Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Alex J, Poot"'
Autor:
Leonor Teles, Nelleke Tolboom, Sabine L.A. Plasschaert, Alex J. Poot, Arthur J.A.T. Braat, Max M. van Noesel
Publikováno v:
EJC Paediatric Oncology, Vol 4, Iss , Pp 100203- (2024)
Molecular imaging with positron emission tomography (PET) offers significant potential for improving diagnostic accuracy, staging and treatment monitoring in paediatric solid tumours, by using radiopharmaceuticals more specific than [18F]fluorodeoxyg
Externí odkaz:
https://doaj.org/article/c957bee80bbc48288e68cd4717e83cd2
Autor:
Zijian Ye, Berend van der Wildt, F. Ruben H. A. Nurmohamed, J. Fred F. Hooning van Duyvenbode, Jos van Strijp, H. Charles Vogely, Marnix G. E. H. Lam, Ekaterina Dadachova, Harrie Weinans, Bart C. H. van der Wal, Alex J. Poot
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
BackgroundAddressing prosthetic joint infections poses a significant challenge within orthopedic surgery, marked by elevated morbidity and mortality rates. The presence of biofilms and infections attributed to Staphylococcus aureus (S. aureus) furthe
Externí odkaz:
https://doaj.org/article/7bfa2e55ef9d4af1b1953d7e74f64c8d
Autor:
Antonia A. Högnäsbacka, Alex J. Poot, Christophe Plisson, Jonas Bergare, David R. Bonsall, Stuart P. McCluskey, Lisa A. Wells, Esther Kooijman, Robert C. Schuit, Mariska Verlaan, Wissam Beaino, Guus A. M. S. van Dongen, Danielle J. Vugts, Charles S. Elmore, Jan Passchier, Albert D. Windhorst
Publikováno v:
EJNMMI Research, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Background Mutations in the epidermal growth factor receptor (EGFR) kinase domain are common in non-small cell lung cancer. Conventional tyrosine kinase inhibitors target the mutation site in the ATP binding pocket, thereby inhibiting the re
Externí odkaz:
https://doaj.org/article/625cc69bf6ed4690bf32bf9fa866699c
Autor:
Lonneke Rotteveel, Alex J. Poot, Esther J. M. Kooijman, Robert C. Schuit, Ingrid Schalij, Xiaoqing Sun, Kondababu Kurakula, Chris Happé, Wissam Beaino, Peter ten Dijke, Adriaan A. Lammertsma, Harm Jan Bogaard, Albert D. Windhorst
Publikováno v:
EJNMMI Research, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Transforming growth factor β (TGFβ) activity is perturbed in remodelled pulmonary vasculature of patients with pulmonary arterial hypertension (PAH), cancer, vascular diseases and developmental disorders. Inhibition of TGFβ, which signals
Externí odkaz:
https://doaj.org/article/d4e5834623554ec79cfeb8672ef8eb29
Autor:
Marion Chomet, Maxime Schreurs, Ricardo Vos, Mariska Verlaan, Esther J. Kooijman, Alex J. Poot, Ronald Boellaard, Albert D. Windhorst, Guus AMS van Dongen, Danielle J. Vugts, Marc C. Huisman, Wissam Beaino
Publikováno v:
EJNMMI Research, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Introduction The assessment of ex vivo biodistribution is the preferred method for quantification of radiotracers biodistribution in preclinical models, but is not in line with current ethics on animal research. PET imaging allows for noninv
Externí odkaz:
https://doaj.org/article/4f3ec609f1134052bbce1d4d7d199044
Autor:
Antonia Högnäsbacka, Alex J. Poot, Danielle J. Vugts, Guus A. M. S. van Dongen, Albert D. Windhorst
Publikováno v:
Pharmaceuticals, Vol 15, Iss 4, p 450 (2022)
Multiple small molecule PET tracers have been developed for the imaging of the epidermal growth factor receptor (EGFR). These tracers target the tyrosine kinase (TK) domain of the receptor and have been used for both quantifying EGFR expression and t
Externí odkaz:
https://doaj.org/article/2d2991e893e04fb0869a05e61740c912
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
In theranostics (i.e., therapy and diagnostics) radiopharmaceuticals are used for both therapeutic and diagnostic purposes by targeting one specific tumor receptor. Biologically relevant compounds, e.g., receptor ligands or drugs, are labeled with ra
Externí odkaz:
https://doaj.org/article/f6a14300ffff45efb4a8bb76acc1e577
Publikováno v:
Nuclear Medicine and Biology. :58-64
Biologicals, such as antibodies or antibody-fragments e.g. nanobodies, have changed the landscape of cancer therapy and can be used in combination with traditional cancer treatments. They have been demonstrated to be excellent vehicles for molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ba200b1f3740552a300627fd261a32e
https://doi.org/10.1016/j.nucmedbio.2022.09.001
https://doi.org/10.1016/j.nucmedbio.2022.09.001
Publikováno v:
Molecules, Vol 26, Iss 3, p 764 (2021)
89Zr-radiolabelled proteins functionalised with desferrioxamine B are a cornerstone of diagnostic positron emission tomography. In the clinical setting, 89Zr-labelled proteins are produced manually. Here, we explore the potential of using a microflui
Externí odkaz:
https://doaj.org/article/bd6db6684f0f4b05a321a54d253406f8
Autor:
Bruce van Dijk, J. Fred F. Hooning van Duyvenbode, Lisanne de Vor, F. Ruben H. A. Nurmohamed, Marnix G. E. H. Lam, Alex J. Poot, Ruud M. Ramakers, Sofia Koustoulidou, Freek J. Beekman, Jos van Strijp, Suzan H. M. Rooijakkers, Ekaterina Dadachova, H. Charles Vogely, Harrie Weinans, Bart C. H. van der Wal
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 5
Pages: 4374
International Journal of Molecular Sciences (Online), 24(5)
Volume 24
Issue 5
Pages: 4374
International Journal of Molecular Sciences (Online), 24(5)
Implant infections caused by Staphylococcus aureus are difficult to treat due to biofilm formation, which complicates surgical and antibiotic treatment. We introduce an alternative approach using monoclonal antibodies (mAbs) targeting S. aureus and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7be10d9ecef0655e81a68dab6276bccd