Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Alex Marki"'
Autor:
Gregory J. Golden, Alejandro Gómez Toledo, Alex Marki, James T. Sorrentino, Claire Morris, Raquel J. Riley, Charlotte Spliid, Qiongyu Chen, Ingrid Cornax, Nathan E. Lewis, Nissi Varki, Dzung Le, Johan Malmström, Christofer Karlsson, Klaus Ley, Victor Nizet, Jeffrey D. Esko
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
Vascular glycocalyx remodeling is critical to sepsis pathology, but the glycocalyx components that contribute to this process remain poorly characterized. This article shows that during Staphylococcus aureus
Externí odkaz:
https://doaj.org/article/587771f197f24abdb65b991885346424
Autor:
Dennis Wolf, Nathaly Anto-Michel, Hermann Blankenbach, Ansgar Wiedemann, Konrad Buscher, Jan David Hohmann, Bock Lim, Marina Bäuml, Alex Marki, Maximilian Mauler, Daniel Duerschmied, Zhichao Fan, Holger Winkels, Daniel Sidler, Philipp Diehl, Dirk M Zajonc, Ingo Hilgendorf, Peter Stachon, Timoteo Marchini, Florian Willecke, Maximilian Schell, Björn Sommer, Constantin von zur Muhlen, Jochen Reinöhl, Teresa Gerhardt, Edward F. Plow, Valentin Yakubenko, Peter Libby, Christoph Bode, Klaus Ley, Karlheinz Peter, Andreas Zirlik
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Integrin-based therapeutics could block inflammatory processes but they also impair host defence, limiting their usefulness. Here the authors report an anti-Mac1 antibody that blocks its interaction with pro-inflammatory ligand CD40L but not other li
Externí odkaz:
https://doaj.org/article/ae4c48a947914a8f8492c31615ba0c38
Autor:
Michael Abadier, Akula Bala Pramod, Sara McArdle, Alex Marki, Zhichao Fan, Edgar Gutierrez, Alex Groisman, Klaus Ley
Publikováno v:
Cell Reports, Vol 21, Iss 13, Pp 3885-3899 (2017)
The adaptive immune response involves T cell differentiation and migration to sites of inflammation. T cell trafficking is initiated by rolling on inflamed endothelium. Tethers and slings, discovered in neutrophils, facilitate cell rolling at high sh
Externí odkaz:
https://doaj.org/article/2cf9a5879a9f4aa698706144be6e373f
Publikováno v:
Life, Vol 11, Iss 6, p 515 (2021)
Leukocytes, including neutrophils, propelled by blood flow, can roll on inflamed endothelium using transient bonds between selectins and their ligands, and integrins and their ligands. When such receptor–ligand bonds last long enough, the leukocyte
Externí odkaz:
https://doaj.org/article/dcb94c6b342e4a1799df98afc1ca00a3
Autor:
Zhichao Fan, Sara McArdle, Alex Marki, Zbigniew Mikulski, Edgar Gutierrez, Britta Engelhardt, Urban Deutsch, Mark Ginsberg, Alex Groisman, Klaus Ley
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Integrin β2 attachment regulates inflammation via effects on neutrophil rolling and extravasation through sequential integrin extension then headpiece opening. Here the authors show an alternative open headpiece prior to extension stabilized in cisb
Externí odkaz:
https://doaj.org/article/bf21e777e3c842518d89e822f46d2e45
Autor:
Alex Marki, Klaus Ley
Publikováno v:
Immunol Rev
Neutrophils are immune cells involved in several inflammatory and homeostatic processes. Their capacity to release cargo can be classified based on whether the cargo is released on its own, or in conjunction with plasma membrane structures. Examples
Autor:
Lai Wen, Alex Marki, Zhihao Wang, Marco Orecchioni, Jeffrey Makings, Kenneth Kim, William B. Kiosses, Zbigniew Mikulski, Klaus Ley
Publikováno v:
The FASEB Journal. 36
Autor:
Ningguo Feng, Yuhan Bi, Eugene C. Butcher, Martin Brennan, Klaus Ley, Clare L. Abram, Lars Nitschke, Harry B. Greenberg, Borja Ocón, Alex Marki, Carolin Brandl, Clifford A. Lowell, Matthew S. Macauley, Romain Ballet, Takeshi Tsubata, Julian Cheng, Amin Alborzian Deh Sheikh, Jeremy Berri
Publikováno v:
Nature Immunology. 22:381-390
The integrin α4β7 selectively regulates lymphocyte trafficking and adhesion in the gut and gut-associated lymphoid tissue (GALT). Here, we describe unexpected involvement of the tyrosine phosphatase Shp1 and the B cell lectin CD22 (Siglec-2) in the
Bone marrow transplantation rescues monocyte recruitment defect and improves cystic fibrosis in mice
Autor:
Zhichao Fan, Elise Pitmon, Lai Wen, Jacqueline Miller, Erik Ehinger, Rana Herro, Wei Liu, Ju Chen, Zbigniew Mikulski, Douglas J. Conrad, Alex Marki, Marco Orecchioni, Puja Kumari, Yanfang Peipei Zhu, Paola M. Marcovecchio, Catherine C. Hedrick, Craig A. Hodges, Vijay A. Rathinam, Kepeng Wang, Klaus Ley
Publikováno v:
J Immunol
Cystic fibrosis (CF) is an inherited life-threatening disease accompanied by repeated lung infections and multiorgan inflammation that affects tens of thousands of people worldwide. The causative gene, cystic fibrosis transmembrane conductance regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b15d59291a6da7a1c257600eac92868
https://europepmc.org/articles/PMC8855460/
https://europepmc.org/articles/PMC8855460/
Autor:
Qiongyu Chen, Nathan E. Lewis, Charlotte B. Spliid, Jeffrey D. Esko, Nissi Varki, Alex Marki, Raquel J Riley, Dzung T. Le, Alejandro Gomez Toledo, Gregory J. Golden, Christofer Karlsson, James T. Sorrentino, Klaus Ley, Johan Malmström, Victor Nizet, Claire Morris, Ingrid Cornax
Publikováno v:
mBio, vol 12, iss 5
mBio, Vol 12, Iss 5 (2021)
mBio
mBio, Vol 12, Iss 5 (2021)
mBio
Hepatic failure is an important risk factor for poor outcome in septic patients. Using a chemical tagging workflow and high-resolution mass spectrometry, we demonstrate that rapid proteome remodeling of the vascular surfaces precedes hepatic damage i