Výsledky vyhledávání - "Alex Kertser"

Akademický článek

PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model

Autor: Neta Rosenzweig, Raz Dvir-Szternfeld, Afroditi Tsitsou-Kampeli, Hadas Keren-Shaul, Hila Ben-Yehuda, Pierre Weill-Raynal, Liora Cahalon, Alex Kertser, Kuti Baruch, Ido Amit, Assaf Weiner, Michal Schwartz

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)

Blocking the PD-1 pathway was shown to be effective in amyloid beta mouse models, yet little is known about its therapeutic potential in models of tauopathy. The authors show here that blocking PD-L1, a PD-1 ligand, is similarly effective, and that b

Externí odkaz: https://doaj.org/article/b5d1dae5c110405690c42c4d4f5633f9

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PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model

Autor: Hila Ben-Yehuda, Ido Amit, Hadas Keren-Shaul, Neta Rosenzweig, Kuti Baruch, Assaf Weiner, Michal Schwartz, Liora Cahalon, Afroditi Tsitsou-Kampeli, Raz Dvir-Szternfeld, Pierre Weill-Raynal, Alex Kertser

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications

Alzheimer’s disease (AD) is a heterogeneous disorder with multiple etiologies. Harnessing the immune system by blocking the programmed cell death receptor (PD)-1 pathway in an amyloid beta mouse model was shown to evoke a sequence of immune respons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72e387b61bd75c8ad157b114f3ea2221
https://doaj.org/article/b5d1dae5c110405690c42c4d4f5633f9

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