Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Alex Nie"'
Autor:
Dhammika Amaratunga, Komal S. Sandhu, Michael K. McMillian, Peter Lord, Alex Nie, Geert R. Verheyen, Xiang Yao, Vamsi Veeramachaneni
Publikováno v:
Pharmacogenomics. 16:779-801
Aim: We release the Janssen Toxicogenomics database. This rat liver gene-expression database was generated using Codelink microarrays, and has been used over the past years within Janssen to derive signatures for multiple end points and to classify p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::768fcd907ba92ea15c7881e0b295c2c9
https://doi.org/10.2217/pgs.15.38
https://doi.org/10.2217/pgs.15.38
Publikováno v:
Statistics in Biopharmaceutical Research. 4:185-193
This article presents a novel approach for developing a linear prediction rule to predict the non-genotoxic carcinogenicity potential of a new compound in the drug development pipeline. We construct the approach using data from 24-hour microarray exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbd4aa06fd309a5cf524ec32395ecfd4
https://doi.org/10.1198/sbr.2011.10049
https://doi.org/10.1198/sbr.2011.10049
Autor:
Paul, Nioi, Ingrid D R, Pardo, Philip J, Sherratt, Mark R, Fielden, Jeremy, Gollub, Alex, Nie, Ronald D, Snyder
Publikováno v:
Chemico-Biological Interactions. 176:252-260
Carcinogenicity of chemicals can currently only be evaluated in 2-year rodent bioassays. Therefore, the development of early biomarkers for carcinogenesis would result in substantial savings in time and expense. The current study investigates whether
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f671fe5f83f41b08e40cefd4152aa261
https://doi.org/10.1016/j.cbi.2008.09.005
https://doi.org/10.1016/j.cbi.2008.09.005
Autor:
Alex Nie, Anton Bittner, Michael K. McMillian, Andrew Carmen, Angelique Leone, Jackson S. Wan, J. Brandon Parker, Jay Nelson, Lynn Yieh, Peter Lord, Stewart Bryant
Publikováno v:
Molecular Carcinogenesis. 45:914-933
Toxicogenomics technology defines toxicity gene expression signatures for early predictions and hypotheses generation for mechanistic studies, which are important approaches for evaluating toxicity of drug candidate compounds. A large gene expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a17b7ad9b51fec94f63eb991ce5802ef
https://doi.org/10.1002/mc.20205
https://doi.org/10.1002/mc.20205
Publikováno v:
Basic Toxicology. 98:537-546
Understanding the response of biological systems to xenobiotics is fundamental to the evaluation of drug safety. Toxicologists have traditionally gathered pathological, morphological, chemical and biochemical information from in vivo studies of precl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b372e241b2680504b6e909ec875bef7
https://doi.org/10.1111/j.1742-7843.2006.pto_444.x
https://doi.org/10.1111/j.1742-7843.2006.pto_444.x
Autor:
Alex Nie, Xuejun Liu, J. Brandon Parker, Peter Lord, Mark D. Johnson, Anton Bittner, Angelique Leone, Michael Kemmerer, Lynn Yieh, Judy Herlich, Stewart Bryant, Michael K. McMillian, Jackson S. Wan
Publikováno v:
Toxicology and Applied Pharmacology. 207:171-178
Macrophage activators (MA), peroxisome proliferators (PP), and oxidative stressors/reactive metabolites (OS/RM) all produce oxidative stress and hepatotoxicity in rats. However, these three classes of hepatotoxicants give three distinct gene transcri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26251fef036b8d21bb65b1c86a06d8e9
https://doi.org/10.1016/j.taap.2005.02.031
https://doi.org/10.1016/j.taap.2005.02.031
Publikováno v:
Journal of Biopharmaceutical Statistics. 15:327-341
The intent of this article is to discuss some of the complexities of toxicogenomics data and the statistical design and analysis issues that arise in the course of conducting a toxicogenomics study. We also describe a procedure for classifying compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c639063409cca7f79f8d00bfa7a73143
https://doi.org/10.1081/bip-200048836
https://doi.org/10.1081/bip-200048836
Autor:
Anton Bittner, Jackson S. Wan, Xuejun Liu, J. Brandon Parker, Alex Nie, Mark D. Johnson, Angelique Leone, Lynn Yieh, Stewart Bryant, Michael Kemmerer, Yanhong Liu, Michael K. McMillian, Judy Herlich
Publikováno v:
Biochemical Pharmacology. 68:2249-2261
Formation of free radicals and other reactive molecules is responsible for the adverse effects produced by a number of hepatotoxic compounds. cDNA microarray technology was used to compare transcriptional profiles elicited by training and testing set
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27bcb5d7fd13bd04f8dbcec385b9018b
https://doi.org/10.1016/j.bcp.2004.08.003
https://doi.org/10.1016/j.bcp.2004.08.003
Autor:
Xuejun Liu, J. Brandon Parker, Alex Nie, Michael K. McMillian, Stewart Bryant, Anton Bittner, Jackson S. Wan, Mark D. Johnson, Lynn Yieh, Judy Herlich, Michael Kemmerer, Angelique Leone
Publikováno v:
Biochemical Pharmacology. 67:2141-2165
Macrophage activation contributes to adverse effects produced by a number of hepatotoxic compounds. Transcriptional profiles elicited by two macrophage activators, LPS and zymosan A, were compared to those produced by 100 paradigm compounds (mostly h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48755061947cb91bfb3da27997b78e35
https://doi.org/10.1016/j.bcp.2004.01.029
https://doi.org/10.1016/j.bcp.2004.01.029
Autor:
Angelique Leone, S. Jim Proctor, Geert R. Verheyen, Mark D. Johnson, Michael McMillian, L. Mark Kao, Leigh-Anne Piechta, Michael F. Kelley, Alex Nie, J. Brandon Parker, Peter G. Lord, Sharmilee Sawant
Publikováno v:
Toxicology and applied pharmacology. 275(3)
Previously we reported a gene expression signature in rat liver for detecting a specific type of oxidative stress (OS) related to reactive metabolites (RM). High doses of the drugs disulfiram, ethinyl estradiol and nimesulide were used with another d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69347aaaf400efa7d8b635ed062df927
https://pubmed.ncbi.nlm.nih.gov/24486436
https://pubmed.ncbi.nlm.nih.gov/24486436