Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Alex J. Shortt"'
Publikováno v:
Current Eye Research. 47:1106-1115
To investigate if human oral mucosal fibroblasts (HOMF) from patients with limbal stem cell deficiency (LSCD) can be used as an autologous feeder layer to support the culture of epithelial cells for potential clinical use.HOMF were isolated from oral
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94283 (2014)
Limbal epithelial stem cells (LESCs) are essential to maintain the transparent ocular surface required for vision. Despite great advances in our understanding of ocular stem cell biology over the last decade, the exact location of the LESC niche rema
Externí odkaz:
https://doaj.org/article/d9685ee4f80f44c58355113485a882dc
Publikováno v:
BMJ Open, Vol 10, Iss 10 (2020)
BMJ Open
BMJ Open
ObjectivesTo understand the incidence, causes, management and outcomes of intentional (assault) and unintentional severe ocular chemical injuries (SOCI) at an urban tertiary referral centre in the UK.DesignRetrospective observational study.SettingA L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5bd2fe8aa439254f4ee95c3e6a0763c
Autor:
Hannah J Levis, Gary S L Peh, Kah-Peng Toh, Rebekah Poh, Alex J Shortt, Rosemary A L Drake, Jodhbir S Mehta, Julie T Daniels
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50993 (2012)
Current treatments for reversible blindness caused by corneal endothelial cell failure involve replacing the failed endothelium with donor tissue using a one donor-one recipient strategy. Due to the increasing pressure of a worldwide donor cornea sho
Externí odkaz:
https://doaj.org/article/8e69f2b0f08c4011854b5f9a302d20c0
Autor:
Harminder S. Dua, Dalia G. Said, Elisabeth M. Messmer, Maurizio Rolando, Jose M. Benitez-del-Castillo, Parwez N. Hossain, Alex J. Shortt, Gerd Geerling, Mario Nubile, Francisco C. Figueiredo, Saaeha Rauz, Leonardo Mastropasqua, Paolo Rama, Christophe Baudouin
Publikováno v:
Progress in Retinal and Eye Research. 66:107-131
Neurotrophic Keratopathy (NK) refers to a condition where corneal epitheliopathy leading to frank epithelial defect with or without stromal ulceration (melting) is associated with reduced or absent corneal sensations. Sensory nerves serve nociceptor
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 16
International Journal of Molecular Sciences, Vol 21, Iss 5849, p 5849 (2020)
Volume 21
Issue 16
International Journal of Molecular Sciences, Vol 21, Iss 5849, p 5849 (2020)
Adipose-derived mesenchymal stromal cells (Ad-MSCs) may alleviate corneal injury through the secretion of therapeutic factors delivered at the injury site. We aimed to investigate the therapeutic factors secreted from hypothermically stored, alginate
Publikováno v:
The Cochrane Library
Background Corneal endothelial transplantation has become the gold standard for the treatment of corneal endothelial dysfunctions, replacing full thickness transplantation, known as penetrating keratoplasty. Corneal endothelial transplantation has be
Autor:
Radhika Sheth, Amanda J. Vernon, Alex J Shortt, Julie T. Daniels, Isobel Massie, Michael H Neale
Publikováno v:
Current Eye Research. 40:1077-1087
To develop a clinical grade fibrin gel for the culture of oral mucosal epithelial cells (OMEC) intended for ocular surface reconstruction in the treatment of limbal stem cell deficiency (LSCD).Transparent fibrin gels composed of fibrinogen and thromb
Autor:
Stephen J Tuft, Caroline J Doré, Amanda J. Vernon, Catey Bunce, Julie T. Daniels, Genevieve A. Secker, Peter Blows, Alex J Shortt, Hannah J. Levis
Publikováno v:
Stem Cells Translational Medicine. 3:265-275
Limbal stem cell deficiency (LSCD) is an eye disorder in which the stem cells responsible for forming the surface skin of the cornea are destroyed by disease. This results in pain, loss of vision, and a cosmetically unpleasant appearance. Many new tr
Publikováno v:
Cochrane Database of Systematic Reviews.