Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Alex J Berkowitz"'
Autor:
Elizabeth Geerling, Valerie Murphy, Maria C Mai, E Taylor Stone, Andreu Gazquez Casals, Mariah Hassert, Austin T O'Dea, Feng Cao, Maureen J Donlin, Mohamed Elagawany, Bahaa Elgendy, Vasiliki Pardali, Erofili Giannakopoulou, Grigoris Zoidis, Daniel V Schiavone, Alex J Berkowitz, Nana B Agyemang, Ryan P Murelli, John E Tavis, Amelia K Pinto, James D Brien
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0274266 (2022)
Rift Valley fever virus (RVFV) is a veterinary and human pathogen and is an agent of bioterrorism concern. Currently, RVFV treatment is limited to supportive care, so new drugs to control RVFV infection are urgently needed. RVFV is a member of the or
Externí odkaz:
https://doaj.org/article/f63b08d6f3224485b760c43c8a67f8c2
Autor:
Andreu Gazquez Casals, Alex J. Berkowitz, Alice J. Yu, Hope E. Waters, Daniel V. Schiavone, Diana M. Kapkayeva, Lynda A. Morrison, Ryan P. Murelli
Publikováno v:
RSC Advances. 13:8743-8752
Amide-appended α-hydroxytropolones from a previously described library suppressed herpes simplex virus (HSV) replication in cell culture. A targeted follow-up library led to potent analogs against HSV-1 and -2, including acyclovir-resistant mutants.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::843262290307398d0676a3c04ca458fc
https://doi.org/10.1039/d2ra06749h
https://doi.org/10.1039/d2ra06749h
Autor:
Alex J. Berkowitz, Aswin K. Garimallaprabhakaran, Lynda A. Morrison, Alice J. Yu, Andreu Gazquez Cassals, Abaigeal D. Franson, Katherine A. Donald, Ryan P. Murelli
Publikováno v:
Medchemcomm
We previously reported that troponoid compounds profoundly inhibit replication of herpes simplex virus (HSV)-1 and HSV-2 in cell culture, including acyclovir-resistant mutants. Synthesis of 26 alpha-hydroxylated tropolones (αHTs) led to a preliminar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e439bbfdfc2d6af1d45585fcc4cfcf32
https://doi.org/10.1039/c9md00225a
https://doi.org/10.1039/c9md00225a
Autor:
Juan A. Villa, Qilan Li, Alex J. Berkowitz, Maureen J. Donlin, Americo J. Fraboni, Feng Cao, John P. Stasiak, Daniel V. Schiavone, Emilio Gallicchio, Elena Lomonosova, Lauren P. Bejcek, Rudolf G. Abdelmessih, Brienna Milleson, Austin T O'Dea, Ryan P. Murelli, Anastasiya Lyubimova, John E. Tavis, John-Charles Baucom
Publikováno v:
Antiviral Res
The Hepatitis B Virus (HBV) ribonuclease H (RNaseH) is a promising but unexploited drug target. Here, we synthesized and analyzed a library of 57 amide-containing α-hydroxytropolones (αHTs) as potential leads for HBV drug development. Fifty percent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::729d7b81a152419bd187938d069d3366
https://europepmc.org/articles/PMC7199283/
https://europepmc.org/articles/PMC7199283/
Publikováno v:
Tetrahedron Letters. 59:3026-3028
α-Hydroxytropolones (αHTs) are excellent metalloenzyme-inhibiting fragments that have been the basis for the development of potent inhibitors of various therapeutically important enzymes. The following manuscript describes a final-step amidation ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e54dd5c06c34d1164f4746d8228612a
https://doi.org/10.1016/j.tetlet.2018.06.063
https://doi.org/10.1016/j.tetlet.2018.06.063
Autor:
Anthony Zunica, John E. Tavis, Maureen J. Donlin, Alex J. Berkowitz, Ashlyn Lipnicky, Aswin K. Garimallaprabhakaran, Marvin J. Meyers, Ryan P. Murelli, Alexandre Grigoryan
Publikováno v:
Antimicrobial Agents and Chemotherapy. 61
Cryptococcus neoformans is a pathogen that is common in immunosuppressed patients. It can be treated with amphotericin B and fluconazole, but the mortality rate remains 15 to 30%. Thus, novel and more effective anticryptococcal therapies are needed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36b013399b41c2e0e01e6962d4d3535c
https://doi.org/10.1128/aac.02574-16
https://doi.org/10.1128/aac.02574-16