Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Alex L Wilkinson"'
Autor:
James I. Kennedy, Scott P. Davies, Peter W. Hewett, Alex L. Wilkinson, Ye H. Oo, Wei-Yu Lu, Alicia J. El Haj, Shishir Shetty
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Immunotherapy has changed the landscape of treatment options for patients with hepatocellular cancer. Checkpoint inhibitors are now standard of care for patients with advanced tumours, yet the majority remain resistant to this therapy and urgent appr
Externí odkaz:
https://doaj.org/article/a2ab91cef8bf48c791a2da90a324bdec
Autor:
Chinaemerem U. Onyishi, Guillaume E. Desanti, Alex L. Wilkinson, Samuel Lara-Reyna, Eva-Maria Frickel, Gyorgy Fejer, Olivier D. Christophe, Clare E. Bryant, Subhankar Mukhopadhyay, Siamon Gordon, Robin C. May
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract The opportunistic fungal pathogen Cryptococcus neoformans causes lethal infections in immunocompromised patients. Macrophages are central to the host response to cryptococci; however, it is unclear how C. neoformans is recognised and phagocy
Externí odkaz:
https://doaj.org/article/d574524e28824efda336edb4bafa128e
Autor:
Alex L. Wilkinson, Samuel Hulme, James I. Kennedy, Emily R. Mann, Paul Horn, Emma L. Shepherd, Kelvin Yin, Marco Y.W. Zaki, Gareth Hardisty, Wei-Yu Lu, Pia Rantakari, David H. Adams, Marko Salmi, Matthew Hoare, Daniel A. Patten, Shishir Shetty
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107966- (2023)
Summary: Liver sinusoidal endothelial cells (LSEC) undergo significant phenotypic change in chronic liver disease (CLD), and yet the factors that drive this process and the impact on their function as a vascular barrier and gatekeeper for immune cell
Externí odkaz:
https://doaj.org/article/58c0bb4699c74d3e8cde69d28ccda647
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Scavenger receptor class F member 1 (SCARF1) is thought to play an important role in the selective recruitment of CD4+ T cells to liver sinusoidal endothelial cells during chronic liver disease. However, the contribution of SCARF1 to hepatocellular c
Externí odkaz:
https://doaj.org/article/2c015d47f05f4f6381a5be0bfcf67f22
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Liver sinusoidal endothelial cells (LSEC) form a unique barrier between the liver sinusoids and the underlying parenchyma, and thus play a crucial role in maintaining metabolic and immune homeostasis, as well as actively contributing to disease patho
Externí odkaz:
https://doaj.org/article/0797c94381e54dbb9a3cb89a8e81413f
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The liver is our largest internal organ and it plays major roles in drug detoxification and immunity, where the ingestion of extracellular material through phagocytosis is a critical pathway. Phagocytosis is the deliberate endocytosis of large partic
Externí odkaz:
https://doaj.org/article/37c3c79d44ea41358da052269f2ca922
Autor:
Scott P. Davies, Gary M. Reynolds, Alex L. Wilkinson, Xiaoyan Li, Rebecca Rose, Maanav Leekha, Yuxin S. Liu, Ratnam Gandhi, Emma Buckroyd, Joe Grove, Nicholas M. Barnes, Robin C. May, Stefan G. Hubscher, David H. Adams, Yuehua Huang, Omar Qureshi, Zania Stamataki
Publikováno v:
Cell Reports, Vol 29, Iss 6, Pp 1610-1620.e4 (2019)
Summary: CD4+ T cells play critical roles in directing immunity, both as T helper and as regulatory T (Treg) cells. Here, we demonstrate that hepatocytes can modulate T cell populations through engulfment of live CD4+ lymphocytes. We term this phenom
Externí odkaz:
https://doaj.org/article/2b671f8f1a2b4c1790afe5719dc2460b
Autor:
Chinaemerem U. Onyishi, Guillaume E. Desanti, Alex L. Wilkinson, Gyorgy Fejer, Olivier D. Christophe, Clare E. Bryant, Subhankar Mukhopadhyay, Siamon Gordon, Robin C. May
The opportunistic fungal pathogenCryptococcus neoformanscauses lethal infections in immunocompromised patients. Macrophages are central to the host response to cryptococci; however, it is unclear howC. neoformansis recognized and phagocytosed by macr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c336b0aeb8af34d7dd8ab55ba1cfbf17
https://doi.org/10.1101/2023.01.30.525903
https://doi.org/10.1101/2023.01.30.525903
Publikováno v:
Seminars in Liver Disease. 42:061-076
The scavenger receptor superfamily represents a highly diverse collection of evolutionarily-conserved receptors which are known to play key roles in host homeostasis, the most prominent of which is the clearance of unwanted endogenous macromolecules,
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 376:273-280
The arginyl-glycinyl-aspartic acid (RGD) integrin alpha-v beta-6 (αvβ6) has been identified as playing a key role in the activation of transforming growth factor-β (TGFβ) that is hypothesized to be pivotal in the development of fibrosis and other