Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Alex Meuth"'
Autor:
Annayya Aroor, Marcin Zuberek, Cornel Duta, Alex Meuth, James R. Sowers, Adam Whaley-Connell, Ravi Nistala
Publikováno v:
International Journal of Molecular Sciences, Vol 17, Iss 5, p 780 (2016)
Proteinuria is a marker of incipient kidney injury in many disorders, including obesity. Previously, we demonstrated that megalin, a receptor endocytotic protein in the proximal tubule, is downregulated in obese mice, which was prevented by inhibitio
Externí odkaz:
https://doaj.org/article/33fd139c36194a67bd1de53bec2dae89
Autor:
Shawn Bender, Malathi Dona, Ian Hsu, Alex Meuth, Scott Brown, Chastidy Bailey, Christian Aragonez, Bysani Chandrasekar, Luis Martinez-Lemus, Vincent DeMarco, Laurel Grisanti, Iris Jaffe, Alex Pinto
Publikováno v:
Physiology. 38
Coronary microvascular dysfunction (CMD) is associated with cardiac dysfunction and predictive of cardiac mortality in obesity, especially in females. Emerging evidence suggests development of heart failure with preserved ejection fraction in females
Autor:
James R. Sowers, Jianzhong An, Alex Meuth, Annayya R. Aroor, Susan R McKarns, Cassandra Smith, Melvin R. Hayden, Javad Habibi, Shawn B. Bender, Ravi Nistala, Adam Whaley-Connell, Megan S. Johnson
Publikováno v:
Am J Physiol Renal Physiol
Recent evidence suggests that dipeptidyl peptidase-4 (DPP4) inhibition with saxagliptin (Saxa) is renoprotective under comorbid conditions associated with activation of the renin-angiotensin-aldosterone system (RAAS), such as diabetes, obesity, and h
Autor:
Shawn B. Bender, Bysani Chandrasekar, Douglas K. Bowles, Maloree Khan, Alex Meuth, Scott Brown
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 317:H357-H363
Elevated plasma aldosterone (Aldo) levels are associated with greater risk of cardiac ischemic events and cardiovascular mortality. Adenosine-mediated coronary vasodilation is a critical cardioprotective mechanism during ischemia; however, whether th
Coronary microvascular dysfunction predicts and may be a proximate cause of cardiac dysfunction and mortality in diabetes; however, few effective treatments exist for these conditions. We recently demonstrated that mineralocorticoid receptor (MR) ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::095de9e81a54ac675f3693290377767e
https://europepmc.org/articles/PMC6203694/
https://europepmc.org/articles/PMC6203694/
Publikováno v:
The FASEB Journal. 32
Publikováno v:
The FASEB Journal. 32
Publikováno v:
Hypertension. 70
Activation of the renin-angiotensin-aldosterone system (RAAS) drives blood pressure (BP) responses and kidney injury in humans and rodent models. Previously, we reported activation of dipeptidyl peptidase 4 (DPP4) by RAAS which may play an important
Autor:
Alex Meuth, Maloree Khan, Shawn B. Bender, James R. Sowers, Vincent G. DeMarco, Annayya R. Aroor, Cassandra Smith, Scott Brown, Gerald A. Meininger, Hannah M Cleeton, Bysani Chandrasekar, Ravi Nistala
Publikováno v:
Endocrinology. 158(10)
Activation of the renin-angiotensin-aldosterone system is common in hypertension and obesity and contributes to cardiac diastolic dysfunction, a condition for which no treatment currently exists. In light of recent reports that antihyperglycemia incr
Autor:
Thomas Klein, James R. Sowers, Javad Habibi, Ravi Nistala, Vincent G. DeMarco, Adam Whaley-Connell, Tamara S. Hancock, Melvin R. Hayden, Alex Meuth, William C Knight, Annayya R. Aroor
Publikováno v:
Obesity. 22:2172-2179
Objective Obesity-related glomerulopathy is characterized initially by glomerular hyperfiltration with hypertrophy and then development of proteinuria. Putative mechanisms include endothelial dysfunction and filtration barrier injury due to oxidant s