Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Alex M. Chapman"'
Autor:
John T. Randolph, Matthew J. O’Connor, Fei Han, Charles W. Hutchins, Y. Amy Siu, Min Cho, Yunan Zheng, Jonathan A. Hickson, Jana L. Markley, Vlasios Manaves, Mikkel Algire, Kenton A. Baker, Alex M. Chapman, Sujatha M. Gopalakrishnan, Sanjay C. Panchal, Kelly Foster-Duke, DeAnne F. Stolarik, Anita Kempf-Grote, Darby Dammeier, Stacey Fossey, Qi Sun, Chaohong Sun, Yu Shen, Michael J. Dart, Warren M. Kati, Albert Lai, Ari J. Firestone, Michael E. Kort
Publikováno v:
Journal of Medicinal Chemistry. 66:3852-3865
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::941bc4bfb75cae4284f6cb7de0cad715
https://doi.org/10.1021/acs.jmedchem.2c01415
https://doi.org/10.1021/acs.jmedchem.2c01415
Autor:
Alex M. Chapman, Brian R. McNaughton
Publikováno v:
ACS Chemical Biology
Increased cellular levels of protein-protein interactions involving the ankyrin repeat oncoprotein gankyrin are directly linked to aberrant cellular events and numerous cancers. Inhibition of these protein-protein interactions is thus an attractive t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f01db81062f3fba3bfb98d4b259d7f0f
http://europepmc.org/articles/PMC4201333
http://europepmc.org/articles/PMC4201333
Autor:
Alex M. Chapman, Brian R. McNaughton
Protein engineering is an emerging discipline that dovetails modern molecular biology techniques with high-throughput screening, laboratory evolution technologies, and computational approaches to modify sequence, structure, and, in some cases, functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac0a1e2fccd36331b3c2e274a536ff72
https://europepmc.org/articles/PMC4884651/
https://europepmc.org/articles/PMC4884651/
Characterization of the Binding Interaction between the Oncoprotein Gankyrin and a Grafted S6 ATPase
Publikováno v:
Biochemistry
A complex with the C-terminal portion of the proteosomal subunit S6 ATPase is the only available structure of a protein–protein interaction involving the oncoprotein gankyrin. However, difficulties associated with recombinant expression of S6 ATPas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ed4ca5af43e67a36aeefd6a6775f6f2
https://doi.org/10.1021/bi5012354
https://doi.org/10.1021/bi5012354
Autor:
Alex M. Chapman, Brian R. McNaughton
Overexpression of the ankyrin repeat oncoprotein gankyrin is directly linked to the onset, proliferation, and/or metastasis of many cancers. The role of gankyrin in multiple disease-relevant biochemical processes is profound. In addition to other cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af273edc5e80b64426a1bb88eb31e53a
https://europepmc.org/articles/PMC4750872/
https://europepmc.org/articles/PMC4750872/
Publikováno v:
Molecular BioSystems. 8:2036
Split-GFP reassembly is an operationally simple in vivo technique used to identify and study interactions involving proteins and/or peptides. However, the instability of split-GFP fragments and their susceptibility to aggregation place limitations on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db5054f3d2ad330da739741489a38a9c
https://doi.org/10.1039/c2mb25130b
https://doi.org/10.1039/c2mb25130b