Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Alex J Bott"'
1
Akademický článek
XPRESSyourself: Enhancing, standardizing, and automating ribosome profiling computational analyses yields improved insight into data.
Autor: Jordan A Berg, Jonathan R Belyeu, Jeffrey T Morgan, Yeyun Ouyang, Alex J Bott, Aaron R Quinlan, Jason Gertz, Jared Rutter
Publikováno v: PLoS Computational Biology, Vol 16, Iss 1, p e1007625 (2020)
Ribosome profiling, an application of nucleic acid sequencing for monitoring ribosome activity, has revolutionized our understanding of protein translation dynamics. This technique has been available for a decade, yet the current state and standardiz
Externí odkaz: https://doaj.org/article/c320610a0ea949369e326b30082f3577
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2
Akademický článek
Glutamine synthetase limits β-catenin–mutated liver cancer growth by maintaining nitrogen homeostasis and suppressing mTORC1
Autor: Weiwei Dai, Jianliang Shen, Junrong Yan, Alex J. Bott, Sara Maimouni, Heineken Q. Daguplo, Yujue Wang, Khoosheh Khayati, Jessie Yanxiang Guo, Lanjing Zhang, Yongbo Wang, Alexander Valvezan, Wen-Xing Ding, Xin Chen, Xiaoyang Su, Shenglan Gao, Wei-Xing Zong
Publikováno v: The Journal of Clinical Investigation, Vol 132, Iss 24 (2022)
Glutamine synthetase (GS) catalyzes de novo synthesis of glutamine that facilitates cancer cell growth. In the liver, GS functions next to the urea cycle to remove ammonia waste. As a dysregulated urea cycle is implicated in cancer development, the i
Externí odkaz: https://doaj.org/article/e6e32c682ad14bdb96a55a2eddeab428
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5
Mitochondrial pyruvate supports lymphoma proliferation by fueling a glutamate pyruvate transaminase 2–dependent glutaminolysis pathway
Autor: Peng Wei, Alex J. Bott, Ahmad A. Cluntun, Jeffrey T. Morgan, Corey N. Cunningham, John C. Schell, Yeyun Ouyang, Scott B. Ficarro, Jarrod A. Marto, Nika N. Danial, Ralph J. DeBerardinis, Jared Rutter
Publikováno v: Science Advances. 8
The fate of pyruvate is a defining feature in many cell types. One major fate is mitochondrial entry via the mitochondrial pyruvate carrier (MPC). We found that diffuse large B cell lymphomas (DLBCLs) consume mitochondrial pyruvate via glutamate-pyru
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9726cc1b0459a8a65675503c9b50a120
https://doi.org/10.1126/sciadv.abq0117
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6
SREBP1 regulates mitochondrial metabolism in oncogenic KRAS expressing NSCLC
Autor: Christian F. Ruiz, John D. Haley, John A. Haley, Alex J. Bott, Emily Montal
Publikováno v: FASEB J
Cancer cells require extensive metabolic reprograming in order to provide the bioenergetics and macromolecular precursors needed to sustain a malignant phenotype. Mutant KRAS is a driver oncogene that is well-known for its ability to regulate the ERK
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7a5b3873bae03220bebd4bcdffef12c
https://doi.org/10.1096/fj.202000052r
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7
Maestro of the SereNADe: SLC25A51 Orchestrates Mitochondrial NAD+
Autor: Jared Rutter, Alex J. Bott, Yeyun Ouyang
Publikováno v: Trends in Biochemical Sciences. 46:348-350
Recently, three groups, Girardi et al., Kory et al., and Luongo et al., independently identified solute carrier (SLC) 25A51 as the long-sought, major mitochondrial NAD+ transporter in mammalian cells. These studies not only deorphan an uncharacterize
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::52f05607bb968a838c6998b7fc19a7d3
https://doi.org/10.1016/j.tibs.2021.02.001
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8
Mitochondrial pyruvate supports lymphoma proliferation by fueling a non-canonical glutamine metabolism pathway
Autor: Ahmad A. Cluntun, John C. Schell, Peng Wei, Corey N. Cunningham, Scott B. Ficarro, Ralph J. DeBerardinis, Alex J. Bott, Jeffrey T. Morgan, Jared Rutter, Yeyun Ouyang, Nika N. Danial, Jarrod A. Marto
SUMMARYThe fate of pyruvate, which is modulated by the activity of the mitochondrial pyruvate carrier (MPC), is a defining metabolic feature in many cancers. Diffuse large B-cell lymphomas (DLBCLs) are a genetically and metabolically heterogeneous ca
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2200f30d93c37c79fea3845132dd3c04
https://doi.org/10.1101/2021.08.26.457847
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10
XPRESSyourself: Enhancing, standardizing, and automating ribosome profiling computational analyses yields improved insight into data
Autor: Aaron R. Quinlan, Jordan A. Berg, Jared Rutter, Jonathan R Belyeu, Yeyun Ouyang, Alex J. Bott, Jason Gertz, Jeffrey T. Morgan
Publikováno v: PLoS Computational Biology
PLoS Computational Biology, Vol 16, Iss 1, p e1007625 (2020)
Ribosome profiling, an application of nucleic acid sequencing for monitoring ribosome activity, has revolutionized our understanding of protein translation dynamics. This technique has been available for a decade, yet the current state and standardiz
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaf433783c6ba84f56e95b190b140a59
https://pubmed.ncbi.nlm.nih.gov/32004313
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