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pro vyhledávání: '"Alex L. Bingcang"'
Autor:
Kimberly A. Fraley, David Bom, Stephen G. Zimmer, Lori J. Latus, Stefan Kruszewski, Ashok J. Chavan, Thomas G. Burke, Dennis P. Curran, Wu Du, Glenda Kohlhagen, Yves Pommier, J. Thompson Strode, Alex L. Bingcang
Publikováno v:
Journal of Medicinal Chemistry. 43:3970-3980
We describe the rational design and synthesis of B- and A, B-ring-modified camptothecins. The key alpha-hydroxy-delta-lactone pharmacophore in 7-tert-butyldimethylsilyl-10-hydroxycamptothecin (DB-67, 14) displays superior stability in human blood whe