Výsledky vyhledávání - "Alex L. Nigg"

Akademický článek

The deleted in oral cancer (DOC1 aka CDK2AP1) tumor suppressor gene is downregulated in oral squamous cell carcinoma by multiple microRNAs

Autor: Roberto Stabile, Mario Román Cabezas, Mathijs P. Verhagen, Francesco A. Tucci, Thierry P. P. van den Bosch, Maria J. De Herdt, Berdine van der Steen, Alex L. Nigg, Meng Chen, Cristina Ivan, Masayoshi Shimizu, Senada Koljenović, Jose A. Hardillo, C. Peter Verrijzer, Robert J. Baatenburg de Jong, George A. Calin, Riccardo Fodde

Publikováno v: Cell Death and Disease, Vol 14, Iss 5, Pp 1-13 (2023)

Abstract Cyclin-dependent kinase 2-associated protein 1 (CDK2AP1; also known as deleted in oral cancer or DOC1) is a tumor suppressor gene known to play functional roles in both cell cycle regulation and in the epigenetic control of embryonic stem ce

Externí odkaz: https://doaj.org/article/f7824d98a84b4c1d9d47b1294a00ba7e

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Akademický článek

Growth factor dependent changes in nanoscale architecture of focal adhesions

Autor: Karin Legerstee, Tsion E. Abraham, Wiggert A. van Cappellen, Alex L. Nigg, Johan A. Slotman, Adriaan B. Houtsmuller

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

Abstract Focal adhesions (FAs) are flat elongated structures that mediate cell migration and link the cytoskeleton to the extracellular matrix. Along the vertical axis FAs were shown to be composed of three layers. We used structured illumination mic

Externí odkaz: https://doaj.org/article/04042c18fbe1426ea391cb28c528894f

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Akademický článek

Identifying Molecular Changes in Early Cervical Cancer Samples of Patients That Developed Metastasis

Autor: Vera de Geus, Patricia C. Ewing-Graham, Willem de Koning, Maurits N. C. de Koning, Thierry P. P. van den Bosch, Alex L. Nigg, Casper H. J. van Eijck, Marta Jozwiak, Heleen J. van Beekhuizen, Dana A. M. Mustafa

Publikováno v: Frontiers in Oncology, Vol 11 (2022)

Cervical cancer is one of the most common cancers in women worldwide. Patients diagnosed with early-stage cervical cancer have a good prognosis, however, 10-20% suffer from local or distant recurrent disease after primary treatment. Treatment options

Externí odkaz: https://doaj.org/article/83c09f01613e4e1dbc7b273099940269

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Akademický článek

Differentiating Cerebellar Impact on Thalamic Nuclei

Autor: Simona V. Gornati, Carmen B. Schäfer, Oscar H.J. Eelkman Rooda, Alex L. Nigg, Chris I. De Zeeuw, Freek E. Hoebeek

Publikováno v: Cell Reports, Vol 23, Iss 9, Pp 2690-2704 (2018)

The cerebellum plays a role in coordination of movements and non-motor functions. Cerebellar nuclei (CN) axons connect to various parts of the thalamo-cortical network, but detailed information on the characteristics of cerebello-thalamic connections

Externí odkaz: https://doaj.org/article/7958ff97741b40bd9eafa8a7509b0b4a

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Akademický článek

Immunomics of Renal Allograft Acute T Cell-Mediated Rejection Biopsies of Tacrolimus- and Belatacept-Treated Patients

Autor: Marieke van der Zwan, MD, Carla C. Baan, PhD, Robert B. Colvin, MD, PhD, Rex N. Smith, MD, PhD, Rebecca A. White, Dorothy Ndishabandi, Alex L. Nigg, Thierry P.P. van den Bosch, PhD, Gretchen N. de Graav, MD, PhD, Marian C. Clahsen-van Groningen, MD, PhD, Dennis A. Hesselink, MD, PhD

Publikováno v: Transplantation Direct, Vol 5, Iss 1, p e418 (2019)

Background. Belatacept-based therapy in kidney transplant recipient has been shown to increase long-term renal allograft and patient survival compared with calcineurin inhibitor–based therapy, however, with an increased risk of acute T cell-mediate

Externí odkaz: https://doaj.org/article/932b155d9b794b31a623b1ecca59389a

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Akademický článek

Inefficient DNA Repair Is an Aging-Related Modifier of Parkinson’s Disease

Autor: Sara Sepe, Chiara Milanese, Sylvia Gabriels, Kasper W.J. Derks, Cesar Payan-Gomez, Wilfred F.J. van IJcken, Yvonne M.A. Rijksen, Alex L. Nigg, Sandra Moreno, Silvia Cerri, Fabio Blandini, Jan H.J. Hoeijmakers, Pier G. Mastroberardino

Publikováno v: Cell Reports, Vol 15, Iss 9, Pp 1866-1875 (2016)

The underlying relation between Parkinson’s disease (PD) etiopathology and its major risk factor, aging, is largely unknown. In light of the causative link between genome stability and aging, we investigate a possible nexus between DNA damage accum

Externí odkaz: https://doaj.org/article/7126e1c82c7a4a0aa0b46f30f13acd3f

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Growth factor dependent changes in nanoscale architecture of focal adhesions

Autor: Johan A. Slotman, Tsion E Abraham, Wiggert A. van Cappellen, Adriaan B. Houtsmuller, Karin Legerstee, Alex L. Nigg

Publikováno v: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports, 11(1):2315. Nature Publishing Group

Focal adhesions (FAs) are flat elongated structures that mediate cell migration and link the cytoskeleton to the extracellular matrix. Along the vertical axis FAs were shown to be composed of three layers. We used structured illumination microscopy t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac43cdbfbb43afec40c1519698e6a86
https://doi.org/10.1038/s41598-021-81898-x

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Differentiating Cerebellar Impact on Thalamic Nuclei

Autor: Freek E. Hoebeek, Oscar H J Eelkman Rooda, Alex L. Nigg, Simona V. Gornati, Chris I. De Zeeuw, Carmen B. Schäfer

Publikováno v: Cell Reports [E], 23(9), 2690. Cell Press
Cell Reports, Vol 23, Iss 9, Pp 2690-2704 (2018)
Cell Reports, 23(9), 2690-2704. Cell Press
Cell Reports

Summary The cerebellum plays a role in coordination of movements and non-motor functions. Cerebellar nuclei (CN) axons connect to various parts of the thalamo-cortical network, but detailed information on the characteristics of cerebello-thalamic con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c2d5fe9fb1c02e17dc6be615b1e7a6d
https://doi.org/10.1016/j.celrep.2018.04.098

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Prognostic value of intra-tumoral CD8(+)/FoxP3(+) lymphocyte ratio in patients with resected colorectal cancer liver metastasis

Autor: Bettina E. Hansen, Guoying Zhou, Marco J. Bruno, Kostandinos Sideras, Boris Galjart, Cornelis Verhoef, Katharina Biermann, Stefan Sleijfer, Shanta Mancham, Dave Sprengers, H. Stoop, Angela Vasaturo, Jaap Kwekkeboom, Alexander Pedroza-Gonzalez, Alex L. Nigg

Publikováno v: Journal of Surgical Oncology, 118(1), 68-76. Wiley-Liss Inc.

Background and objectives Patients with isolated colorectal-cancer-liver-metastases (CRCLM) frequently undergo metastatectomy. Tumor-infiltrating-lymphocytes (TILs) have prognostic potential in the setting of primary colorectal cancer, however, their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::624c9f01aab6027015772b7339b00f09
https://doi.org/10.1002/jso.25091

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DSPC or DPPC As Main Shell Component Influences Ligand Distribution and Binding Area of Lipid‐Coated Targeted Microbubbles

Autor: Ilya Skachkov, Antonius F.W. van der Steen, Tom J. A. Kokhuis, Alex L. Nigg, Nico de Jong, Klazina Kooiman, Wiggert A. van Cappellen, Johannes G. Bosch, Tom van Rooij

Publikováno v: European Journal of Lipid Science and Technology, 116(9), 1217-1227. Wiley-VCH

Ultrasound contrast agents (UCA) consist of gas-filled coated microbubbles with diameters of 1–10 µm. Targeted UCA can bind to biomarkers associated with disease through coating-incorporated ligands, making ultrasound molecular imaging possible. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28b8da883cb18503b8c338d76f962037
https://doi.org/10.1002/ejlt.202100034

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