Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Alex K, Lyashchenko"'
Autor:
Jeremy R. Beitler, Shelief Y Robbins-Juarez, Kevin L. Delucchi, Matthew J. Cummings, Kristin M. Burkart, Darryl Abrams, Daniel Brodie, Pratik Sinha, Natalie H Yip, Cara Agerstrand, Manoj V Maddali, June He, Carolyn S. Calfee, Alex K. Lyashchenko, Alison Thompson, John Fountain, Mahesh V. Madhavan, Tejus Satish, David Furfaro, Michael Murn, Max R. O'Donnell, Amanda Rosen, Matthew A Adan, Matthew R. Baldwin, Aakriti Gupta
Publikováno v:
American journal of respiratory and critical care medicine, vol 204, iss 11
American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory and Critical Care Medicine
Rationale Two distinct subphenotypes have been identified in acute respiratory distress syndrome (ARDS), but the presence of subgroups in ARDS associated with COVID-19 is unknown. The objective of this study was to identify clinically relevant, novel
Publikováno v:
British journal of clinical pharmacologyREFERENCES. 89(1)
To investigate the relationship between systemic exposure to hydroxychloroquine (HCQ) and its metabolite desethylhydroxychloroquine (DHCQ) and clinical outcome in severely ill patients treated with a standard oral dose regimen of HCQ during the first
Autor:
Alex K. Lyashchenko, Serge Cremers
Publikováno v:
Br J Clin Pharmacol
Personalization of oral small molecule anticancer drug doses based on individual patient blood drug levels, also known as therapeutic drug monitoring (TDM), has the potential to significantly improve the effectiveness of treatment by maximizing drug
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101236 (2014)
Hyperpolarization-activated cyclic nucleotide-regulated HCN channels underlie the Na+-K+ permeable IH pacemaker current. As with other voltage-gated members of the 6-transmembrane KV channel superfamily, opening of HCN channels involves dilation of a
Externí odkaz:
https://doaj.org/article/15462e58120249e68ad814e9a26b8a75
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1885
In the prenatal quad screen, the levels of four analytes in maternal serum are used to calculate the risk of serious birth defects. The Beckman Access2 Immunoassay System is an automated analyzer that enables rapid measurement of alpha-fetoprotein, u
Publikováno v:
Prenatal Diagnosis ISBN: 9781493988877
In the prenatal quad screen, the levels of four analytes in maternal serum are used to calculate the risk of serious birth defects. The Beckman Access2 Immunoassay System is an automated analyzer that enables rapid measurement of alpha-fetoprotein, u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce4ae6a6f6acd98b2f1b23c5d4666003
https://doi.org/10.1007/978-1-4939-8889-1_20
https://doi.org/10.1007/978-1-4939-8889-1_20
Publikováno v:
Journal of Clinical Apheresis. 32:571-573
Graft-versus-host disease (GVHD) is a complication of allogeneic hematopoietic stem cell transplantation with high morbidity and mortality. Extracorporeal photopheresis (ECP) is an effective therapy for treating medication-refractory GVHD, however, t
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 113(51)
The molecular and cellular basis of selective motor neuron (MN) vulnerability in amyotrophic lateral sclerosis (ALS) is not known. In genetically distinct mouse models of familial ALS expressing mutant superoxide dismutase-1 (SOD1), TAR DNA-binding p
Autor:
Sandeep N. Wontakal, Alex K. Lyashchenko, Alexander Kratz, Eldad A. Hod, Giselle M Reynafarje
Publikováno v:
American Journal of Clinical Pathology. 149:S172-S173
ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function
Autor:
Aarti Sharma, Alex K. Lyashchenko, Juan Carlos Tapia, Sara Ebrahimi Nasrabady, Margot Elmaleh, Neil A. Shneider, George Z. Mentis, Adriana Nemes, Lei Lu, Monica Mendelsohn
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Mutations in FUS cause amyotrophic lateral sclerosis (ALS), including some of the most aggressive, juvenile-onset forms of the disease. FUS loss-of-function and toxic gain-of-function mechanisms have been proposed to explain how mutant FUS leads to m