Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Alex Langford"'
Autor:
Alex Langford-Smith, Viranga Tilakaratna, Paul R Lythgoe, Simon J Clark, Paul N Bishop, Anthony J Day
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147576 (2016)
Age-related cataract formation is the primary cause of blindness worldwide and although treatable by surgical removal of the lens the majority of sufferers have neither the finances nor access to the medical facilities required. Therefore, a better u
Externí odkaz:
https://doaj.org/article/697f9e7192c34982aa456dc55c930c1b
Autor:
Kia J Langford-Smith, Zara Sandiford, Alex Langford-Smith, Fiona L Wilkinson, Simon A Jones, J Ed Wraith, Robert F Wynn, Brian W Bigger
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77632 (2013)
Non-myeloablative allogeneic haematopoietic stem cell transplantation (HSCT) is rarely achievable clinically, except where donor cells have selective advantages. Murine non-myeloablative conditioning regimens have limited clinical success, partly thr
Externí odkaz:
https://doaj.org/article/d4dd05eb1e8b4b4c9bd7225f5277a426
Autor:
Fiona L Wilkinson, Rebecca J Holley, Kia J Langford-Smith, Soumya Badrinath, Aiyin Liao, Alex Langford-Smith, Jonathan D Cooper, Simon A Jones, J Ed Wraith, Rob F Wynn, Catherine L R Merry, Brian W Bigger
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35787 (2012)
Mucopolysaccharide diseases (MPS) are caused by deficiency of glycosaminoglycan (GAG) degrading enzymes, leading to GAG accumulation. Neurodegenerative MPS diseases exhibit cognitive decline, behavioural problems and shortened lifespan. We have chara
Externí odkaz:
https://doaj.org/article/795f2465ae6c40f69f556671f049448c
Autor:
Alex Langford-Smith, Kia J Langford-Smith, Simon A Jones, Robert F Wynn, J E Wraith, Fiona L Wilkinson, Brian W Bigger
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25717 (2011)
Reliable behavioural tests in animal models of neurodegenerative diseases allow us to study the natural history of disease and evaluate the efficacy of novel therapies. Mucopolysaccharidosis IIIA (MPS IIIA or Sanfilippo A), is a severe, neurodegenera
Externí odkaz:
https://doaj.org/article/2b1f553339224667a2bfb61a6db10641
Autor:
Marcelina Malinowska, Fiona L Wilkinson, Kia J Langford-Smith, Alex Langford-Smith, Jillian R Brown, Brett E Crawford, Marie T Vanier, Grzegorz Grynkiewicz, Rob F Wynn, J Ed Wraith, Grzegorz Wegrzyn, Brian W Bigger
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e14192 (2010)
BackgroundNeurodegenerative metabolic disorders such as mucopolysaccharidosis IIIB (MPSIIIB or Sanfilippo disease) accumulate undegraded substrates in the brain and are often unresponsive to enzyme replacement treatments due to the impermeability of
Externí odkaz:
https://doaj.org/article/bf2a9870d0f24a90bfb8ff75c88c7804
Autor:
Sandro Satta, Robert Beal, Rhys Smith, Xing Luo, Glenn R Ferris, Alex Langford-Smith, Jack Teasdale, Tom Tanjeko Ajime, Jef Serré, Georgina Hazell, Graciela Sala Newby, Jason L Johnson, Svitlana Kurinna, Martin J Humphries, Ghislaine Gayan-Ramirez, Peter Libby, Hans Degens, Bo Yu, Thomas Johnson, Yvonne Alexander, Haibo Jia, Andrew C Newby, Stephen J White
Publikováno v:
Cardiovascular Research.
AimsEndothelial erosion of plaques is responsible for ∼30% of acute coronary syndromes (ACS). Smoking is a risk factor for plaque erosion, which most frequently occurs on the upstream surface of plaques where the endothelium experiences elevated sh
Publikováno v:
Drying Technologies for Biotechnology and Pharmaceutical Applications. :1-7
Publikováno v:
Practical Aspects of Vaccine Development ISBN: 9780128143575
Aluminum-containing adjuvants are commonly used in vaccines to elicit an enhanced immune response in patients. The structure and surface characteristics of aluminum-containing adjuvants govern their interaction with antigens and its formation of anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1af2b5fc81c4a8f4aeae3d154817de4e
https://doi.org/10.1016/b978-0-12-814357-5.00008-8
https://doi.org/10.1016/b978-0-12-814357-5.00008-8
Autor:
Mansoor M. Amiji, Salvador F. Ausar, Deep Bhattacharya, Michael Bruchsaler, Valeria Caputo, Roberta Antonia Diotti, Kanwal Gill, Sonia Gregory, Jianxin Guo, Manish Gupta, Akshay Jain, Parag Kolhe, Vamsi Krishna, Alex Langford, Nicholas R. Larson, Aaron Latal, Rushit N. Lodaya, Malte Meppen, C. Russell Middaugh, Leanne Minall, Paul Nelson, Derek T. O'Hagan, Katherine E. Odneal, Adora M. Padilla, Nicole M. Payton, Aslin Rodriguez Nassif, Giuseppe Andrea Sautto, Lee C. Smith, Daniela Stranges, Yangjie Wei, Chris Wiley
Publikováno v:
Practical Aspects of Vaccine Development ISBN: 9780128143575
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9774071f5ea9416d524ecd15701c745
https://doi.org/10.1016/b978-0-12-814357-5.01002-3
https://doi.org/10.1016/b978-0-12-814357-5.01002-3
Publikováno v:
Pharmaceutical research. 39(3)
The viscosity of highly concentrated therapeutic monoclonal antibody (mAb) formulations at concentrations ≥ 100 mg/mL can significantly affect the stability, processing, and drug product development for subcutaneous delivery. An early identificatio