Age and Smoking Related Changes in Metal Ion Levels in Human Lens: Implications for Cataract Formation.

Autor: Alex Langford-Smith, Viranga Tilakaratna, Paul R Lythgoe, Simon J Clark, Paul N Bishop, Anthony J Day

Publikováno v: PLoS ONE, Vol 11, Iss 1, p e0147576 (2016)

Age-related cataract formation is the primary cause of blindness worldwide and although treatable by surgical removal of the lens the majority of sufferers have neither the finances nor access to the medical facilities required. Therefore, a better u

Externí odkaz: https://doaj.org/article/697f9e7192c34982aa456dc55c930c1b

Neuropathology in mouse models of mucopolysaccharidosis type I, IIIA and IIIB.

Autor: Fiona L Wilkinson, Rebecca J Holley, Kia J Langford-Smith, Soumya Badrinath, Aiyin Liao, Alex Langford-Smith, Jonathan D Cooper, Simon A Jones, J Ed Wraith, Rob F Wynn, Catherine L R Merry, Brian W Bigger

Publikováno v: PLoS ONE, Vol 7, Iss 4, p e35787 (2012)

Mucopolysaccharide diseases (MPS) are caused by deficiency of glycosaminoglycan (GAG) degrading enzymes, leading to GAG accumulation. Neurodegenerative MPS diseases exhibit cognitive decline, behavioural problems and shortened lifespan. We have chara

Externí odkaz: https://doaj.org/article/795f2465ae6c40f69f556671f049448c

Genistein improves neuropathology and corrects behaviour in a mouse model of neurodegenerative metabolic disease.

Autor: Marcelina Malinowska, Fiona L Wilkinson, Kia J Langford-Smith, Alex Langford-Smith, Jillian R Brown, Brett E Crawford, Marie T Vanier, Grzegorz Grynkiewicz, Rob F Wynn, J Ed Wraith, Grzegorz Wegrzyn, Brian W Bigger

Publikováno v: PLoS ONE, Vol 5, Iss 12, p e14192 (2010)

BackgroundNeurodegenerative metabolic disorders such as mucopolysaccharidosis IIIB (MPSIIIB or Sanfilippo disease) accumulate undegraded substrates in the brain and are often unresponsive to enzyme replacement treatments due to the impermeability of

Externí odkaz: https://doaj.org/article/bf2a9870d0f24a90bfb8ff75c88c7804

Identification of the haemodynamic environment permissive for plaque erosion

Autor: Yongcheol Kim, Alex Langford-Smith, Michael McElroy, Thomas W Johnson, Giampaolo Niccoli, F.J.H. Gijsen, Filippo Crea, Stephen J. White, Rocco Vergallo, Amir Keshmiri

Publikováno v: McElroy, M, Kim, Y, Niccoli, G, Vergallo, R, Langford-Smith, A, Crea, F, Gijsen, F, Johnson, T, Keshmiri, A & White, S J 2021, ' Identification of the haemodynamic environment permissive for plaque erosion ', Scientific Reports, vol. 11, no. 1, 7253 . https://doi.org/10.1038/s41598-021-86501-x
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports, 11(1):7253. Nature Publishing Group
Scientific Reports
Scientific Reports, 11(1)

Endothelial erosion of atherosclerotic plaques is the underlying cause of approximately 30% of acute coronary syndromes (ACS). As the vascular endothelium is profoundly affected by the haemodynamic environment to which it is exposed, we employed comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8af54e274b75051e6968522318dce3ff
https://doi.org/10.1038/s41598-021-86501-x

Heavy chain-1 of inter-α-inhibitor has an integrin-like structure with immune regulatory activities

Autor: Anthony J. Day, Alex Langford-Smith, Jan J. Enghild, Thomas A. Jowitt, Caroline M. Milner, Cay M. Kielty, David Briggs, Clair Baldock

Inter-α-inhibitor (IαI) is a proteoglycan essential for mammalian reproduction that also plays a less well-characterised role in inflammation. IαI is composed of 2 homologous ‘heavy chains’ (HC1 and HC2) covalently attached to chondroitin sulp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e907105f7793b42e00b0821d6ab9cb80
https://doi.org/10.1101/695700