Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Alex Hajnal"'
Autor:
Tea Kohlbrenner, Simon Berger, Ana Cristina Laranjeira, Tinri Aegerter-Wilmsen, Laura Filomena Comi, Andrew deMello, Alex Hajnal
Publikováno v:
PLoS Biology, Vol 22, Iss 8, p e3002775 (2024)
Germ cell apoptosis in Caenorhabditis elegans hermaphrodites is a physiological process eliminating around 60% of all cells in meiotic prophase to maintain tissue homeostasis. In contrast to programmed cell death in the C. elegans soma, the selection
Externí odkaz:
https://doaj.org/article/73d25ef5b59c4b549ec4aaf422b6de7a
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract hox genes encode a conserved family of homeodomain transcription factors that are essential to determine the identity of body segments during embryogenesis and maintain adult somatic stem cells competent to regenerate organs. In contrast to
Externí odkaz:
https://doaj.org/article/9e95c4da31e64e13b9083fb6d0339826
Publikováno v:
PLoS Genetics, Vol 18, Iss 6, p e1009978 (2022)
The sumoylation (SUMO) pathway is involved in a variety of processes during C. elegans development, such as gonadal and vulval fate specification, cell cycle progression and maintenance of chromosome structure. The ubiquitous expression and pleiotrop
Externí odkaz:
https://doaj.org/article/e87e874b58694a6c90fe7ae7b2bd3ef6
Autor:
Evelyn Lattmann, Ting Deng, Michael Walser, Patrizia Widmer, Charlotte Rexha-Lambert, Vibhu Prasad, Ossia Eichhoff, Michael Daube, Reinhard Dummer, Mitchell P Levesque, Alex Hajnal
Publikováno v:
PLoS Biology, Vol 20, Iss 2, p e3001317 (2022)
Cell invasion is an initiating event during tumor cell metastasis and an essential process during development. A screen of C. elegans orthologs of genes overexpressed in invasive human melanoma cells has identified several components of the conserved
Externí odkaz:
https://doaj.org/article/c15f76bcba1e4fc58f9e9a744f0459e3
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2021)
Cell invasion is defined by the capability of cells to migrate across compartment boundaries established by basement membranes (BMs). The development of complex organs involves regulated cell growth and regrouping of different cell types, which are e
Externí odkaz:
https://doaj.org/article/4032bc44a5204d1983145b78eeef3410
Autor:
Ting Deng, Przemyslaw Stempor, Alex Appert, Michael Daube, Julie Ahringer, Alex Hajnal, Evelyn Lattmann
Publikováno v:
PLoS Genetics, Vol 16, Iss 3, p e1008470 (2020)
Cell invasion allows cells to migrate across compartment boundaries formed by basement membranes. Aberrant cell invasion is a first step during the formation of metastases by malignant cancer cells. Anchor cell (AC) invasion in C. elegans is an excel
Externí odkaz:
https://doaj.org/article/c5ceee8c297f41c095e0a74f2c942e9f
Publikováno v:
eLife, Vol 9 (2020)
The intracellular trafficking of growth factor receptors determines the activity of their downstream signaling pathways. Here, we show that the putative HSP-90 co-chaperone CHP-1 acts as a regulator of EGFR trafficking in C. elegans. Loss of chp-1 ca
Externí odkaz:
https://doaj.org/article/6547b5681f494c389e8254e341f74827
Autor:
Mark G. Sterken, Linda van Bemmelen van der Plaat, Joost A. G. Riksen, Miriam Rodriguez, Tobias Schmid, Alex Hajnal, Jan E. Kammenga, Basten L. Snoek
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 7, Iss 9, Pp 3185-3193 (2017)
The oncogenic Ras/MAPK pathway is evolutionarily conserved across metazoans. Yet, almost all our knowledge on this pathway comes from studies using single genetic backgrounds, whereas mutational effects can be highly background dependent. Therefore,
Externí odkaz:
https://doaj.org/article/2e3a0f384cc3428eb5e15f72c1a88de8
Publikováno v:
PLoS Genetics, Vol 13, Iss 1, p e1006592 (2017)
Density-Enhanced Phosphatase-1 (DEP-1) de-phosphorylates various growth factor receptors and adhesion proteins to regulate cell proliferation, adhesion and migration. Moreover, dep-1/scc1 mutations have been detected in various types of human cancers
Externí odkaz:
https://doaj.org/article/bdf307e92b0f4bb1aafe95b6325ed7f9
Publikováno v:
Bio-Protocol, Vol 5, Iss 11 (2015)
The Caenorhabditis elegans (C. elegans) vulva is a well-established system to study organ development as the molecular mechanisms that govern its formation are conserved in animals. Of special interest is the EGFR/RAS/MAPK signaling pathway that is r
Externí odkaz:
https://doaj.org/article/f59e09f680c64ed3b08f154663f874b3