Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Alex M. Sykes"'
Publikováno v:
Exploration of Medicine, Vol 4, Iss 5, Pp 695-708 (2023)
Aim: Parkinson’s disease (PD) is a complex, chronic neurodegenerative disorder with predominately sporadic etiology. Intricate genetic-environmental interactions lead to the hallmarks of the disease: degeneration of dopaminergic neurons and the dep
Externí odkaz:
https://doaj.org/article/8e18e86db3e34e0e83f3ac44691853c3
Autor:
Manuela Völkner, Felix Wagner, Thomas Kurth, Alex M. Sykes, Claudia Del Toro Runzer, Lynn J. A. Ebner, Cagri Kavak, Vasileia Ismini Alexaki, Peter Cimalla, Mirko Mehner, Edmund Koch, Mike O. Karl
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Neurodegenerative diseases remain incompletely understood and therapies are needed. Stem cell-derived organoid models facilitate fundamental and translational medicine research. However, to which extent differential neuronal and glial pathologic proc
Externí odkaz:
https://doaj.org/article/b6df85ddea224a268d9f688df0becab5
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2023)
Parkinson’s disease (PD) is a chronic neurodegenerative disease that is characterized by a loss of dopaminergic neurons in the substantia nigra pars compacta of the midbrain (SNpc). Extensive studies into genetic and cellular models of PD implicate
Externí odkaz:
https://doaj.org/article/9466d8dad023442083f13a20d31c0d0d
Autor:
Steven R. Bentley, Suliman Khan, Marco Öchsner, Susitha Premarathne, Zain Aslam, Javed Y. Fowdar, Jamila Iqbal, Muhammad Naeem, Christopher A. Love, Stephen A. Wood, George D. Mellick, Alex M. Sykes
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
The study of consanguineous families has provided novel insights into genetic causes of monogenic parkinsonism. Here, we present a family from the rural Khyber Pakhtunkhwa province, Pakistan, where three siblings were diagnosed with early-onset parki
Externí odkaz:
https://doaj.org/article/5a51418bc4344b788a604a11a65095cc
Autor:
Tara L. Walker, Rupert W. Overall, Steffen Vogler, Alex M. Sykes, Susann Ruhwald, Daniela Lasse, Muhammad Ichwan, Klaus Fabel, Gerd Kempermann
Publikováno v:
Stem Cell Reports, Vol 6, Iss 4, Pp 552-565 (2016)
Here, we show that the lysophosphatidic acid receptor 1 (LPA1) is expressed by a defined population of type 1 stem cells and type 2a precursor cells in the adult mouse dentate gyrus. LPA1, in contrast to Nestin, also marks the quiescent stem cell pop
Externí odkaz:
https://doaj.org/article/1dc3fe225b8141c287efb868d5ac4192
Autor:
Stephen A. Wood, Peter G. Hains, Arnaud Muller, Melissa Hill, Susitha Premarathne, Mariyam Murtaza, Phillip J. Robinson, George D. Mellick, Alex M. Sykes
Publikováno v:
PROTEOMICS – Clinical Applications. 16:2200015
Parkinson's disease (PD) is the second most prevalent neurodegenerative disease. It is generally diagnosed clinically after the irreversible loss of dopaminergic neurons and no general biomarkers currently exist. To gain insight into the underlying c
Autor:
Holly E. Sherman, Stephen A. Wood, Alex M. Sykes, Peter A. Silburn, Steven R. Bentley, Ilaria Guella, Hannah M. Neuendorf, Javed Fowdar, Matthew J. Farrer, George D. Mellick
Publikováno v:
Genes, Vol 12, Iss 430, p 430 (2021)
Genes
Volume 12
Issue 3
Genes
Volume 12
Issue 3
Parkinson’s disease (PD) is typically sporadic
however, multi-incident families provide a powerful platform to discover novel genetic forms of disease. Their identification supports deciphering molecular processes leading to disease and may in
however, multi-incident families provide a powerful platform to discover novel genetic forms of disease. Their identification supports deciphering molecular processes leading to disease and may in
Autor:
Melissa A. Hill, Steven R. Bentley, Tara L. Walker, George D. Mellick, Stephen A. Wood, Alex M. Sykes
Publikováno v:
PloS one. 17(7)
The genetic study of multi-incident families is a powerful tool to investigate genetic contributions to the development of Parkinson’s disease. In this study, we identified the rare PTPRA p.R223W variant as one of three putative genetic factors pot
Autor:
Jutta Ludwig-Müller, Tara L. Walker, Zeina Nicola, Merve Bulut, Gerd Kempermann, Alex M. Sykes, Leonardo Ortiz-López, Rupert W. Overall, Muhammad Ichwan, Vijay S. Adusumilli, Gerardo Ramírez-Rodríguez, Christoph Böttcher, Norbert Hubner, Enrique A. Lugo-Hernández
Publikováno v:
Stem cell reports 16(3), 548-565 (2021). doi:10.1016/j.stemcr.2021.01.005
Stem Cell Reports
Stem Cell Reports
Summary As mammals evolved with exposure to particular diets, naturally abundant compounds may have become part of the set of environmental co-determinants that shaped brain structure and function. Here we investigated whether bioactive factors found
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e15b0ea64c8d6286e334014b640ae6b
https://pub.dzne.de/record/157719
https://pub.dzne.de/record/157719
Autor:
Joanna M. Wasielewska, Gerd Kempermann, Alex M. Sykes, Lisa Grönnert, Tara L. Walker, Ruslan Rust, Axel Roers, Nicole Rund, Lukas Donix, Anja Hoppe
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-1 (2020)
Scientific reports 10(1), 19816 (2020). doi:10.1038/s41598-020-76589-y
Scientific Reports, Vol 10, Iss 1, Pp 1-1 (2020)
Scientific reports 10(1), 19816 (2020). doi:10.1038/s41598-020-76589-y
There is growing evidence that both peripheral and resident immune cells play an important part in regulating adult neural stem cell proliferation and neurogenesis, although the contribution of the various immune cell types is still unclear. Mast cel