Výsledky vyhledávání - "Alex J. Holloway"

Akademický článek

Inhibition of caspase pathways limits CD4+ T cell loss and restores host anti-retroviral function in HIV-1 infected humanized mice with augmented lymphoid tissue

Autor: Alex J. Holloway, Tais B. Saito, Kubra F. Naqvi, Matthew B. Huante, Xiuzhen Fan, Joshua G. Lisinicchia, Benjamin B. Gelman, Janice J. Endsley, Mark A. Endsley

Publikováno v: Retrovirology, Vol 21, Iss 1, Pp 1-15 (2024)

Abstract The study of HIV infection and pathogenicity in physical reservoirs requires a biologically relevant model. The human immune system (HIS) mouse is an established model of HIV infection, but defects in immune tissue reconstitution remain a ch

Externí odkaz: https://doaj.org/article/6b210dbcdb27465b8b11fb6325b97717

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Akademický článek

Therapeutic Modulation of Arginase with nor-NOHA Alters Immune Responses in Experimental Mouse Models of Pulmonary Tuberculosis including in the Setting of Human Immunodeficiency Virus (HIV) Co-Infection

Autor: Sadhana Chauhan, Rebecca J. Nusbaum, Matthew B. Huante, Alex J. Holloway, Mark A. Endsley, Benjamin B. Gelman, Joshua G. Lisinicchia, Janice J. Endsley

Publikováno v: Tropical Medicine and Infectious Disease, Vol 9, Iss 6, p 129 (2024)

L-arginine metabolism is strongly linked with immunity to mycobacteria, primarily through the antimicrobial activity of nitric oxide (NO). The potential to modulate tuberculosis (TB) outcomes through interventions that target L-arginine pathways are

Externí odkaz: https://doaj.org/article/fcdde219cac24a639c2dea6cb1679b64

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Combination of Cystatins 9 and C Modulates Serum Biomarkers Associated with Inflammation and Provides Prophylactic as Well as Long-Term Protection against Multidrug-Resistant Klebsiella pneumoniae

Autor: Jieh Juen Yu, Gregg N. Milligan, Tonyia Eaves-Pyles, Alex J. Holloway, Bernard P. Arulanandam

Publikováno v: Antimicrobial Agents and Chemotherapy. 63

We have identified recombinant human cystatins 9 (rCST9) and C (rCSTC) as a combination immunotherapeutic treatment against multidrug-resistant (MDR) New Delhi metallo-β-lactamase-1 (NDM-1)-producing Klebsiella pneumoniae We evaluated the lasting pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8df65ed8f58a73b07e693c556e703700
https://doi.org/10.1128/aac.02519-18

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Combination of Cystatins 9 and C Modulates Serum Biomarkers Associated with Inflammation and Provides Prophylactic as Well as Long-Term Protection against Multidrug-Resistant

Autor: Alex J, Holloway, JiehJuen, Yu, Bernard P, Arulanandam, Gregg N, Milligan, Tonyia D, Eaves-Pyles

Publikováno v: Antimicrobial Agents and Chemotherapy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3376a35fa39c6b9523845ad7d895c637
https://pubmed.ncbi.nlm.nih.gov/30782995

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Cystatins 9 and C as a Novel Immunotherapy Treatment That Protects against Multidrug-Resistant New Delhi Metallo-Beta-Lactamase-1-Producing Klebsiella pneumoniae

Autor: Bernard P. Arulanandam, Alex J. Holloway, Sarah M. Hoskinson, Tonyia Eaves-Pyles, Jieh Juen Yu

Publikováno v: Antimicrobial Agents and Chemotherapy

Multidrug-resistant (MDR) bacterial pneumonia can induce dysregulated pulmonary and systemic inflammation leading to morbidity and mortality. Antibiotics to treat MDR pathogens do not function to modulate the extent and intensity of inflammation and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbd376e414091f5db07b61b3c0fb4b6c
http://europepmc.org/articles/PMC5826106

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