Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Alex Mann"'
Publikováno v:
SAGE Open Medicine, Vol 8 (2020)
Objectives: Symptoms of sore throat result from oropharyngeal inflammation, for which prostaglandin E 2 is a key mediator. Flurbiprofen is a non-steroidal anti-inflammatory that provides sore throat relief. The preliminary objective of this study was
Externí odkaz:
https://doaj.org/article/6041807d2e3842649d32c3b8c432f682
Autor:
Andrew P. Catchpole, Daniel J. Fullen, Nicolas Noulin, Alex Mann, Anthony S. Gilbert, Rob Lambkin-Williams
Publikováno v:
BMC Research Notes, Vol 11, Iss 1, Pp 1-6 (2018)
Abstract Objective This manuscript aims to provide an overview of the unique considerations and best practice principles associated with the manufacture of human viral challenge agents. Results Considerations are discussed on the entire process from
Externí odkaz:
https://doaj.org/article/9c82bfaafacd44eb9a4d8141e98e8d7f
Publikováno v:
Respiratory Research, Vol 19, Iss 1, Pp 1-15 (2018)
Abstract The Human Viral Challenge (HVC) model has, for many decades, helped in the understanding of respiratory viruses and their role in disease pathogenesis. In a controlled setting using small numbers of volunteers removed from community exposure
Externí odkaz:
https://doaj.org/article/c5865e474eea460198a247083356f043
Autor:
Daniel J Fullen, Nicolas Noulin, Andrew Catchpole, Hosnieh Fathi, Edward J Murray, Alex Mann, Kingsley Eze, Ganesh Balaratnam, Daryl W Borley, Anthony Gilbert, Rob Lambkin-Williams
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157211 (2016)
[This corrects the article DOI: 10.1371/journal.pone.0145902.].
Externí odkaz:
https://doaj.org/article/f3557ce9de1b494b9924c08d2166801a
Autor:
Daniel J Fullen, Bryan Murray, Julie Mori, Andrew Catchpole, Daryl W Borley, Edward J Murray, Ganesh Balaratnam, Anthony Gilbert, Alex Mann, Fiona Hughes, Rob Lambkin-Williams
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0166113 (2016)
Human Rhinovirus infection is an important precursor to asthma and chronic obstructive pulmonary disease exacerbations and the Human Viral Challenge model may provide a powerful tool in studying these and other chronic respiratory diseases. In this s
Externí odkaz:
https://doaj.org/article/3c0d13c65ac4419687d01e8a1a6f92e7
Autor:
Rob Lambkin-Williams, Colin Gelder, Richard Broughton, Corey P Mallett, Anthony S Gilbert, Alex Mann, David He, John S Oxford, David Burt
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0163089 (2016)
A Proteosome-adjuvanted trivalent inactivated influenza vaccine (P-TIV) administered intra-nasally was shown to be safe, well tolerated and immunogenic in both systemic and mucosal compartments, and effective at preventing illness associated with evi
Externí odkaz:
https://doaj.org/article/2f97a21b47f74354907b28ad87dd25ce
Autor:
Daniel J Fullen, Nicolas Noulin, Andrew Catchpole, Hosnieh Fathi, Edward J Murray, Alex Mann, Kingsley Eze, Ganesh Balaratnam, Daryl W Borley, Anthony Gilbert, Rob Lambkin-Williams
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0145902 (2016)
BACKGROUND:Influenza and its associated diseases are a major cause of morbidity and mortality. The United States Advisory Committee on Immunization Practices recommends influenza vaccination for everyone over 6 months of age. The failure of the flu v
Externí odkaz:
https://doaj.org/article/c8c4e973c1824f749324bb715d0ecd01
Autor:
Rik G.H. Lindeboom, Kaylee B. Worlock, Lisa M. Dratva, Masahiro Yoshida, David Scobie, Helen R. Wagstaffe, Laura Richardson, Anna Wilbrey-Clark, Josephine L. Barnes, Krzysztof Polanski, Jessica Allen-Hyttinen, Puja Mehta, Dinithi Sumanaweera, Jacqueline Boccacino, Waradon Sungnak, Ni Huang, Lira Mamanova, Rakesh Kapuge, Liam Bolt, Elena Prigmore, Ben Killingley, Mariya Kalinova, Maria Mayer, Alison Boyers, Alex Mann, Vitor Teixeira, Sam M. Janes, Rachel C. Chambers, Muzlifah Haniffa, Andrew Catchpole, Robert Heyderman, Mahdad Noursadeghi, Benny Chain, Andreas Mayer, Kerstin B. Meyer, Christopher Chiu, Marko Z. Nikolić, Sarah A. Teichmann
The COVID-19 pandemic is an ongoing global health threat, yet our understanding of the cellular disease dynamics remains limited. In our unique COVID-19 human challenge study we used single cell genomics of nasopharyngeal swabs and blood to temporall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d220950228bcc70a9b7e6d3734f32b9f
https://doi.org/10.1101/2023.04.13.23288227
https://doi.org/10.1101/2023.04.13.23288227
Autor:
Jie Zhou, Anika Singanayagam, Niluka Goonawardane, Maya Moshe, Fiachra Sweeney, Ksenia Sukhova, Ben Killingley, Mariya Kalinova, Alex Mann, Andrew Catchpole, Michael R. Barer, Neil M. Ferguson, Chris Chiu, Wendy S. Barclay
Background: Effectively implementing strategies to curb SARS-CoV-2 transmission requires understanding who is contagious and when. Whilst viral load (VL) on upper respiratory swabs has commonly been used to infer contagiousness, measuring viral emiss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c4a7aecc878b01b34ce63a447394aaf
http://hdl.handle.net/10044/1/103543
http://hdl.handle.net/10044/1/103543
Autor:
Beate Schmoele-Thoma, Agnieszka M. Zareba, Qin Jiang, Mohan S. Maddur, Rana Danaf, Alex Mann, Kingsley Eze, Juin Fok-Seang, Golam Kabir, Andrew Catchpole, Daniel A. Scott, Alejandra C. Gurtman, Kathrin U. Jansen, William C. Gruber, Philip R. Dormitzer, Kena A. Swanson
Publikováno v:
The New England journal of medicine. 386(25)
Although human respiratory syncytial virus (RSV) is an important cause of illness and death in older adults, no RSV vaccine has been licensed.In a phase 2a study, we randomly assigned healthy adults (18 to 50 years of age), in a 1:1 ratio, to receive