Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Alex Martin-Trujillo"'
Autor:
Alex Martin-Trujillo, Enrique Vidal, Ana Monteagudo-Sánchez, Marta Sanchez-Delgado, Sebastian Moran, Jose Ramon Hernandez Mora, Holger Heyn, Miriam Guitart, Manel Esteller, David Monk
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Altered genomic imprinting is frequently reported in cancer. Here, the authors analyze copy number and methylation in cancer cell lines and primary tumors to show that imprinted methylation profiles represent the accumulation of copy number alteratio
Externí odkaz:
https://doaj.org/article/0ced9395b01e4ea4b12aeea8da2c0e0e
Autor:
Marta Sanchez-Delgado, Franck Court, Enrique Vidal, Jose Medrano, Ana Monteagudo-Sánchez, Alex Martin-Trujillo, Chiharu Tayama, Isabel Iglesias-Platas, Ivanela Kondova, Ronald Bontrop, Maria Eugenia Poo-Llanillo, Tomas Marques-Bonet, Kazuhiko Nakabayashi, Carlos Simón, David Monk
Publikováno v:
PLoS Genetics, Vol 12, Iss 11, p e1006427 (2016)
Thousands of regions in gametes have opposing methylation profiles that are largely resolved during the post-fertilization epigenetic reprogramming. However some specific sequences associated with imprinted loci survive this demethylation process. He
Externí odkaz:
https://doaj.org/article/0e4b89b8a6004bec95c52f9a1c7cafd9
Autor:
Isabel Iglesias-Platas, Alex Martin-Trujillo, Davide Cirillo, Franck Court, Amy Guillaumet-Adkins, Cristina Camprubi, Deborah Bourc'his, Kenichiro Hata, Robert Feil, Gian Tartaglia, Philippe Arnaud, David Monk
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38907 (2012)
Genomic imprinting is a complex epigenetic mechanism of transcriptional control that utilizes DNA methylation and histone modifications to bring about parent-of-origin specific monoallelic expression in mammals. Genes subject to imprinting are often
Externí odkaz:
https://doaj.org/article/75a973f630334971b059ce2ecb05af1d
Autor:
Ana Monteagudo-Sánchez, Enrique Vidal, Alex Martin-Trujillo, David Monk, Sebastian Moran, Marta Sanchez-Delgado, Holger Heyn, Manel Esteller, Miriam Guitart, Jose Ramon Hernandez Mora
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Nature Communications
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Nature Communications
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona
It has been postulated that imprinting aberrations are common in tumors. To understand the role of imprinting in cancer, we have characterized copy-number and methylation in over 280 cancer cell lines and confirm our observations in primary tumors. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4422d64b46c686f59e8fcb96dbe538c
https://doaj.org/article/0ced9395b01e4ea4b12aeea8da2c0e0e
https://doaj.org/article/0ced9395b01e4ea4b12aeea8da2c0e0e
Autor:
Adrian J. Thrasher, Michelangelo Campanella, Kate E. Hawkins, James Adjaye, Anna Maria Ranzoni, Pascale V. Guillot, Paolo De Coppi, Dafni Moschidou, Kwan-Leong Hau, Wasco Wruck, Alex Martin-Trujillo, Fabio Tommasini, Simon Eaton, David Monk, Veronica Sanchez-Freire, Danilo Faccenda
Publikováno v:
Molecular Therapy
Dipòsit Digital de la UB
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname
Europe PubMed Central
Dipòsit Digital de la UB
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname
Europe PubMed Central
Restoring pluripotency using chemical compounds alone would be a major step forward in developing clinical-grade pluripotent stem cells, but this has not yet been reported in human cells. We previously demonstrated that VPA_ AFS cells, human amniocyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a0f357034d4e2bb2aa916a538d2055b
http://hdl.handle.net/2445/124487
http://hdl.handle.net/2445/124487
Autor:
Alex Martin-Trujillo, Paolo Petazzi, David Monk, Manel Esteller, Isabel Iglesias-Platas, Amy Guillaumet-Adkins
Publikováno v:
Human Molecular Genetics. 23:6275-6285
Genomic imprinting is the epigenetic process that results in monoallelic expression of genes depending on parental origin. These genes are known to be critical for placental development and fetal growth in mammals. Aberrant epigenetic profiles at imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e190d27c2a20d505a2bdfd449cc33a9c
https://doi.org/10.1093/hmg/ddu347
https://doi.org/10.1093/hmg/ddu347
Autor:
Naoko Sugahara, Isabel Iglesias-Platas, David Monk, Carlos Simón, Alex Martin-Trujillo, Chiharu Tayama, Tsutomu Ogata, Julie V. Harness, Franck Court, Jose V. Sanchez-Mut, Manel Esteller, Kazuhiko Nakabayashi, Valeria Romanelli, Kohji Okamura, Hidenobu Soejima, Norio Wake, Kenichiro Hata, Pablo Lapunzina, Eisuke Kaneki, Harry Moore, Hans S. Keirstead
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Universidad de Barcelona
Genomic imprinting is a form of epigenetic regulation that results in the expression of either the maternally or paternally inherited allele of a subset of genes (Ramowitz and Bartolomei 2011). This imprinted expression of transcripts is crucial for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e46d2d78df5c9fd3aa26e4bb554eea4f
https://doi.org/10.1101/gr.164913.113
https://doi.org/10.1101/gr.164913.113
Autor:
David Monk, Marta Sanchez-Delgado, Alex Martin-Trujillo, Maria Eugenia Poo-Llanillo, Kazuhiko Nakabayashi, Tomas Marques-Bonet, Chiharu Tayama, Jose V. Medrano, Ronald E. Bontrop, Franck Court, Carlos Simón, Isabel Iglesias-Platas, Ana Monteagudo-Sánchez, Enrique Vidal, Ivanela Kondova
Publikováno v:
PLoS Genetics, Vol 12, Iss 11, p e1006427 (2016)
PLOS GENETICS
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
Recercat. Dipósit de la Recerca de Catalunya
PLoS Genetics
Dipòsit Digital de la UB
Universidad de Barcelona
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Digital.CSIC. Repositorio Institucional del CSIC
PLoS Genetics, 12(11). Public Library of Science
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
PLOS GENETICS
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
Recercat. Dipósit de la Recerca de Catalunya
PLoS Genetics
Dipòsit Digital de la UB
Universidad de Barcelona
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Digital.CSIC. Repositorio Institucional del CSIC
PLoS Genetics, 12(11). Public Library of Science
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
Thousands of regions in gametes have opposing methylation profiles that are largely resolved during the post-fertilization epigenetic reprogramming. However some specific sequences associated with imprinted loci survive this demethylation process. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8511361c8aea07fd80420283a057d2d5
http://europepmc.org/articles/PMC5106035?pdf=render
http://europepmc.org/articles/PMC5106035?pdf=render
Autor:
Manel Esteller, Julián Nevado, Mabel Segovia, Elena Vallespín, Victor Martinez-Glez, Sixto García-Miñaur, Irene Dapía, Gema Gordo, Pablo Lapunzina, Alex Martin-Trujillo, Claudia Perandones, Pedro Arias, María Palomares, Rocío Mena, Luis A. Pérez Jurado, Valeria Romanelli, Jair Tenorio, García-Moya Fernández, David Monk, Guiomar Perez de Nanclares, Fernando Santos-Simarro, Mario F. Fraga
Publikováno v:
American journal of medical genetics. Part A. 170(10)
Beckwith-Wiedemann syndrome (BWS) is an overgrowth syndrome characterized by an excessive prenatal and postnatal growth, macrosomia, macroglossia, and hemihyperplasia. The molecular basis of this syndrome is complex and heterogeneous, involving genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e97e8146792f8ff64ae4a1c8f5a3809
https://pubmed.ncbi.nlm.nih.gov/27480579
https://pubmed.ncbi.nlm.nih.gov/27480579
Autor:
David Monk, Cristina Camprubí, Chiharu Tayama, Hidenobu Soejima, Hiroyuki Aburatani, Alex Martin Trujillo, Pablo Lapunzina, Kenichiro Hata, Genta Nagae, Kazuhiko Nakabayashi, Tsutomu Ogata, Wataru Yoshida, Aurora Sánchez
Publikováno v:
Human Molecular Genetics. 20:3188-3197
Nuclear transfer experiments undertaken in the mid-80's revealed that both maternal and paternal genomes are necessary for normal development. This is due to genomic imprinting, an epigenetic mechanism that results in parent-of-origin monoallelic exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9cbe7ac1d6a9024fba87412bcd2dc68
https://doi.org/10.1093/hmg/ddr224
https://doi.org/10.1093/hmg/ddr224