Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Alex M. Casella"'
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 9, p e1010430 (2022)
Genetic risk for complex traits is strongly enriched in non-coding genomic regions involved in gene regulation, especially enhancers. However, we lack adequate tools to connect the characteristics of these disruptions to genetic risk. Here, we propos
Externí odkaz:
https://doaj.org/article/fe74c01bdac7451a9264ef12207dc1cf
Autor:
Gurmannat Kalra, Beatrice Milon, Alex M Casella, Brian R Herb, Elizabeth Humphries, Yang Song, Kevin P Rose, Ronna Hertzano, Seth A Ament
Publikováno v:
PLoS Genetics, Vol 16, Iss 9, p e1009025 (2020)
Age-related hearing impairment (ARHI), one of the most common medical conditions, is strongly heritable, yet its genetic causes remain largely unknown. We conducted a meta-analysis of GWAS summary statistics from multiple hearing-related traits in th
Externí odkaz:
https://doaj.org/article/4350f231662f4972a40dd8d76fb52664
Autor:
Nadav Ahituv, Ryan Ziffra, Chang N. Kim, Tychele N. Turner, Amy B. Wilfert, Seth A. Ament, Tomasz J. Nowakowski, Evan E. Eichler, Anat Kreimer, Pawel F. Przytycki, Jayden M. Ross, David Shin, Derek Bogdanoff, Katherine S. Pollard, Kathleen C. Keough, Alex M. Casella, Maximilian Haeussler
Publikováno v:
Nature
Nature, vol 598, iss 7879
Nature, vol 598, iss 7879
During mammalian development, differences in chromatin state coincide with cellular differentiation and reflect changes in the gene regulatory landscape1. In the developing brain, cell fate specification and topographic identity are important for def
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd43e606070686156bafe9aabb16a31a
http://europepmc.org/articles/PMC8494642
http://europepmc.org/articles/PMC8494642
Publikováno v:
PLoS computational biology. 18(9)
Genetic risk for complex traits is strongly enriched in non-coding genomic regions involved in gene regulation, especially enhancers. However, we lack adequate tools to connect the characteristics of these disruptions to genetic risk. Here, we propos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0089083da0fc3766326c8dde5ca99625
https://pubmed.ncbi.nlm.nih.gov/36070311
https://pubmed.ncbi.nlm.nih.gov/36070311
Genetic risk for complex traits is strongly enriched in non-coding genomic regions involved in gene regulation, especially enhancers. However, we lack adequate tools to connect the characteristics of these disruptions to genetic risk. Here, we propos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f3083374b501ab02eaa6e05894f0925
https://doi.org/10.1101/2021.06.14.448418
https://doi.org/10.1101/2021.06.14.448418
Autor:
Chang N. Kim, Pawel F. Przytycki, Tychele N. Turner, Katherine S. Pollard, Seth A. Ament, Ryan Ziffra, Nadav Ahituv, Anat Kreimer, Tomasz J. Nowakowski, Evan E. Eichler, Amy B. Wilfert, Alex M. Casella, Maximilian Haeussler
Dynamic changes in chromatin accessibility coincide with important aspects of neuronal differentiation, such as fate specification and arealization and confer cell type-specific associations to neurodevelopmental disorders. However, studies of the ep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e417f7a6eedb4c3aee0529c6da244035
https://doi.org/10.1101/2019.12.30.891549
https://doi.org/10.1101/2019.12.30.891549
Autor:
Beatrice Milon, Ronna Hertzano, Seth A. Ament, Brian R. Herb, Gurmannat Kalra, Kevin Rose, Alex M. Casella, Yang Song
Age-related hearing impairment (ARHI), one of the most common medical conditions, is strongly heritable, yet its genetic causes remain largely unknown. We conducted a meta-analysis of GWAS summary statistics from multiple hearing-related traits in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c930353e3a45b499f0521dca42b97b0
https://doi.org/10.1101/562405
https://doi.org/10.1101/562405
Autor:
Yang Song, Seth A. Ament, Elizabeth Humphries, Kevin Rose, Beatrice Milon, Brian R. Herb, Gurmannat Kalra, Alex M. Casella, Ronna Hertzano
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 16, Iss 9, p e1009025 (2020)
PLoS Genetics, Vol 16, Iss 9, p e1009025 (2020)
Age-related hearing impairment (ARHI), one of the most common medical conditions, is strongly heritable, yet its genetic causes remain largely unknown. We conducted a meta-analysis of GWAS summary statistics from multiple hearing-related traits in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f48d30ff09e71e337929f8e72206222
https://doi.org/10.1371/journal.pgen.1009025
https://doi.org/10.1371/journal.pgen.1009025
Autor:
Cory C. Funk, Nilufer Ertekin-Taner, Leroy Hood, Matthew A. Richards, Nathan D. Price, Alex Rodriguez, Gustavo Glusman, Yukai Xiao, Alex M. Casella, Segun Jung, Ben Heavner, Ian Foster, Kyle Chard, Paul Shannon, Rory Donovan-Maiye, Carl Kesselman, John D. Van Horn, Todd E. Golde, Arthur W. Toga, Ravi Madduri, Seth A. Ament
Publikováno v:
Cell Rep
There is intense interest in mapping the tissue-specific binding sites of transcription factors in the human genome to reconstruct gene regulatory networks and predict functions for non-coding genetic variation. DNase-seq footprinting provides a mean
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c36b8b6669e7a873f11b92a4d0b1b3e
https://pubmed.ncbi.nlm.nih.gov/32814038
https://pubmed.ncbi.nlm.nih.gov/32814038
Autor:
Paul Shannon, Leroy Hood, Carlo Colantuoni, Bijoya Basu, Cory C. Funk, Alex M. Casella, Nathan D. Price, Jocelynn R. Pearl, Seth A. Ament, Dani E Bergey, Rediet Oshone
Publikováno v:
Cell systems. 8(2)
Summary Transcriptional regulatory changes in the developing and adult brain are prominent features of brain diseases, but the involvement of specific transcription factors (TFs) remains poorly understood. We integrated brain-specific DNase footprint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9ee52ccd4b67c2cec792fc78727eaa9
https://pubmed.ncbi.nlm.nih.gov/30772379
https://pubmed.ncbi.nlm.nih.gov/30772379