Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Alex N Zelensky"'
Autor:
Maarten W Paul, Arshdeep Sidhu, Yongxin Liang, Sarah E van Rossum-Fikkert, Hanny Odijk, Alex N Zelensky, Roland Kanaar, Claire Wyman
Publikováno v:
eLife, Vol 10 (2021)
Breast cancer type two susceptibility protein (BRCA2) is an essential protein in genome maintenance, homologous recombination (HR), and replication fork protection. Its function includes multiple interaction partners and requires timely localization
Externí odkaz:
https://doaj.org/article/b6b37d495f8f43f28cdbe0c08ec1c3b6
Low dose ionizing radiation strongly stimulates insertional mutagenesis in a γH2AX dependent manner.
Autor:
Alex N Zelensky, Mascha Schoonakker, Inger Brandsma, Marcel Tijsterman, Dik C van Gent, Jeroen Essers, Roland Kanaar
Publikováno v:
PLoS Genetics, Vol 16, Iss 1, p e1008550 (2020)
Extrachromosomal DNA can integrate into the genome with no sequence specificity producing an insertional mutation. This process, which is referred to as random integration (RI), requires a double stranded break (DSB) in the genome. Inducing DSBs by v
Externí odkaz:
https://doaj.org/article/bf3eab025a804bc7947c4267ee639947
Autor:
Rania Ghouil, Simona Miron, Lieke Koornneef, Jasper Veerman, Maarten W. Paul, Marie-Hélène Le Du, Esther Sleddens-Linkels, Sari E. van Rossum-Fikkert, Yvette van Loon, Natalia Felipe-Medina, Alberto M. Pendas, Alex Maas, Jeroen Essers, Pierre Legrand, Willy M. Baarends, Roland Kanaar, Sophie Zinn-Justin, Alex N. Zelensky
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
BRCA2 and its interactor HSF2BP are required for meiotic recombination. Here, the authors define the interaction structurally, revealing that a repeat in BRCA2 binds two HSF2BP units, increasing the affinity. This region is, however, not essential fo
Externí odkaz:
https://doaj.org/article/0b53e0fe0b894a1fac23825f31a88406
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-7 (2017)
Random off-target integration events can impair precise gene targeting and poses a safety risk for gene therapy. Here the authors show that repression of polymerase θ and classical non-homologous recombination eliminates random integration.
Externí odkaz:
https://doaj.org/article/a9da6d7f29cb4983892c270e8629d44c
Autor:
Inger Brandsma, Koichi Sato, Sari E. van Rossum-Fikkert, Nicole van Vliet, Esther Sleddens, Marcel Reuter, Hanny Odijk, Nathalie van den Tempel, Dick H.W. Dekkers, Karel Bezstarosti, Jeroen A.A. Demmers, Alex Maas, Joyce Lebbink, Claire Wyman, Jeroen Essers, Dik C. van Gent, Willy M. Baarends, Puck Knipscheer, Roland Kanaar, Alex N. Zelensky
Publikováno v:
Cell Reports, Vol 27, Iss 13, Pp 3790-3798.e7 (2019)
Summary: The tumor suppressor BRCA2 is essential for homologous recombination (HR), replication fork stability, and DNA interstrand crosslink repair in vertebrates. We identify HSF2BP, a protein previously described as testis specific and not charact
Externí odkaz:
https://doaj.org/article/2637c90b510241f59a26f31c229eef63
Autor:
Rania Ghouil, Simona Miron, Koichi Sato, Dejan Ristic, Sari E. van Rossum-Fikkert, Pierre Legrand, Malika Ouldali, Jean-Marie Winter, Virginie Ropars, Gabriel David, Ana-Andreea Arteni, Claire Wyman, Puck Knipscheer, Roland Kanaar, Alex N. Zelensky, Sophie Zinn-Justin
In meiotic homologous recombination (HR), BRCA2 facilitates loading of the recombinases RAD51 and DMC1 at the sites of double-strand breaks. The HSF2BP-BRME1 complex interacts with BRCA2 to support its function in meiotic HR. In somatic cancer cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a63fac7b43e89c29cc08381458c700b7
https://doi.org/10.1101/2023.04.27.538421
https://doi.org/10.1101/2023.04.27.538421
Autor:
Puck Knipscheer, Nicole S. Verkaik, Anneke B. Oostra, Roland Kanaar, Koichi Sato, Josephine C. Dorsman, Alex N. Zelensky, Inger Brandsma, Sari E. van Rossum-Fikkert, Dik C. van Gent
Publikováno v:
Sato, K, Brandsma, I, van Rossum-Fikkert, S E, Verkaik, N, Oostra, A B, Dorsman, J C, van Gent, D C, Knipscheer, P, Kanaar, R & Zelensky, A N 2020, ' HSF2BP negatively regulates homologous recombination in DNA interstrand crosslink repair ', Nucleic Acids Research, vol. 48, no. 5, pp. 2442-2456 . https://doi.org/10.1093/nar/gkz1219
Nucleic Acids Research, 48(5), 2442-2456. Oxford University Press
Nucleic Acids Research, 48, 2442-2456. Oxford University Press
Nucleic Acids Research
Nucleic Acids Research, 48(5), 2442-2456. Oxford University Press
Nucleic Acids Research, 48, 2442-2456. Oxford University Press
Nucleic Acids Research
The tumor suppressor BRCA2 is essential for homologous recombination (HR), replication fork stability and DNA interstrand crosslink (ICL) repair in vertebrates. We show that ectopic production of HSF2BP, a BRCA2-interacting protein required for meiot
Autor:
Marie-Hélène Le Du, Maarten W. Paul, Roland Kanaar, Esther Sleddens-Linkels, Rania Ghouil, Alberto M. Pendás, Pierre Legrand, Lieke Koornneef, Yvette van Loon, Natalia Felipe-Medina, Jasper Veerman, Alex N. Zelensky, Jeroen Essers, Willy M. Baarends, Sari E. van Rossum-Fikkert, Sophie Zinn-Justin, Alex Maas, Simona Miron
Publikováno v:
Nature Communications
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications, 12(1):4605. Nature Publishing Group
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications, 12(1):4605. Nature Publishing Group
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
© The Author(s) 2021.
BRCA2 and its interactors are required for meiotic homologous recombination (HR) and fertility. Loss of HSF2BP, a BRCA2 interactor, disrupts HR during spermatogenesis. We test the model postulating that HSF2BP localizes BR
BRCA2 and its interactors are required for meiotic homologous recombination (HR) and fertility. Loss of HSF2BP, a BRCA2 interactor, disrupts HR during spermatogenesis. We test the model postulating that HSF2BP localizes BR
Autor:
Maarten W. Paul, Claire Wyman, Yongxin Liang, Roland Kanaar, Hanny Odijk, Sarah E van Rossum-Fikkert, Arshdeep Sidhu, Alex N. Zelensky
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28befe30d4df0f904f14a6d0bf2b6eb9
https://doi.org/10.7554/elife.67926.sa2
https://doi.org/10.7554/elife.67926.sa2
Autor:
Roland Kanaar, Claire Wyman, Hanny Odijk, Arshdeep Sidhu, Sarah E van Rossum-Fikkert, Yongxin Liang, Maarten W. Paul, Alex N. Zelensky
Publikováno v:
eLife
eLife, 10:e67926. eLife Sciences Publications
eLife, Vol 10 (2021)
eLife, 10:e67926. eLife Sciences Publications
eLife, Vol 10 (2021)
Breast cancer type two susceptibility protein (BRCA2) is an essential protein in genome maintenance, homologous recombination (HR), and replication fork protection. Its function includes multiple interaction partners and requires timely localization