Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Alex McCampbell"'
Autor:
Mingdi Zhang, Yi Luo, Yi Chen, Curt Mazur, Giulio Srubek Tomassy, Linhong Sun, Alex McCampbell
Publikováno v:
Journal of visualized experiments : JoVE. (152)
The blood brain barrier (BBB) is an important defense against the entrance of potentially toxic or pathogenic agents from the blood into the central nervous system (CNS). However, its existence also dramatically lowers the accessibility of systemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ee4599a5ef1d1ab64c97ecd2977bf59
https://pubmed.ncbi.nlm.nih.gov/31736489
https://pubmed.ncbi.nlm.nih.gov/31736489
Autor:
Mariah L. Hoye, Holly B. Kordasiewicz, Jessica Amacker, Sai Thankamony, Amy Setnicka, Alex McCampbell, Amy J. Wegener, Mingdi Zhang, Linhong Sun, David W. Salzman, Brandon J. Farley, Merit Cudkowicz, C. Frank Bennett, Mark Shabsovich, Danielle Graham, Giulio Srubek Tomassy, Nicole Comfort, Timothy M. Miller, Bin Wang, Kathleen M. Schoch, Yi Luo, Eric E. Swayze, Tracy Cole
Publikováno v:
The Journal of clinical investigation. 128(8)
Mutations in superoxide dismutase 1 (SOD1) are responsible for 20% of familial ALS. Given the gain of toxic function in this dominantly inherited disease, lowering SOD1 mRNA and protein is predicted to provide therapeutic benefit. An early generation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1c9a9db19cebf9cb5709dffbfab35ba
https://pubmed.ncbi.nlm.nih.gov/30010620
https://pubmed.ncbi.nlm.nih.gov/30010620
Autor:
Luca Benetti, Raul Lacson, Joseph F. Heyse, Shane D. Marine, Erica Stec, Xiaohua Douglas Zhang, Joel P. Berger, Keith A. Soper, Daniel J. Holder, Dawn Toolan, Marc Ferrer, Ruojing Yang, Qian Wu, Alex McCampbell, Francesca Santini
Publikováno v:
Bioinformatics. 27:2775-2781
Motivation: Off-target activity commonly exists in RNA interference (RNAi) screens and often generates false positives. Existing analytic methods for addressing the off-target effects are demonstrably inadequate in RNAi confirmatory screens. Results:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79a90f4cb27c8d63fd704a9631254820
https://doi.org/10.1093/bioinformatics/btr474
https://doi.org/10.1093/bioinformatics/btr474
Autor:
Marc Ferrer, Joel P. Berger, Joseph F. Heyse, Alex McCampbell, Daniel J. Holder, Shane Marine, Timothy R. Hare, Dawn Toolan, Ruojing Yang, Joleen Kajdas, Xiaohua Douglas Zhang, Raul Lacson
Publikováno v:
SLAS Discovery. 15:1123-1131
In genome-scale RNA interference (RNAi) screens, it is critical to control false positives and false negatives statistically. Traditional statistical methods for controlling false discovery and false nondiscovery rates are inappropriate for hit selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b2647342705c4e38b0f67567228b167
https://doi.org/10.1177/1087057110381919
https://doi.org/10.1177/1087057110381919
Autor:
Robert H. Brown, Anke Penno, Thorsten Hornemann, Florian Eichler, Lohit Kini, Ho-Joon Lee, Ken Gable, Guiman Guan, Kevin Garofalo, Arnold von Eckardstein, Clifford J. Woolf, Martin K. Selig, Matthew P. Frosch, Alex Mccampbell, Eric Tamrazian, Daniel Vardeh, Jeffrey M. Harmon, Teresa M. Dunn, Dika Kuljis
Publikováno v:
The Journal of Neuroscience. 29:14646-14651
Mutations in the SPTLC1 subunit of serine palmitoyltransferase (SPT) cause an adult-onset, hereditary sensory, and autonomic neuropathy type I (HSAN1). We previously reported that mice bearing a transgene-expressing mutant SPTLC1 (tgSPTLC1C133W) show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c5cb3616befcb2b119c650c6a7df6ea
https://doi.org/10.1523/jneurosci.2536-09.2009
https://doi.org/10.1523/jneurosci.2536-09.2009