Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Alex Klug"'
Autor:
Sonali Jindal, Nathan D. Pennock, Alex Klug, Jayasri Narasimhan, Andrea Calhoun, Michelle R. Roberts, Rulla M. Tamimi, A. Heather Eliassen, Sheila Weinmann, Virginia F. Borges, Pepper Schedin
Publikováno v:
npj Breast Cancer, Vol 6, Iss 1, Pp 1-10 (2020)
Abstract Immunohistochemical (IHC) staining in breast cancer shows both gain and loss of COX2 expression with disease risk and progression. We investigated four common COX2 antibody clones and found high specificity for purified human COX2 for three
Externí odkaz:
https://doaj.org/article/129419c4a8544d358cac1ef1e1e746bd
Autor:
Benjamin J. Burwitz, Jochen M. Wettengel, Martin A. Mück-Häusl, Marc Ringelhan, Chunkyu Ko, Marvin M. Festag, Katherine B. Hammond, Mina Northrup, Benjamin N. Bimber, Thomas Jacob, Jason S. Reed, Reed Norris, Byung Park, Sven Moller-Tank, Knud Esser, Justin M. Greene, Helen L. Wu, Shaheed Abdulhaqq, Gabriela Webb, William F. Sutton, Alex Klug, Tonya Swanson, Alfred W. Legasse, Tania Q. Vu, Aravind Asokan, Nancy L. Haigwood, Ulrike Protzer, Jonah B. Sacha
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Hepatitis B virus (HBV) has a limited host range and current animal models can only recapitulate certain aspects of HBV replication. Here, the authors show that expression of the HBV receptor NTCP in macaques supports HBV replication in vivo, suggest
Externí odkaz:
https://doaj.org/article/2039d96647514d3c9a3deb587404ab5a
Autor:
Benjamin J Burwitz, Daniel Malouli, Benjamin N Bimber, Jason S Reed, Abigail B Ventura, Meaghan H Hancock, Luke S Uebelhoer, Amruta Bhusari, Katherine B Hammond, Renee G Espinosa Trethewy, Alex Klug, Alfred W Legasse, Michael K Axthelm, Jay A Nelson, Byung S Park, Daniel N Streblow, Scott G Hansen, Louis J Picker, Klaus Früh, Jonah B Sacha
Publikováno v:
PLoS Pathogens, Vol 12, Iss 11, p e1006014 (2016)
Cytomegaloviruses (CMV) are highly species-specific due to millennia of co-evolution and adaptation to their host, with no successful experimental cross-species infection in primates reported to date. Accordingly, full genome phylogenetic analysis of
Externí odkaz:
https://doaj.org/article/7f89ac2e54d24ee7a16db764f546ae92
Autor:
Sarah M. Bernhardt, Elizabeth Mitchell, Stephanie Stamnes, Reuben J. Hoffmann, Andrea Calhoun, Alex Klug, Tanya D. Russell, Nathan D. Pennock, Joshua M. Walker, Pepper Schedin
Publikováno v:
Cancers; Volume 15; Issue 8; Pages: 2257
In breast cancer, progression to invasive ductal carcinoma (IDC) involves interactions between immune, myoepithelial, and tumor cells. Development of IDC can proceed through ductal carcinoma in situ (DCIS), a non-obligate, non-invasive stage, or IDC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7469375640e927c384e314fb943ddf32
https://doi.org/10.3390/cancers15082257
https://doi.org/10.3390/cancers15082257
Autor:
Sarah Margaret Bernhardt, Elizabeth Mitchell, Stephanie Stamnes, Andrea Calhoun, Alex Klug, Tanya Russell, Pepper Schedin
Background: The incidence of ductal carcinoma in situ (DCIS), a pre-invasive malignancy of the breast, has increased sharply in the U.S. following routine mammographic screening. Since not all DCIS progress to invasive ductal cancer (IDC), identifyin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b3d9092208eb5451bad6db40ae8a667
https://doi.org/10.21203/rs.3.rs-1620339/v1
https://doi.org/10.21203/rs.3.rs-1620339/v1
Autor:
A. Heather Eliassen, Alex Klug, Jayasri Narasimhan, Nathan D. Pennock, Andrea Calhoun, Virginia F. Borges, Sheila Weinmann, Rulla M. Tamimi, Sonali Jindal, Pepper Schedin, Michelle Roberts
Publikováno v:
npj Breast Cancer, Vol 6, Iss 1, Pp 1-10 (2020)
NPJ Breast Cancer
NPJ Breast Cancer
Immunohistochemical (IHC) staining in breast cancer shows both gain and loss of COX2 expression with disease risk and progression. We investigated four common COX2 antibody clones and found high specificity for purified human COX2 for three clones; h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::466f5c7b3813f97b23da765bbde495ec
https://doaj.org/article/129419c4a8544d358cac1ef1e1e746bd
https://doaj.org/article/129419c4a8544d358cac1ef1e1e746bd
Publikováno v:
Cancers
Volume 13
Issue 7
Cancers, Vol 13, Iss 1698, p 1698 (2021)
Volume 13
Issue 7
Cancers, Vol 13, Iss 1698, p 1698 (2021)
Simple Summary Cancer becomes lethal when it metastasizes to secondary sites, and for breast cancer metastasis to the liver is a serious clinical problem. Liver metastasis is promoted, in part, by changes to the liver environment, resulting in the fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39479e033486b65fefdb19a16768b09c
Autor:
Shaheed A. Abdulhaqq, Justin M. Greene, Aravind Asokan, Katherine B. Hammond, Jochen M. Wettengel, Gabriela M. Webb, Alfred W. Legasse, William F. Sutton, Jonah B. Sacha, Marc Ringelhan, Marvin M. Festag, Thomas Jacob, Chunkyu Ko, Reed A. Norris, Sven Moller-Tank, Martin A. Mück-Häusl, Tania Q. Vu, Byung Park, Nancy L. Haigwood, Mina Northrup, Alex Klug, Benjamin N. Bimber, Benjamin J. Burwitz, Ulrike Protzer, Tonya Swanson, Knud Esser, Helen L. Wu, Jason S. Reed
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Nature Communications
Nat. Commun. 8:2146 (2017)
Nature Communications
Nat. Commun. 8:2146 (2017)
Hepatitis B virus (HBV) is a major global health concern, and the development of curative therapeutics is urgently needed. Such efforts are impeded by the lack of a physiologically relevant, pre-clinical animal model of HBV infection. Here, we report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cb335eb7fa39e5edb40f6267779a7a8
http://link.springer.com/article/10.1038/s41467-017-01953-y
http://link.springer.com/article/10.1038/s41467-017-01953-y
Autor:
Jay A. Nelson, Scott G. Hansen, Abigail B. Ventura, Katherine B. Hammond, Meaghan H. Hancock, Amruta Bhusari, Louis J. Picker, Klaus Früh, Daniel Malouli, Alfred W. Legasse, Byung Park, Alex Klug, Luke S. Uebelhoer, Michael K. Axthelm, Benjamin N. Bimber, Renee G. Espinosa Trethewy, Daniel N. Streblow, Jason S. Reed, Jonah B. Sacha, Benjamin J. Burwitz
Publikováno v:
PLoS Pathogens, Vol 12, Iss 11, p e1006014 (2016)
PLoS Pathogens
PLoS Pathogens
Cytomegaloviruses (CMV) are highly species-specific due to millennia of co-evolution and adaptation to their host, with no successful experimental cross-species infection in primates reported to date. Accordingly, full genome phylogenetic analysis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40aefb8c2582aebfaea2da960e01f426
https://doi.org/10.1371/journal.ppat.1006014
https://doi.org/10.1371/journal.ppat.1006014
Publikováno v:
Chemical research in toxicology. 25(3)
DNA-interstrand cross-links (ICLs) can be repaired by biochemical pathways requiring DNA polymerases that are capable of translesion DNA synthesis (TLS). The anticipated function of TLS polymerases in these pathways is to insert nucleotides opposite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7295ae89581354cb16ebb101c4d697d2
https://pubmed.ncbi.nlm.nih.gov/22332732
https://pubmed.ncbi.nlm.nih.gov/22332732