Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Alex M. Mawla"'
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-22 (2023)
Abstract Background High throughput sequencing has enabled the interrogation of the transcriptomic landscape of glucagon-secreting alpha cells, insulin-secreting beta cells, and somatostatin-secreting delta cells. These approaches have furthered our
Externí odkaz:
https://doaj.org/article/88fba080321243b2a665f04216b48639
Autor:
Jeeyeon Cha, Xin Tong, Emily M. Walker, Tehila Dahan, Veronica A. Cochrane, Sudipta Ashe, Ronan Russell, Anna B. Osipovich, Alex M. Mawla, Min Guo, Jin-hua Liu, Zachary A. Loyd, Mark O. Huising, Mark A. Magnuson, Matthias Hebrok, Yuval Dor, Roland Stein
Publikováno v:
JCI Insight, Vol 8, Iss 16 (2023)
Type 2 diabetes (T2D) is associated with compromised identity of insulin-producing pancreatic islet β cells, characterized by inappropriate production of other islet cell–enriched hormones. Here, we examined how hormone misexpression was influence
Externí odkaz:
https://doaj.org/article/d8557c8689a94c42a21473f2861b2627
Autor:
Michael R. DiGruccio, Alex M. Mawla, Cynthia J. Donaldson, Glyn M. Noguchi, Joan Vaughan, Christopher Cowing-Zitron, Talitha van der Meulen, Mark O. Huising
Publikováno v:
Molecular Metabolism, Vol 5, Iss 7, Pp 449-458 (2016)
Objective: Complex local crosstalk amongst endocrine cells within the islet ensures tight coordination of their endocrine output. This is illustrated by the recent demonstration that the negative feedback control by delta cells within pancreatic isle
Externí odkaz:
https://doaj.org/article/72b50362585d4cf5b98c0bc6664dd014
Autor:
Alfonso Rubio-Navarro, Nicolás Gómez-Banoy, Lisa Stoll, Friederike Dündar, Alex M. Mawla, Lunkun Ma, Eric Cortada, Paul Zumbo, Ang Li, Moritz Reiterer, Nathalia Montoya-Oviedo, Edwin A. Homan, Norihiro Imai, Ankit Gilani, Chengyang Liu, Ali Naji, Boris Yang, Angie Chi Nok Chong, David E. Cohen, Shuibing Chen, Jingli Cao, Geoffrey S. Pitt, Mark O. Huising, Doron Betel, James C. Lo
Publikováno v:
Nature Cell Biology. 25:565-578
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7138aa6c2bd2f5ff308610d3f18fb3de
https://doi.org/10.1038/s41556-023-01103-1
https://doi.org/10.1038/s41556-023-01103-1
Autor:
Montgomery Blencowe, Tatyana Gurlo, Fuying Gao, Peter C. Butler, Mark O. Huising, Alex M. Mawla, Lina Pei, Madeline Rosenberger, Giovanni Coppola, Hiroshi Nomoto, Xia Yang, Q. Wang, Allison Furterer
Publikováno v:
Diabetologia
Diabetologia, vol 65, iss 1
Diabetologia, vol 65, iss 1
Aims/hypothesis Type 2 diabetes is characterised by islet amyloid and toxic oligomers of islet amyloid polypeptide (IAPP). We posed the questions, (1) does IAPP toxicity induce an islet response comparable to that in humans with type 2 diabetes, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6701a0429c66bb8f4a4fe29216a80109
http://europepmc.org/articles/PMC8660728
http://europepmc.org/articles/PMC8660728
Autor:
Sooyeon Lee, Haixia Xu, Aidan Van Vleck, Alex M. Mawla, Albert Mao Li, Jiangbin Ye, Mark O. Huising, Justin P. Annes
Publikováno v:
Diabetes, vol 71, iss 7
Mitochondrial dysfunction plays a central role in type 2 diabetes (T2D); however, the pathogenic mechanisms in pancreatic β-cells are incompletely elucidated. Succinate dehydrogenase (SDH) is a key mitochondrial enzyme with dual functions in the tri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3866d305ef38e1211175c6227a560be9
https://doi.org/10.2337/figshare.19566037.v1
https://doi.org/10.2337/figshare.19566037.v1
Publikováno v:
BMC genomics, vol 24, iss 1
Background High throughput sequencing has enabled the interrogation of the transcriptomic landscape of glucagon-secreting alpha cells, insulin-secreting beta cells, and somatostatin-secreting delta cells. These approaches have furthered our understan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb5e1449e57b570167fd287b88f33156
https://doi.org/10.1101/2021.12.06.471006
https://doi.org/10.1101/2021.12.06.471006
Autor:
Mark O. Huising, Alex M. Mawla
SummaryepiRomics is an R package designed to integrate multi-omics data in order to identify and visualize enhancer regions alongside gene expression and other epigenomic modifications. Regulatory network analysis can be done using combinatory approa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bc0badd2ac6ed94fcd578c00aaabb99
https://doi.org/10.1101/2021.08.19.456732
https://doi.org/10.1101/2021.08.19.456732
Autor:
Madeline Rosenberger, Allison Furterer, Lina Pei, Giovanni Coppola, Tatyana Gurlo, Hiroshi Nomoto, Fuying Gao, Q. Wang, Peter C. Butler, Alex M. Mawla, Mark O. Huising
Publikováno v:
SSRN Electronic Journal.
Islets in humans with T2D, and the brain in neurodegenerative disease, share many changes including protein misfolding of amyloidogenic proteins, inflammation, activation of vascular endothelium and dedifferentiation. Islet amyloid characteristic of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd0d7c75af51ca2992221ca4f2479282
https://doi.org/10.2139/ssrn.3635799
https://doi.org/10.2139/ssrn.3635799
Autor:
Mark O. Huising, Alex M. Mawla
Publikováno v:
Diabetes, vol 68, iss 7
Diabetes
Diabetes
Islet gene expression has been widely studied to better understand the transcriptional features that define a healthy β-cell. Transcriptomes of FACS-purified α-, β-, and δ-cells using bulk RNA-sequencing have facilitated our understanding of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44adb2a28fac68a18d1410026c0bdf61
https://escholarship.org/uc/item/3109p6zc
https://escholarship.org/uc/item/3109p6zc