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Improved therapies for high grade glioma (HGG) are imperative, as the median survival after diagnosis with grade IV glioma is 15 months. Recently pathways regulating neural development, such as the bone morphogenetic protein (BMP) pathway, have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6613dfab9512e140765b24b884f461be
https://europepmc.org/articles/PMC4217969/
https://europepmc.org/articles/PMC4217969/
Autor:
Bret C. Mobley, Michelle Stark, Ty W. Abel, Alex Munden, Zhiguo Zhao, Laura D. Hover, Sabah O. Ghazi
Publikováno v:
Journal of neuropathology and experimental neurology. 71(8)
Human high-grade gliomas (HGGs) are known for their histologic diversity. To address the role of cell of origin in glioma phenotype, transgenic mice were generated in which oncogenic Ras and p53 deletion were targeted to neural stem/progenitor cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ff851eff2a5907dbc24bcc4e67139de
https://pubmed.ncbi.nlm.nih.gov/22805776
https://pubmed.ncbi.nlm.nih.gov/22805776
Publikováno v:
Molecular BioSystems. 5:1004
Autocrine and paracrine signaling mechanisms are traditionally difficult to study due to the recursive nature of the process and the sub-micromolar concentrations involved. This has proven to be especially limiting in the study of embryonic stem cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90d80eb5a09fb7a2513d6447a0f30277
https://doi.org/10.1039/b905602e
https://doi.org/10.1039/b905602e