Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Alex P, Young"'
Autor:
Paulina M. Getsy, Walter J. May, Alex P. Young, Santhosh M. Baby, Gregory A. Coffee, James N. Bates, Yee-Hsee Hsieh, Stephen J. Lewis
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Our lab is investigating the efficacy profiles of tropine analogs against opioid-induced respiratory depression. The companion manuscript reports that the cell-permeant tropeine, tropine ester (Ibutropin), produces a rapid and sustained reversal of t
Externí odkaz:
https://doaj.org/article/206aecfd4bd54baca01b5da85e16ff77
Autor:
Grace Branjerdporn, Kerri Gillespie, Elizabeth Martin, Vivianne Kissane, Alex De Young, Tatjana Ewais, Kathleen Goldsmith, Susan Wilson, Sam Adhikary, Greg McGahan, Constanze Schulz, Michael Beckmann
Publikováno v:
Trials, Vol 24, Iss 1, Pp 1-11 (2023)
Abstract Background Perinatal women are highly vulnerable to developing mental health issues and particularly susceptible to a recurrence of psychiatric illness. Poor mental health during the perinatal period can have long-term impacts on the physica
Externí odkaz:
https://doaj.org/article/86b6f0315eed4263ad6d2ec10403b06e
Autor:
Benjamin Gaston, Santhosh M. Baby, Walter J. May, Alex P. Young, Alan Grossfield, James N. Bates, James M. Seckler, Christopher G. Wilson, Stephen J. Lewis
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract We have identified thiolesters that reverse the negative effects of opioids on breathing without compromising antinociception. Here we report the effects of d-cystine diethyl ester (d-cystine diEE) or d-cystine dimethyl ester (d-cystine diME
Externí odkaz:
https://doaj.org/article/41ace98fd93a40d48fca5e4e1a53a813
Autor:
Michael W. Jenkins, Faiza Khalid, Santhosh M. Baby, Walter J. May, Alex P. Young, James N. Bates, Feixiong Cheng, James M. Seckler, Stephen J. Lewis
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract There is an urgent need to develop novel compounds that prevent the deleterious effects of opioids such as fentanyl on minute ventilation while, if possible, preserving the analgesic actions of the opioids. We report that L-glutathione ethyl
Externí odkaz:
https://doaj.org/article/e8f4803ec10a4a88badb5c1309e08a21
Autor:
Paulina M. Getsy, Santhosh M. Baby, Walter J. May, Alex P. Young, Benjamin Gaston, Matthew R. Hodges, Hubert V. Forster, James N. Bates, Christopher G. Wilson, Tristan H. J. Lewis, Yee-Hee Hsieh, Stephen J. Lewis
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Cell-penetrant thiol esters including the disulfides, D-cystine diethyl ester and D-cystine dimethyl ester, and the monosulfide, L-glutathione ethyl ester, prevent and/or reverse the deleterious effects of opioids, such as morphine and fentanyl, on b
Externí odkaz:
https://doaj.org/article/498c8bb8e48f4686a17a66cbccf872fb
Publikováno v:
European Journal of Psychotraumatology, Vol 12, Iss 1 (2021)
Background: The COVID-19 pandemic and its consequences are stressful for many children and their families. Previous research with school-aged children has shown that negative thoughts and worries can predict mental health symptoms following stressful
Externí odkaz:
https://doaj.org/article/47bc3a23a8b243cb80a6e009f228ac23
Autor:
Lindsay Livingston, Alex Trimble Young
Publikováno v:
Lateral, Vol 9, Iss 1 (2020)
This introduction examines gun culture in the United States and argues that it is a product of the longstanding practices of settler colonialism, anti-Blackness, and misogyny that have shaped life in the United States. Invoking an anthropological def
Externí odkaz:
https://doaj.org/article/724c687e814647efbdf1b26dbc32b754
Autor:
Alex Trimble Young
Publikováno v:
Lateral, Vol 9, Iss 1 (2020)
This article approaches the speculative fiction of the survivalist right as an archive that can illuminate the continuities between the fantasies of necropolitical power that animate the radical right and undergird the sovereignty of the United State
Externí odkaz:
https://doaj.org/article/d1bcb7606eaf4d2db25c6170b41de2e5
Publikováno v:
Animals, Vol 11, Iss 12, p 3366 (2021)
(1) Background: Parasagittal groove (PSG) changes are often present on advanced imaging of racing Thoroughbred fetlocks and have been suggested to indicate increased fracture risk. Currently, there is limited evidence differentiating the imaging appe
Externí odkaz:
https://doaj.org/article/1c0017e5529948bfa996ddbd21cf84f8
Publikováno v:
Energies, Vol 14, Iss 20, p 6696 (2021)
Opposed-piston, two-stroke engines reveal degrees of freedom that make them excellent candidates for next generation, highly efficient internal combustion engines for hybrid electric vehicles and power systems. This article reports simulation results
Externí odkaz:
https://doaj.org/article/6cb68d2033d3413ebc208077063771b9