Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Alex Lipovsky"'
Autor:
Andreea Popa, Wei Zhang, Megan S Harrison, Kylia Goodner, Teymur Kazakov, Edward C Goodwin, Alex Lipovsky, Christopher G Burd, Daniel DiMaio
Publikováno v:
PLoS Pathogens, Vol 11, Iss 2, p e1004699 (2015)
Trafficking of human papillomaviruses to the Golgi apparatus during virus entry requires retromer, an endosomal coat protein complex that mediates the vesicular transport of cellular transmembrane proteins from the endosome to the Golgi apparatus or
Externí odkaz:
https://doaj.org/article/12466746ba26441aa75b0150a96e588c
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94322 (2014)
DNAJB12 and DNAJB14 are transmembrane proteins in the endoplasmic reticulum (ER) that serve as co-chaperones for Hsc70/Hsp70 heat shock proteins. We demonstrate that over-expression of DNAJB12 or DNAJB14 causes the formation of elaborate membranous s
Externí odkaz:
https://doaj.org/article/3512251516924d04817abd64e9aa3892
Autor:
Christian D. S. Nelson, Dan W. Carney, Aaron Derdowski, Alex Lipovsky, Gretchen V. Gee, Bethany O’Hara, Paul Williard, Daniel DiMaio, Jason K. Sello, Walter J. Atwood
Publikováno v:
mBio, Vol 4, Iss 6 (2013)
ABSTRACT Polyomaviruses are ubiquitous pathogens that cause severe disease in immunocompromised individuals. JC polyomavirus (JCPyV) is the causative agent of the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML), whereas B
Externí odkaz:
https://doaj.org/article/20244ec9a75f4271800339dd3e7b07da
Autor:
Edward C. Goodwin, Alex Lipovsky, Takamasa Inoue, Thomas G. Magaldi, Anne P. B. Edwards, Kristin E. Y. Van Goor, Adrienne W. Paton, James C. Paton, Walter J. Atwood, Billy Tsai, Daniel DiMaio
Publikováno v:
mBio, Vol 2, Iss 3 (2011)
ABSTRACT Simian virus 40 (SV40) is a nonenveloped DNA virus that traffics through the endoplasmic reticulum (ER) en route to the nucleus, but the mechanisms of capsid disassembly and ER exit are poorly understood. We conducted an unbiased RNA interfe
Externí odkaz:
https://doaj.org/article/7d5ff50acbcd43f9ac63ba8b338523b9
Autor:
Min Hu, Ryan Duggan, Eric R. Goedken, Heath A. McDonald, Peter F. Slivka, J. Wetter, Marc H Domanus, Anthony Slavin, Sujatha M. Gopalakrishnan, Victoria E. Scott, Marian Namovic, Namjin Chung, Erin Murphy, John Locklear, Chen-Lin Hsieh, Charles Lu, Steven D. Pratt, Alex Lipovsky, Rebecca M. Edelmayer, Jacob King, Diana Donnelly-Roberts
Publikováno v:
ACS Chemical Biology. 14:857-872
Interleukin-17A (IL17A) plays a critical role in the development of numerous autoimmune diseases, including psoriasis. The clinical success of IL17A neutralizing biologics in psoriasis has underlined its importance as a drug discovery target. While m
Autor:
Asu Erden, John W. Schoggins, Alex Lipovsky, Akiko Iwasaki, John D. MacMicking, Clinton J. Bradfield, Daniel DiMaio, Wei Zhang, Mac Crite, Eriko Kanaya
Publikováno v:
Journal of General Virology. 98:2821-2836
Human papillomaviruses (HPVs) are the most common sexually transmitted viruses and one of the most important infectious causes of cancers worldwide. While prophylactic vaccines are effective against certain strains of HPV, established infections stil
Autor:
S.E. Paulsboe, Peter F. Slivka, J. Wetter, Eric R. Goedken, Marian Namovic, Stephen B. Gauld, Alex Lipovsky, Donna Gauvin, Yibing Wang, Zhi Su, Denise Perron, S. McGaraughty
Publikováno v:
Journal of Investigative Dermatology. 141:1772-1779.e6
Psoriasis is a debilitating skin disease characterized by epidermal thickening, abnormal keratinocyte differentiation, and proinflammatory immune cell infiltrate into the affected skin. IL-17A plays a critical role in the etiology of psoriasis. ACT1,
Autor:
Mac Crite, Alex Lipovsky, Clinton J. Bradfield, Daniel DiMaio, Wei Zhang, John D. MacMicking, Asu Erden, Akiko Iwasaki, John W. Schoggins, Eriko Kanaya
Publikováno v:
SSRN Electronic Journal.
Human papillomaviruses (HPVs) are the most common sexually transmitted viruses and one of the most important infectious causes of cancers worldwide. While prophylactic vaccines are effective against certain strains of HPV, established infections stil
Autor:
Julia P. Stevens, Alex Lipovsky, Daniel DiMaio, Teymur Kazakov, Walter J. Atwood, Christian D. S. Nelson, Jason K. Sello, Daniel W. Carney, Bennett D. Ferris
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:4836-4847
Human polyoma- and papillomaviruses are non-enveloped DNA viruses that cause severe pathologies and mortalities. Under circumstances of immunosuppression, JC polyomavirus causes a fatal demyelinating disease called progressive multifocal leukoencepha
Autor:
Stephen B. Gauld, Eric R. Goedken, S.E. Paulsboe, Peter F. Slivka, Yibing Wang, Alex Lipovsky, J. Wetter, Donna Gauvin, Zhi Su, S. McGaraughty, Marian Namovic
Publikováno v:
Journal of Investigative Dermatology. 139:S3