Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Alex Gutsol"'
Autor:
Reza Salehi, Brandon A. Wyse, Meshach Asare-Werehene, Fereshteh Esfandiarinezhad, Atefeh Abedini, Bo Pan, Yoko Urata, Alex Gutsol, Jose L. Vinas, Sahar Jahangiri, Kai Xue, Yunping Xue, Kevin D. Burns, Barbara Vanderhyden, Julang Li, Yutaka Osuga, Dylan Burger, Seang-Lin Tan, Clifford L. Librach, Benjamin K. Tsang
Publikováno v:
Journal of Ovarian Research, Vol 16, Iss 1, Pp 1-20 (2023)
Abstract Polycystic ovarian syndrome (PCOS) is a complex multi-factorial syndrome associated with androgen excess and anovulatory infertility. In the current study, we investigated the role of dihydrotestosterone-induced exosomal miR-379-5p release i
Externí odkaz:
https://doaj.org/article/a018650fac1c4fa4bc44b5269fea638a
Autor:
Reza Salehi, Meshach Asare-Werehene, Brandon A. Wyse, Atefeh Abedini, Bo Pan, Alex Gutsol, Sahar Jahangiri, Peter Szaraz, Kevin D. Burns, Barbara Vanderhyden, Julang Li, Dylan Burger, Clifford L. Librach, Benjamin K. Tsang
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Polycystic ovarian syndrome (PCOS) is associated with hyperandrogenemia and ovarian antral follicle growth arrest. We have previously demonstrated that androgen-induced exosomal release of miR-379-5p (miR379) from preantral follicle granulosa cells i
Externí odkaz:
https://doaj.org/article/48ea15ae5c404c5db488985e1b41b617
Autor:
Haggag S. Zein, Elias Abou-Samra, Michal Scur, Alex Gutsol, Clayton W. Hall, Bishal Dasgupta, Lara Gharibeh, Turki Abujamel, Daniel Medina-Luna, Gayani S. Gamage, Tessa J. Pelino, Mona Nemer, Mir Munir A. Rahim, Alexander Steinle, Brendon D. Parsons, Andrew P. Makrigiannis
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract The C-type lectin-related protein, Clr-f, encoded by Clec2h in the mouse NK gene complex (NKC), is a member of a family of immune regulatory lectins that guide immune responses at distinct tissues of the body. Clr-f is highly expressed in th
Externí odkaz:
https://doaj.org/article/def7019997cf41cd84054dbbb63b9616
Publikováno v:
PLoS ONE, Vol 18, Iss 12, p e0295284 (2023)
Canagliflozin (CANA) is a sodium-glucose cotransporter 2 (SGLT2) inhibitor with blood glucose lowering effects. CANA also promotes kidney protection in patients with cardiovascular diseases and type 2 diabetes (T2D), as well as in normoglycemic patie
Externí odkaz:
https://doaj.org/article/4c332af801d545ee8e6b7f49680ef27a
Autor:
Reza Salehi, Brandon A. Wyse, Meshach Asare-Werehene, Fereshteh Esfandiarinezhad, Atefeh Abedini, Bo Pan, Yoko Urata, Alex Gutsol, Jose L. Vinas, Sahar Jahangiri, Kai Xue, Yunping Xue, Kevin D. Burns, Barbara Vanderhyden, Julang Li, Yutaka Osuga, Dylan Burger, Seang-Lin Tan, Clifford L. Librach, Benjamin K. Tsang
Polycystic ovarian syndrome (PCOS) is a complex multi-factorial syndrome associated with androgen excess and anovulatory infertility. In the current study, we investigated the role of dihydrotestosterone-induced exosomal miR-379-5p release in determi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17fbcced11faeebd37dc4d23c218cb40
https://doi.org/10.21203/rs.3.rs-2599745/v1
https://doi.org/10.21203/rs.3.rs-2599745/v1
Autor:
Kevin D. Burns, Joseph Zimpelmann, Karishma Tailor, Jose L. Viñas, Matthew Spence, Alex Gutsol, Pearl A. Campbell, Christopher J. Porter, Adrianna Douvris
Publikováno v:
Clinical Science. 134:1887-1909
Female sex protects against development of acute kidney injury (AKI). While sex hormones may be involved in protection, the role of differential gene expression is unknown. We conducted gene profiling in male and female mice with or without kidney is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9c699706c57d225c641bfe4ee39d626
https://doi.org/10.1042/cs20200168
https://doi.org/10.1042/cs20200168
Autor:
Dylan Burger, Christopher R.J. Kennedy, Alex Gutsol, Jean-Francois Thibodeau, Susan J. Robertson, Richard L. Hébert, Jamie Ghossein, Rania Nasrallah, Fengxia Xiao, Kevin D. Burns, Joseph Zimpelmann
Publikováno v:
Laboratory Investigation. 100:414-425
Prostaglandin E2 receptor EP1 (PGE2/EP1) promotes diabetic renal injury, and EP1 receptor deletion improves hyperfiltration, albuminuria, and fibrosis. The role of EP1 receptors in hypertensive kidney disease (HKD) remains controversial. We examined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5e0a7d2b16ed13bcb718a835a56f153
https://doi.org/10.1038/s41374-019-0317-7
https://doi.org/10.1038/s41374-019-0317-7
Autor:
Véronique Cheff, Mayra Trentin-Sonoda, Amélie Blais, Jean-François Thibodeau, Chet E. Holterman, Alex Gutsol, Christopher R. J. Kennedy, Richard L. Hébert
Publikováno v:
PLOS ONE. 18:e0281123
Chronic kidney disease (CKD) is a worldwide health burden with increases risk of end-stage renal function if left untreated. CKD induced in the context of metabolic syndrome (MS) increases risks of hypertension, hyperglycemia, excess body fat and dys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f75fd41e7362ae8f88f7c25a5fc0ddf1
https://doi.org/10.1371/journal.pone.0281123
https://doi.org/10.1371/journal.pone.0281123
Autor:
Haggag S, Zein, Elias, Abou-Samra, Michal, Scur, Alex, Gutsol, Clayton W, Hall, Bishal, Dasgupta, Lara, Gharibeh, Turki, Abujamel, Daniel, Medina-Luna, Gayani S, Gamage, Tessa J, Pelino, Mona, Nemer, Mir Munir A, Rahim, Alexander, Steinle, Brendon D, Parsons, Andrew P, Makrigiannis
Publikováno v:
Scientific reports. 12(1)
The C-type lectin-related protein, Clr-f, encoded by Clec2h in the mouse NK gene complex (NKC), is a member of a family of immune regulatory lectins that guide immune responses at distinct tissues of the body. Clr-f is highly expressed in the kidney;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4a1ea3c2ee46e93ef4561df5f637dea9
https://pubmed.ncbi.nlm.nih.gov/35318366
https://pubmed.ncbi.nlm.nih.gov/35318366
Autor:
Alex Gutsol, Adrianna Douvris, Kevin D. Burns, Jose L. Viñas, Matthew Spence, Joseph Zimpelmann, Pearl A. Campbell, Christopher J. Porter
Publikováno v:
Kidney international. 100(3)
Acute kidney injury (AKI) carries high morbidity and mortality, and effective treatments are lacking. Preclinical models support involvement of micro-RNAs (miRs) in AKI pathogenesis, although effects on the kidney transcriptome are unclear. We previo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d6474a598c024931a07964f442dc55d
https://pubmed.ncbi.nlm.nih.gov/34181969
https://pubmed.ncbi.nlm.nih.gov/34181969