Výsledky vyhledávání - "Alex J. Kiraly"

Effects of a phosphocitrate analogue on osteophyte, subchondral bone advance, and bone marrow lesions in Hartley guinea pigs

Autor: David R. Mauerhan, Alex J. Kiraly, Edward N. Hanley, Michael Cox, Yubo Sun, A. R. Sun

Publikováno v: Bone & Joint Research

Objectives The objectives of this study were: 1) to examine osteophyte formation, subchondral bone advance, and bone marrow lesions (BMLs) in osteoarthritis (OA)-prone Hartley guinea pigs; and 2) to assess the disease-modifying activity of an orally

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7624b93f456ec28afe57b4e80297133d
http://europepmc.org/articles/PMC5895945

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The role of inhibition by phosphocitrate and its analogue in chondrocyte differentiation and subchondral bone advance in Hartley guinea pigs

Autor: David R. Mauerhan, Alex J. Kiraly, Edward N. Hanley, Michael Cox, Yubo Sun

Publikováno v: Experimental and Therapeutic Medicine

Phosphocitrate (PC) and its analogue, PC-β ethyl ester, inhibit articular cartilage degeneration in Hartley guinea pigs. However, the underlying molecular mechanisms remain unclear. The present study aimed to investigate the hypothesis that PC exert

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e7b5a2bc3917cb593db36b51e22e481
http://europepmc.org/articles/PMC5841021

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The Effect of Oral PC-III on Osteoarthritis and Bone Marrow Lesions

Autor: Yubo Sun, A. R. Sun, David R. Mauerhan, Alex J. Kiraly, Edward N. Hanley, S. Talic

Publikováno v: Osteoarthritis and Cartilage. 25:S313-S314

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::684b968f11a8696239acaaa519069818
https://doi.org/10.1016/j.joca.2017.02.525

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A novel aza-anthrapyrazole blocks the progression of experimental autoimmune encephalomyelitis after the priming of autoimmunity

Autor: William T. Gunning, Boyd M. Koffman, Anthony Quinn, Alex J. Kiraly, Sarah Rasche, Miles Hacker

Publikováno v: Clinical Immunology. 141:304-316

Mitoxantrone is one of the few FDA-approved drugs available to treat rapidly progressing forms of multiple sclerosis; however, its utilization is compromised by a cardiotoxic potential and the risk of mitoxantrone-induced leukemia. BBR3378, a novel a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36b444188f87b3ccebb1ca4c04e081d0
https://doi.org/10.1016/j.clim.2011.08.009

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Apigenin inhibits COX-2, PGE2, and EP1 and also initiates terminal differentiation in the epidermis of tumor bearing mice

Autor: Rukiyah Van Dross, Alex J. Kiraly, Audrey Jenkins, Eman Soliman

Publikováno v: Prostaglandins, leukotrienes, and essential fatty acids. 104

Non-melanoma skin cancer (NMSC) is the most prevalent cancer in the United States. NMSC overexpresses cyclooxygenase-2 (COX-2). COX-2 synthesizes prostaglandins such as PGE2 which promote proliferation and tumorigenesis by engaging G-protein-coupled

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52def0f4918e207abf8113060f3e6586
https://pubmed.ncbi.nlm.nih.gov/26802941

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