Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Alex M, DePaoli"'
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 3, Pp 550-565 (2019)
Fibroblast growth factor (FGF)19, an endocrine hormone produced in the gut, acts in the liver to control bile acid synthesis. NGM282, an engineered FGF19 analog, is currently in clinical development for treating nonalcoholic steatohepatitis. However,
Externí odkaz:
https://doaj.org/article/55c4c128b7544c74abd3f864605e688a
Autor:
Arun J. Sanyal, Lei Ling, Ulrich Beuers, Alex M. DePaoli, Hsiao D. Lieu, Stephen A. Harrison, Gideon M. Hirschfield
Publikováno v:
JHEP Reports, Vol 3, Iss 3, Pp 100255- (2021)
Summary: Background & Aims: Higher serum bile acid levels are associated with an increased risk of cirrhosis and liver-related morbidity and mortality. Herein, we report secondary analyses of aldafermin, an engineered analogue of the gut hormone fibr
Externí odkaz:
https://doaj.org/article/ccc082e5733f41d1b166976e660a219c
Autor:
Marlyn J. Mayo, Alan J. Wigg, Barbara A. Leggett, Hays Arnold, Alexander J. Thompson, Martin Weltman, Elizabeth J. Carey, Andrew J. Muir, Lei Ling, Stephen J. Rossi, Alex M. DePaoli
Publikováno v:
Hepatology Communications, Vol 2, Iss 9, Pp 1037-1050 (2018)
Patients with primary biliary cholangitis (PBC) who had an inadequate response to ursodiol have few treatment options. Alkaline phosphatase (ALP) and bilirubin levels correlate with the risk of liver transplant or death in PBC patients. Fibroblast gr
Externí odkaz:
https://doaj.org/article/4cf97fa6121848f28eac1a691058cf71
Autor:
Lei Ling, Hui Tian, Alex M. DePaoli, R. Marc Learned, Taruna Arora, Xunshan Ding, Mark Humphrey, Hong Yang, Jer-Yuan Hsu, Kalyani Mondal, Darrin A. Lindhout, Van Phung, Xueyan Wang, Mei Zhou
PDF file - 142KB, Supplementary Table S1. Serum Parameters of db/db Mice After Continuous Exposure to FGF19 or M70 for 24 Weeks.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fee3bc699f1740d0952d152d013b5cc
https://doi.org/10.1158/0008-5472.22403538
https://doi.org/10.1158/0008-5472.22403538
Autor:
Duy M. Dinh, Alex M. DePaoli, Rohit Loomba, Stephen A. Harrison, Lei Ling, Arun J. Sanyal, Hsiao D. Lieu
Publikováno v:
Hepatology (Baltimore, Md.)
Background and aims The composition of the human gut microbiota is linked to health and disease, and knowledge of the impact of therapeutics on the microbiota is essential to decipher their biological roles and to gain new mechanistic insights. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a92b03730382f7974ffa62649200b672
https://doi.org/10.1002/hep.31523
https://doi.org/10.1002/hep.31523
Autor:
Stephen A Harrison, Manal F Abdelmalek, Guy Neff, Nadege Gunn, Cynthia D Guy, Naim Alkhouri, Mustafa R Bashir, Bradley Freilich, Anita Kohli, Arun Khazanchi, Muhammad Y Sheikh, Mark Leibowitz, Mary E Rinella, Mohammad S Siddiqui, Mark Kipnes, Sam E Moussa, Ziad H Younes, Meena Bansal, Seth J Baum, Brian Borg, Peter J Ruane, Paul J Thuluvath, Mildred Gottwald, Mujib Khan, Charles Chen, Liza Melchor-Khan, William Chang, Alex M DePaoli, Lei Ling, Hsiao D Lieu
Publikováno v:
The lancet. Gastroenterologyhepatology. 7(7)
Non-alcoholic steatohepatitis (NASH) is characterised by hepatic steatosis, inflammation, and injury, and is associated with an increased risk of liver transplantation and death. NASH affects more than 16 million people in the USA, and there is no ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd1f93b785aa97cf0ab78a3f26ceea07
https://pubmed.ncbi.nlm.nih.gov/35325621
https://pubmed.ncbi.nlm.nih.gov/35325621
Autor:
Manal F. Abdelmalek, Margery A. Connelly, Stephen J. Rossi, Mary E. Rinella, Angelo H. Paredes, Stephen A. Harrison, Lei Ling, James F. Trotter, Mark J. Jaros, Alex M. DePaoli
Publikováno v:
Journal of Hepatology. 70:735-744
NGM282, an engineered analogue of the gut hormone FGF19, improves hepatic steatosis and fibrosis biomarkers in patients with non-alcoholic steatohepatitis (NASH). However, NGM282 increases serum cholesterol levels by inhibiting CYP7A1, which encodes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d440475d2f5b9263073de386028c5b92
https://doi.org/10.1016/j.jhep.2018.11.032
https://doi.org/10.1016/j.jhep.2018.11.032
Autor:
Hsiao D. Lieu, Gideon M. Hirschfield, Arun J. Sanyal, Stephen A. Harrison, Lei Ling, Ulrich Beuers, Alex M. DePaoli
Publikováno v:
JHEP Reports
JHEP Reports, Vol 3, Iss 3, Pp 100255-(2021)
JHEP Reports, 3(3):100255. Elsevier
JHEP Reports, Vol 3, Iss 3, Pp 100255-(2021)
JHEP Reports, 3(3):100255. Elsevier
Summary Background & Aims Higher serum bile acid levels are associated with an increased risk of cirrhosis and liver-related morbidity and mortality. Herein, we report secondary analyses of aldafermin, an engineered analogue of the gut hormone fibrob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba7001e197981d0d939e7dc5af50542f
https://pubmed.ncbi.nlm.nih.gov/33898959
https://pubmed.ncbi.nlm.nih.gov/33898959
Autor:
Hui Tian, Benbo song, Bethany Winans, Darrin A. Lindhout, Mei Zhou, Wei Guo, Hao Wu, Jiping Zha, Mark J. Solloway, Hugo Matern, Zhonghao Liu, Daniel D. Kaplan, Yan Wang, Michael Fox, Husam Younis, Marie Fanget, Ophelia Pedersen, Diana Li, Alex M. DePaoli, Yannan Xi, David Shen, Anna Chen, Iris Ngan, Hong Yang, Avantika Kekatpure, Wenhui Liu, Alan Kutach, Jie Tang, Raj Haldankar, Mark G. Humphrey, Kalyani Mondal
Publikováno v:
SSRN Electronic Journal.
Type 1 Diabetes (T1D) is a chronic disease with potentially severe complications, and β-cell deficiency underlies this disease. Despite active research, no therapy to date has been able to induce β-cell regeneration in humans. Here, we discovered t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba4f36146e0d14cfbdef1799482a61fe
https://doi.org/10.2139/ssrn.3844996
https://doi.org/10.2139/ssrn.3844996
Autor:
Kristin Nelson, Hsiao D. Lieu, Mildred Gottwald, James F. Trotter, Guy W. Neff, Nadege Gunn, Alex M. DePaoli, Sam E. Moussa, Ziad Younes, Andrew Yan, Mustafa R. Bashir, Angelo H. Paredes, Juan P. Frias, William C.G. Chang, Cynthia D. Guy, Stephen A. Harrison, Lei Ling, Anita Kohli
Publikováno v:
Gastroenterology. 160(1)
Background & Aims Aldafermin, an engineered analog of fibroblast growth factor 19, inhibits bile acid synthesis and regulates metabolic homeostasis. We report results from a 24-week, phase 2 study, with serial liver biopsies, of patients with nonalco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d96f50a7c099c529cdf9b6af29ba662
https://pubmed.ncbi.nlm.nih.gov/32781086
https://pubmed.ncbi.nlm.nih.gov/32781086