Zobrazeno 1 - 10
of 166
pro vyhledávání: '"Alex Kentsis"'
Autor:
André Almeida, Sara T'Sas, Luca Pagliaro, Igor Fijalkowski, Wouter Sleeckx, Hannah Van Steenberge, Raffaella Zamponi, Béatrice Lintermans, Wouter Van Loocke, Bruno Palhais, Alexandra Reekmans, Valentina Bardelli, Lisa Demoen, Lindy Reunes, Dieter Deforce, Filip Van Nieuwerburgh, Alex Kentsis, Panagiotis Ntziachristos, Nadine Van Roy, Barbara De Moerloose, Cristina Mecucci, Roberta La Starza, Giovanni Roti, Steven Goossens, Pieter Van Vlierberghe, Tim Pieters
Publikováno v:
HemaSphere, Vol 8, Iss 3, Pp n/a-n/a (2024)
Abstract T‐lineage acute lymphoblastic leukemia (T‐ALL) is an aggressive hematological malignancy that accounts for 10%–15% of pediatric and 25% of adult ALL cases. Although the prognosis of T‐ALL has improved over time, the outcome of T‐AL
Externí odkaz:
https://doaj.org/article/08e4e181348c41af8c6b27ded628bcc2
Autor:
Stéphane Van Haver, Yujie Fan, Sarah-Lee Bekaert, Celine Everaert, Wouter Van Loocke, Vittorio Zanzani, Joke Deschildre, Inés Fernandez Maestre, Adrianna Amaro, Vanessa Vermeirssen, Katleen De Preter, Ting Zhou, Alex Kentsis, Lorenz Studer, Frank Speleman, Stephen S. Roberts
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108096- (2024)
Summary: Studies defining normal and disrupted human neural crest cell development have been challenging given its early timing and intricacy of development. Consequently, insight into the early disruptive events causing a neural crest related diseas
Externí odkaz:
https://doaj.org/article/7a4a8a6eb06847588402732e66ef624f
Autor:
Florisela Herrejon Chavez, Hanzhi Luo, Paolo Cifani, Alli Pine, Eren L. Chu, Suhasini Joshi, Ersilia Barin, Alexandra Schurer, Mandy Chan, Kathryn Chang, Grace Y. Q. Han, Aspen J. Pierson, Michael Xiao, Xuejing Yang, Lindsey M. Kuehm, Yuning Hong, Diu T. T. Nguyen, Gabriela Chiosis, Alex Kentsis, Christina Leslie, Ly P. Vu, Michael G. Kharas
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Tissue homeostasis is maintained after stress by engaging and activating the hematopoietic stem and progenitor compartments in the blood. Hematopoietic stem cells (HSCs) are essential for long-term repopulation after secondary transplantatio
Externí odkaz:
https://doaj.org/article/a849e3d3deda463181789ab17c11b2cd
Publikováno v:
iScience, Vol 19, Iss , Pp 74-82 (2019)
Summary: Whole-genome doubling (WGD) is common early in tumorigenesis. WGD doubles ploidy and centrosome number. In the ensuing mitoses, excess centrosomes form a multipolar spindle, resulting in a lethal multipolar cell division. To survive, cells m
Externí odkaz:
https://doaj.org/article/b45a33f8947f4ff7849b0c0c4ff6e949
Autor:
Sumiko Takao, Lauren Forbes, Masahiro Uni, Shuyuan Cheng, Jose Mario Bello Pineda, Yusuke Tarumoto, Paolo Cifani, Gerard Minuesa, Celine Chen, Michael G Kharas, Robert K Bradley, Christopher R Vakoc, Richard P Koche, Alex Kentsis
Publikováno v:
eLife, Vol 10 (2021)
Dysregulated gene expression contributes to most prevalent features in human cancers. Here, we show that most subtypes of acute myeloid leukemia (AML) depend on the aberrant assembly of MYB transcriptional co-activator complex. By rapid and selective
Externí odkaz:
https://doaj.org/article/2d4ce356cf4040e3ac6e28874adae061
Autor:
Alex Kentsis, Steven A. Frank
Publikováno v:
Frontiers in Pediatrics, Vol 8 (2020)
A new hypothesis suggests that somatic genome remodeling during normal development can cause mutations that explain many early onset cancers in children and adults.
Externí odkaz:
https://doaj.org/article/65921a2040974f629c11d472f6441ced
Autor:
Kavitha Ramaswamy, Lauren Forbes, Gerard Minuesa, Tatyana Gindin, Fiona Brown, Michael G. Kharas, Andrei V. Krivtsov, Scott A. Armstrong, Eric Still, Elisa de Stanchina, Birgit Knoechel, Richard Koche, Alex Kentsis
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
MYB activity is a key factor for the maintenance of acute myeloid leukemias but it is also a difficult target. Here, the authors develop a peptidomimetic (MYBMIM) that prevents the interaction of the trans-activation domain of MYB with the KIX domain
Externí odkaz:
https://doaj.org/article/a470abd9ea4643cfb47136bbe875cfb7
Autor:
Jeffrey A. Rosenfeld, Darryl Reeves, Mercer R. Brugler, Apurva Narechania, Sabrina Simon, Russell Durrett, Jonathan Foox, Kevin Shianna, Michael C. Schatz, Jorge Gandara, Ebrahim Afshinnekoo, Ernest T. Lam, Alex R. Hastie, Saki Chan, Han Cao, Michael Saghbini, Alex Kentsis, Paul J. Planet, Vladyslav Kholodovych, Michael Tessler, Richard Baker, Rob DeSalle, Louis N. Sorkin, Sergios-Orestis Kolokotronis, Mark E. Siddall, George Amato, Christopher E. Mason
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
The common bedbug is a pest for humans, yet its molecular biology is poorly understood. Here, the authors sequence the common bedbug genome and profile gene expression across all life stages to show major changes in gene expression after feeding on h
Externí odkaz:
https://doaj.org/article/9e90b05e34774654884e772c7b115e14
Autor:
Anton G Henssen, Elizabeth Henaff, Eileen Jiang, Amy R Eisenberg, Julianne R Carson, Camila M Villasante, Mondira Ray, Eric Still, Melissa Burns, Jorge Gandara, Cedric Feschotte, Christopher E Mason, Alex Kentsis
Publikováno v:
eLife, Vol 4 (2015)
Transposons are mobile genetic elements that are found in nearly all organisms, including humans. Mobilization of DNA transposons by transposase enzymes can cause genomic rearrangements, but our knowledge of human genes derived from transposases is l
Externí odkaz:
https://doaj.org/article/1ed8590329114e52b9748891faecfd2a
Autor:
George S. Laszlo, Todd A. Alonzo, Chelsea J. Gudgeon, Kimberly H. Harrington, Alex Kentsis, Robert B. Gerbing, Yi-Cheng Wang, Rhonda E. Ries, Susana C. Raimondi, Betsy A. Hirsch, Alan S. Gamis, Soheil Meshinchi, Roland B. Walter
Publikováno v:
Journal of Hematology & Oncology, Vol 9, Iss 1, Pp 1-1 (2016)
Externí odkaz:
https://doaj.org/article/c828f6641677447fbb89446fcb0c0f60