Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Alex J. Whale"'
Autor:
Andreas Hadjicharalambous, Philip Zegerman, Geylani Can, Alex J. Whale, Jonathan M. Houseley, J. Mark Skehel
Publikováno v:
Wellcome Open Research, Vol 8 (2023)
Background: In eukaryotes, replication stress activates a checkpoint response, which facilitates genome duplication by stabilising the replisome. How the checkpoint kinases regulate the replisome remains poorly understood. The aim of this study is to
Externí odkaz:
https://doaj.org/article/c1551f0907c54050b2cc46ae7dc9d569
Autor:
Csenge Gal, Lakxmi Subramanian, Robin C. Allshire, Karen M Moore, Alex J Whale, Konrad Paszkiewicz, Heather E. Murton, Kevin M. Creamer, Simon K. Whitehall, Sandra Codlin, Jürg Bähler, Nicholas A. Kent, Janet F. Partridge
Publikováno v:
EMBO Reports
Gal, C, Murton, H E, Subramanian, L, Whale, A J, Moore, K M, Paszkiewicz, K, Codlin, S, Bähler, J, Creamer, K M, Partridge, J F, Allshire, R C, Kent, N A & Whitehall, S K 2016, ' Abo1, a conserved bromodomain AAA-ATPase, maintains global nucleosome occupancy and organisation ', EMBO Reports, vol. 17, no. 1, pp. 79-93 . https://doi.org/10.15252/embr.201540476
Gal, C, Murton, H E, Subramanian, L, Whale, A J, Moore, K M, Paszkiewicz, K, Codlin, S, Bähler, J, Creamer, K M, Partridge, J F, Allshire, R C, Kent, N A & Whitehall, S K 2016, ' Abo1, a conserved bromodomain AAA-ATPase, maintains global nucleosome occupancy and organisation ', EMBO Reports, vol. 17, no. 1, pp. 79-93 . https://doi.org/10.15252/embr.201540476
Maintenance of the correct level and organisation of nucleosomes is crucial for genome function. Here, we uncover a role for a conserved bromodomain AAA-ATPase, Abo1, in the maintenance of nucleosome architecture in fission yeast. Cells lacking abo1+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff026580cc269f457127eff006bfddac
https://doi.org/10.15252/embr.201540476
https://doi.org/10.15252/embr.201540476
Publikováno v:
PLoS Biology, Vol 21, Iss 8, p e3002245 (2023)
Caloric restriction increases lifespan and improves ageing health, but it is unknown whether these outcomes can be separated or achieved through less severe interventions. Here, we show that an unrestricted galactose diet in early life minimises chan
Externí odkaz:
https://doaj.org/article/4f6d4bb80def4bfa87bbda24affc2436
Autor:
Andre Zylstra, Hanane Hadj-Moussa, Dorottya Horkai, Alex J Whale, Baptiste Piguet, Jonathan Houseley
Publikováno v:
PLoS Biology, Vol 21, Iss 8, p e3002250 (2023)
The massive accumulation of extrachromosomal ribosomal DNA circles (ERCs) in yeast mother cells has been long cited as the primary driver of replicative ageing. ERCs arise through ribosomal DNA (rDNA) recombination, and a wealth of genetic data conne
Externí odkaz:
https://doaj.org/article/ecfd31e7a1f4495da1dac92fd5ff4fa4