Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Alex Hoose"'
Autor:
Matthew E. Massett, Laura Monaghan, Shaun Patterson, Niamh Mannion, Roderick P. Bunschoten, Alex Hoose, Sandra Marmiroli, Robert M. J. Liskamp, Heather G. Jørgensen, David Vetrie, Alison M. Michie, Xu Huang
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-16 (2021)
Abstract Epigenomic dysregulation is a common pathological feature in human hematological malignancies. H3K9me3 emerges as an important epigenomic marker in acute myeloid leukemia (AML). Its associated methyltransferases, such as SETDB1, suppress AML
Externí odkaz:
https://doaj.org/article/c6caf5a67a024f7385a2936b34f65413
Autor:
Laura Monaghan, Matthew E. Massett, Roderick P. Bunschoten, Alex Hoose, Petrisor-Alin Pirvan, Robert M. J. Liskamp, Heather G. Jørgensen, Xu Huang
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Growing evidence has demonstrated that epigenetic dysregulation is a common pathological feature in human cancer cells. Global alterations in the epigenetic landscape are prevalent in malignant cells across different solid tumors including, prostate
Externí odkaz:
https://doaj.org/article/ab95f53a65d24ebca606b6d13543a3fc
Autor:
James E. Noble, Paula Vila-Gómez, Stephanie Rey, Camilla Dondi, Andrea Briones, Purnank Aggarwal, Alex Hoose, Maryana Baran, Maxim G. Ryadnov
Publikováno v:
ACS Biomaterials Science & Engineering. 9:2584-2595
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c87f311ced27332a478f1cd2765f55e
https://doi.org/10.1021/acsbiomaterials.3c00221
https://doi.org/10.1021/acsbiomaterials.3c00221
Synthetic DNA is of increasing demand across many sectors of research and commercial activities. Engineering biology, therapy, data storage and nanotechnology are set for rapid developments if DNA can be provided at scale and low cost. Stimulated by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43101625813b92c6b9adc5c36193915a
http://hdl.handle.net/10044/1/102060
http://hdl.handle.net/10044/1/102060
Publikováno v:
Biomaterials Science. 9:6807-6812
The emergence of multidrug-resistant bacteria stimulates the search for antimicrobial materials capable of addressing challenges conventional antibiotics fail to address. The ability to target intracellular bacteria remains one of the most fundamenta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cca1996ae93315fefa2afc7762808b15
https://doi.org/10.1039/d1bm01235e
https://doi.org/10.1039/d1bm01235e
Autor:
Alison M. Michie, Xu Huang, David Vetrie, Laura Monaghan, Alex Hoose, Niamh Mannion, Roderick P. Bunschoten, Matthew E. Massett, Shaun David Patterson, Rob M. J. Liskamp, Sandra Marmiroli, Heather G. Jørgensen
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-16 (2021)
Cell Death & Disease
Cell Death & Disease
Epigenomic dysregulation is a common pathological feature in human hematological malignancies. H3K9me3 emerges as an important epigenomic marker in acute myeloid leukemia (AML). Its associated methyltransferases, such as SETDB1, suppress AML leukemog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29006c78f23e4a54d99ede8f7f8c80e5
https://doi.org/10.1038/s41419-021-03738-0
https://doi.org/10.1038/s41419-021-03738-0
Autor:
Andrew G. Jamieson, Piotr Raubo, Michael Shipman, Astrid Knuhtsen, Alex Hoose, Jonathan D. Beadle
Publikováno v:
Organic Letters. 19:3303-3306
Solid-phase peptide synthesis (SPPS) is used to create peptidomimetics in which one of the backbone amide C=O bonds is replaced by a four-membered oxetane ring. The oxetane containing dipeptide building blocks are made in three steps in solution, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::babb05eb350e6e84bff39cd3713eaf90
https://doi.org/10.1021/acs.orglett.7b01466
https://doi.org/10.1021/acs.orglett.7b01466
Autor:
Joana Bittencourt-Silvestre, Petrisor Alin Pirvan, Roderick P. Bunschoten, Rob M. J. Liskamp, Taeju Park, Xu Huang, Heather G. Jørgensen, Matthew E. Massett, Laura Monaghan, Alex Hoose
Publikováno v:
Blood. 134:3756-3756
Epigenetic therapies are emerging as a promising therapeutic strategy for acute myeloid leukemia (AML), exemplified by advances in the development of inhibitors targeting DNMT3A, DOT1L and LSD1. We identified an essential role for the H3K9me3 histone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25ea702b4eb64ae458153a865b668693
https://doi.org/10.1182/blood-2019-125355
https://doi.org/10.1182/blood-2019-125355
Publikováno v:
Tetrahedron Letters. 54:4865-4867
The synthesis of a novel fluoropyridine-containing amino acid from pentafluoropyridine by a nucleophilic substitution process is reported. The orthogonal protecting groups can be manipulated and the fluoropyridine amino acid incorporated into a tripe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::903d32824875dadf432a711041d42e5c
https://doi.org/10.1016/j.tetlet.2013.06.124
https://doi.org/10.1016/j.tetlet.2013.06.124