Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Alex Hiroto"'
Autor:
Won Kyung Kim, Alyssa J. Buckley, Dong-Hoon Lee, Alex Hiroto, Christian H. Nenninger, Adam W. Olson, Jinhui Wang, Zhuo Li, Rajeev Vikram, Yao Mawulikplimi Adzavon, Tak-yu Yau, Yigang Bao, Michael Kahn, Joseph Geradts, Guang-Qian Xiao, Zijie Sun
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Androgen deprivation therapy (ADT) targeting androgen/androgen receptor (AR)- signaling pathways is the main therapy for advanced prostate cancer (PCa). However, ADT eventually fails in most patients who consequently develop castration-resis
Externí odkaz:
https://doaj.org/article/8c69e3a71f664fe7bd43113f313a328f
Autor:
Alex Hiroto, Won Kyung Kim, Ariana Pineda, Yongfeng He, Dong-Hoon Lee, Vien Le, Adam W. Olson, Joseph Aldahl, Christian H. Nenninger, Alyssa J. Buckley, Guang-Qian Xiao, Joseph Geradts, Zijie Sun
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Prostate stromal cells can contribute to prostate tumorigenesis. Here the authors show that the loss of androgen receptor signalling in Gli1-lineage stromal cells diminishes prostate epithelial oncogenic transformation and tumor growth in mouse model
Externí odkaz:
https://doaj.org/article/427aea55475646a3858237aad5344a31
Autor:
Won Kyung Kim, Adam W. Olson, Jiaqi Mi, Jinhui Wang, Dong-Hoon Lee, Vien Le, Alex Hiroto, Joseph Aldahl, Christian H. Nenninger, Alyssa J. Buckley, Robert Cardiff, Sungyong You, Zijie Sun
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Activation of the androgen receptor (AR) through androgen binding is essential for prostate tumorigenesis. Here the authors show that AR activation in a subpopulation of prostatic progenitor cells can initiate prostatic intraepithelial neoplasia form
Externí odkaz:
https://doaj.org/article/41964beab6684388acb4a29f190f0143
Autor:
Nikita M Bajwa, Shina Halavi, Mary Hamer, Bridgette D Semple, Linda J Noble-Haeusslein, Mohsen Baghchechi, Alex Hiroto, Richard E Hartman, André Obenaus
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146886 (2016)
Mild traumatic brain injuries can lead to long-lasting cognitive and motor deficits, increasing the risk of future behavioral, neurological, and affective disorders. Our study focused on long-term behavioral deficits after repeated injury in which mi
Externí odkaz:
https://doaj.org/article/1d471bc09ac443ef8b129791ba536a24
Publikováno v:
Cancer Research. 83:2371-2371
Prostate cancer is the second most common cancer in men worldwide. The current treatment targeting androgen receptor (AR) expressing cells, androgen deprivation therapy (ADT), eventually fails in most prostate cancer patients who consequently develop
Autor:
Joseph Aldahl, Alex Hiroto, Sungyong You, Gerald R. Cunha, Jinhui Wang, Vien Le, Minhyung Kim, Adam Olson, Xiwei Wu, Zijie Sun, Dong-Hoon Lee, Won Kyung Kim
Publikováno v:
Development
Stromal androgen-receptor (AR) action is essential for prostate development, morphogenesis and regeneration. However, mechanisms underlying how stromal AR maintains the cell niche in support of pubertal prostatic epithelial growth are unknown. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a72114db71cfe251180c5d0d0c690f47
https://europepmc.org/articles/PMC8497774/
https://europepmc.org/articles/PMC8497774/
Autor:
Won Kyung Kim, Adam W. Olson, Jiaqi Mi, Jinhui Wang, Dong-Hoon Lee, Vien Le, Alex Hiroto, Joseph Aldahl, Christian H. Nenninger, Alyssa J. Buckley, Robert Cardiff, Sungyong You, Zijie Sun
Publikováno v:
Nature communications. 13(1)
Androgen/androgen receptor (AR) signaling pathways are essential for prostate tumorigenesis. However, the fundamental mechanisms underlying the AR functioning as a tumor promoter in inducing prostatic oncogenesis still remain elusive. Here, we demons
Androgen action in cell fate and communication during prostate development at single-cell resolution
Autor:
Alex Hiroto, Jiaqi Mi, Adam Olson, Xiwei Wu, Vien Le, Jinhui Wang, Hong Zeng, Dong-Hoon Lee, Joseph Aldahl, Won Kyung Kim, Zijie Sun
Publikováno v:
Development
Androgens/androgen receptor (AR)-mediated signaling pathways are essential for prostate development, morphogenesis and regeneration. Specifically, stromal AR signaling has been shown to be essential for prostatic initiation. However, the molecular me
Autor:
Mark Mayford, Alex Hiroto, Justin Pastore, Tyler W. Bailey, John H. Speigel, Alex Corches, Edward Korzus
Fear discrimination is critical for survival, while fear generalization is effective for avoiding dangerous situations. Overgeneralized fear is a typical symptom of anxiety disorders, including generalized anxiety disorder and posttraumatic stress di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97c0ddd8dcb0c6aea8a16f97cc52b274
https://europepmc.org/articles/PMC6324971/
https://europepmc.org/articles/PMC6324971/
Publikováno v:
Neuropharmacology. 99:242-255
Cannabis continues to be the most accessible and popular illicit recreational drug. Whereas current data link adolescence cannabinoid exposure to increased risk for dependence on other drugs, depression, anxiety disorders and psychosis, the mechanism