.1021/bp070298y
https://doi.org/10.1021/bp070298y
Autor:
Takayoshi Saruwatari, Hiroshi Noguchi, Kohei Torikai, Michio Sato, Kenji Watanabe, Alex P. Praseuth
Publikováno v:
ChemInform. 42
Fungal polyketide synthases (PKSs) catalyze a carbon-carbon bond forming reaction in an iterative manner using a variety of acyl-CoA molecules as substrates when biosynthesizing complex polyketides. Although most members from this class of natural pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a7d6e88be83fc93505079373994a210
https://doi.org/10.1002/chin.201120262
https://doi.org/10.1002/chin.201120262
Autor:
Hiroki Oguri, Clay C. C. Wang, Hideaki Oikawa, Mark Searcey, Kinya Hotta, Alex P. Praseuth, Kenji Watanabe
Drugs from bugs . We have successfully expanded the scope of our E. coli-based total biosynthesis of natural products and their analogues by rationally engineering the echinomycin biosynthesis pathway for the production of a synthetic analogue of tri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1550d6f0d87f2830d5581a98b2d57089
https://europepmc.org/articles/PMC4556348/
https://europepmc.org/articles/PMC4556348/
Autor:
Kenji Watanabe, Alex P. Praseuth, Kinya Hotta, Clay C. C. Wang, Daiki Inada, Kosaku Takahashi, Eri Fukushi, Mino Nakaya, Hideaki Oikawa, Hiroki Oguri
Publikováno v:
Journal of the American Chemical Society. 131(26)
Natural products display impressive activities against a wide range of targets, including viruses, microbes and tumors. However, their clinical use is hampered frequently by their scarcity and undesirable toxicity. Not only can engineering Escherichi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26a5dac91e7d1a33a4bc9007518b988a
https://pubmed.ncbi.nlm.nih.gov/19514719
https://pubmed.ncbi.nlm.nih.gov/19514719
Publikováno v:
Methods in enzymology. 458
Nonribosomal peptides (NRPs) are synthesized by modular mega-enzymes called NRP synthetases (NRPSs) that catalyze a peptide bond-forming reaction using natural amino acids as substrates. Most members of this class of natural products exhibit remarkab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3a8a505e35d07bdb455f4c84fd7e71b3
https://pubmed.ncbi.nlm.nih.gov/19374991
https://pubmed.ncbi.nlm.nih.gov/19374991
Nonribosomal peptides (NRPs) are synthesized by modular mega‐enzymes called NRP synthetases (NRPSs) that catalyze a peptide bond‐forming reaction using natural amino acids as substrates. Most members of this class of natural products exhibit rema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cec5367bab371eea498a91ed634160ff
https://doi.org/10.1016/s0076-6879(09)04815-0
https://doi.org/10.1016/s0076-6879(09)04815-0
Publikováno v:
Current opinion in chemical biology. 11(3)
Customizing biosynthesis of natural products to yield biologically active derivatives has captivated scientists in the field of biosynthetic research. To substantiate this goal, there are scores of obstacles to consider. To create novel metabolites b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95b09366e57e3bcf5314f119bb003a4c
https://pubmed.ncbi.nlm.nih.gov/17482864
https://pubmed.ncbi.nlm.nih.gov/17482864
Autor:
Kento Koketsu, Kenji Watanabe, Clay C. C. Wang, Kinya Hotta, Akira Migita, Hideaki Oikawa, Alex P. Praseuth, Christopher N. Boddy, Hiroki Oguri
Publikováno v:
Nature chemical biology. 2(8)
Nonribosomal peptides (NRPs) are a class of microbial secondary metabolites that have a wide variety of medicinally important biological activities, such as antibiotic (vancomycin), immunosuppressive (cyclosporin A), antiviral (luzopeptin A) and anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79b9479d5018863082c172a929867993
https://pubmed.ncbi.nlm.nih.gov/16850013
https://pubmed.ncbi.nlm.nih.gov/16850013