Complications of miliary tuberculosis: low mortality and predictive biomarkers from a UK cohort

Autor: Jonathan Underwood, Fiona Cresswell, Alex P Salam, Alex J Keeley, Charles Cleland, Laurence John, Robert N Davidson

Publikováno v: BMC Infectious Diseases, Vol 17, Iss 1, Pp 1-7 (2017)

Abstract Background Untreated, miliary tuberculosis (TB) has a mortality approaching 100%. As it is uncommon there is little specific data to guide its management. We report detailed data from a UK cohort of patients with miliary tuberculosis and the

Externí odkaz: https://doaj.org/article/b1d6c4de83e54b1bb333c9c7772d731e

Lack of Evidence for Ribavirin Treatment of Lassa Fever in Systematic Review of Published and Unpublished Studies

Autor: Hung-Yuan Cheng, Clare E. French, Alex P. Salam, Sarah Dawson, Alexandra McAleenan, Luke A. McGuinness, Jelena Savović, Peter W. Horby, Jonathan A.C. Sterne

Publikováno v: Emerging Infectious Diseases, Vol 28, Iss 8, Pp 1559-1568 (2022)

Ribavirin has been used widely to treat Lassa fever in West Africa since the 1980s. However, few studies have systematically appraised the evidence for its use. We conducted a systematic review of published and unpublished literature retrieved from e

Externí odkaz: https://doaj.org/article/82bcbe709fa247f9b513e6c5dc7b253b

A standardised Phase III clinical trial framework to assess therapeutic interventions for Lassa fever.

Autor: Adebola Tolulope Olayinka, Josephine Bourner, George O Akpede, Joseph Okoeguale, Chukwuyem Abejegah, Nnennaya A Ajayi, Christian Akude, Oluwafemi Ayodeji, Daniel G Bausch, Hilde de Clerck, Chioma Dan-Nwafor, Jake Dunning, Cyril Erameh, Justus Ndulue Eze, Pierre Formenty, Annelies Gillesen, Sulaiman Jalloh, Marie Jaspard, Tolulope Jegede, Jacob Maikere, Denis Malvy, Ephraim Ogbaini-Emovon, Olalekan Ezekial Ojo, Sylvanus Okogbenin, Kwame O'Neill, Maria-Lauretta Orji, Sampson Omagbemi Owhin, Michael Ramharter, Robert J Samuels, Nathan Shehu, Laura Merson, Alex Paddy Salam, Nzelle Delphine Kayem, Peter Horby, Chikwe Ihekweazu, Piero Olliaro

Publikováno v: PLoS Neglected Tropical Diseases, Vol 16, Iss 1, p e0010089 (2022)

BackgroundOnly one recommendation currently exists for the treatment of Lassa fever (LF), which is ribavirin administered in conjunction with supportive care. This recommendation is primarily based on evidence generated from a single clinical trial t

Externí odkaz: https://doaj.org/article/b60018e400ac4403b5581934cbaa9fe3

Lassa fever outcomes and prognostic factors in Nigeria (LASCOPE): a prospective cohort study

Autor: Claire Levy-Marchal, Jackson Katembo Vihundira, Sampson Omagbemi Owhin, Marion Bérerd-Camara, Justine Schaeffer, Sophie Duraffour, Johnson Etafo, Alex P. Salam, Chukwuyem Abejegah, Adewale Oladayo Akinpelu, Alexandre Duvignaud, Delphine Gabillard, Camille le Gal, Josephine Funmilola Alabi, Peter Horby, Kader Issaley, Abiodun Tolani Abidoye, Eric Ouattara, Moronke Uzuajemeh Ireneh, Denis Malvy, Liasu Adeagbo Ahmed, Ijeoma Chukwudumebi Etafo, Mahamadou Doutchi, Olufunke Gbenga-Ayeni, Benjamin Séri, Irmine Ahyi, Moses Adeniyi Adedokun, Ephraim Ogbaini-Emovon, Kehinde Gbemisola Fadiminiyi, Oyebimpe Ope Oyegunle, Akinola Nelson Adedosu, Ayoleyi Omowunmi Dede, Jean-Paul de Bruyne Mushenvula, Patience Iziegbe Ehigbor, Elvis Amani, Nicolas Danet, Titilola Deborah Sule, Marie Jaspard, Mamoudou Diabaté, B. Serra, Bertine Siloué, Stephan Günther, Augustin Augier, Larissa N'guessan-Koffi, Sophie Karcher, Oladele Oluwafemi Ayodeji, Xavier Anglaret, Macdonald Nonso Onyechi

Publikováno v: The Lancet global health
The Lancet global health, Elsevier, 2021, 9 (4), pp.e469-e478. ⟨10.1016/s2214-109x(20)30518-0⟩
The Lancet. Global Health

Summary Background Lassa fever is a viral haemorrhagic fever endemic in parts of west Africa. New treatments are needed to decrease mortality, but pretrial reference data on the disease characteristics are scarce. We aimed to document baseline charac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::690d4f0ac9faee8d5024bfd2f8edbc3a
https://doi.org/10.1016/s2214-109x(20)30518-0

Factors Influencing Atypical Clinical Presentations during the 2017 Madagascar Pneumonic Plague Outbreak: A Prospective Cohort Study

Autor: Rindra Randremanana, Reziky Tiandraza Mangahasimbola, Rodrigue N. E. Hasiniatsy, Dominique Razafimandimby, Tiana Razafinambinintsoa, Anna L. Funk, Laurence Baril, Andrew M. Lovering, Randrianirina Frédérique, Minoarisoa Rajerison, Alex P. Salam, Arnaud Fontanet, Mihaja Raberahona, Faraniaina Andrianarintsiferantsoa, Mamy Jean de Dieu Randria, Norosoa Harline Razanajatovo, Voahangy Andrianaivoarimanana, Peter Horby, Eric Bertherat, Prisca Andriantsalama, Rado Rakotomalala, Jean-Michel Heraud, Lyndsey Castle, Bertrand Renaud, Liam Read

Publikováno v: American Journal of Tropical Medicine and Hygiene
American Journal of Tropical Medicine and Hygiene, 2020, 102 (6), pp.1309-1315. ⟨10.4269/ajtmh.19-0576⟩
American Journal of Tropical Medicine and Hygiene, American Society of Tropical Medicine and Hygiene, 2020, 102 (6), pp.1309-1315. ⟨10.4269/ajtmh.19-0576⟩
The American Journal of Tropical Medicine and Hygiene

International audience; In late 2017, Madagascar experienced a large urban outbreak of pneumonic plague, the largest outbreak to date this century. During the outbreak, there were widespread reports of plague patients presenting with atypical symptom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24b0c5a0d85f93d29a15dae8fa1cfded
https://doi.org/10.4269/ajtmh.19-0576