Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Alex Groarke"'
Autor:
Allan Hallett, Alyson Fox, Moh Panesar, Stuart Bevan, Andrew James Culshaw, Elliot Lilley, Peter McIntyre, Mark Nash, Alex Groarke
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 342:389-398
The therapeutic potential of transient receptor potential vanilloid type 1 (TRPV1) antagonists for chronic pain has been recognized for more than a decade. However, preclinical and clinical data revealed that acute pharmacological blockade of TRPV1 p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7c7b12494c82f27318abd147f66bbe7
https://doi.org/10.1124/jpet.112.191932
https://doi.org/10.1124/jpet.112.191932
Autor:
Alyson Fox, Marcus Peacock, Alice Chen, Alex Groarke, Christopher Thomas Brain, Yvonne Loong, Jean-Philippe Courade, Alex Dyson, Mohammed Yaqoob
Publikováno v:
Pain. 116:129-137
CT-3 (ajulemic acid) is a synthetic analogue of a metabolite of Delta9-tetrahydrocannabinol that has reported analgesic efficacy in neuropathic pain states in man. Here we show that CT-3 binds to human cannabinoid receptors in vitro, with high affini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fe613f46011b040446b89c258fb3523
https://doi.org/10.1016/j.pain.2005.03.037
https://doi.org/10.1016/j.pain.2005.03.037
Autor:
Jon K. Chambers, Laura R. Fitzgerald, Shelagh Wilson, Philip G. Szekeres, Nabil Elshourbagy, Usman Shabon, Dulcie B. Schmidt, George M. Dytko, Nicholas A. Evans, Derk J. Bergsma, Robert S. Ames, Kong B. Tan, Henry M. Sarau, Da Yuan Wang, Graeme Milligan, D. Alex Groarke, Peter T. Buckley, Paul R. Murdock, James J. Foley, Parvathi Nuthulaganti
Publikováno v:
Journal of Biological Chemistry. 275:25965-25971
Opiate tolerance and dependence are major clinical and social problems. The anti-opiate neuropeptides FF and AF (NPFF and NPAF) have been implicated in pain modulation as well as in opioid tolerance and may play a critical role in this process, altho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd5cafd790b16038f625a65339c455f1
https://doi.org/10.1074/jbc.m004515200
https://doi.org/10.1074/jbc.m004515200
Autor:
Hart Terance William, Kara McNair, Isabelle Lyothier, Christopher Thomas Brain, Marcus Peacock, Paul R. Coote, and Mohammed Yaqoob, Iain F. James, Luigi La Vecchia, Adam Kesingland, Jiri Zadrobilek, Edward K. Dziadulewicz, Ulrich Schopfer, Werner Huber, Andrew James Culshaw, Adrian J. Fisher, Lee Edwards, Alyson Fox, Portmann Robert, † Cathal O'Farrell, Alex Groarke, Stuart Bevan, Andrew J. Davis, Clive Gentry, Yvonne Loong
Publikováno v:
Journal of medicinal chemistry. 50(16)
Selective activation of peripheral cannabinoid CB1 receptors has the potential to become a valuable therapy for chronic pain conditions as long as central nervous system effects are attenuated. A new class of cannabinoid ligands was rationally design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::777c052cf3636a39c24a8d1a192898f2
https://pubmed.ncbi.nlm.nih.gov/17630726
https://pubmed.ncbi.nlm.nih.gov/17630726
Autor:
Isabelle Lyothier, W. Lee, Alex Dyson, Andrew J. Davis, Mohammed Yaqoob, Glyn Hughes, Hart Terance William, Prafula Copp, Alyson Fox, Peter McIntyre, Stuart Bevan, Max-Peter Seiler, Martin Christiansen, Clive Gentry, Lee Edwards, Andrew James Culshaw, Allan Hallett, Sally Knights, Sadhana Patel, Clare Davis, Moh Panesar, Kaspar Zimmermann, George Paloumbis, Edward K. Dziadulewicz, Andrew McBryde, Hendrikus Eggelte, Alex Groarke, Peter Kotsonis
Publikováno v:
Journal of medicinal chemistry. 49(2)
Vanilloid receptor 1 (VR1, TRPV1) is a cation-selective ion channel that is expressed on primary afferent neurons and is upregulated following inflammation and nerve damage. Blockers of this channel may have utility in the treatment of chronic nocice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5f4c25b4c9d539093bc540c900bdf7d
https://pubmed.ncbi.nlm.nih.gov/16420034
https://pubmed.ncbi.nlm.nih.gov/16420034
Publikováno v:
FEBS letters. 419(1)
A fusion protein was constructed between the porcine alpha2A-adrenoceptor and a pertussis toxin-insensitive (Cys351Gly) form of the alpha subunit of the G protein Gi1. Addition of agonist ligands to membranes of COS-7 cells transiently transfected to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd29fc7e2a47c5165718cf651eb60daf
https://pubmed.ncbi.nlm.nih.gov/9426237
https://pubmed.ncbi.nlm.nih.gov/9426237
Autor:
Edward K. Dziadulewicz, Stuart J. Bevan, Christopher T. Brain, Paul R. Coote, Andrew J. Culshaw, Andrew J. Davis, Lee J. Edwards, Adrian J. Fisher, Alyson J. Fox, Clive Gentry, Alex Groarke, Terance W. Hart, Werner Huber, Iain F. James, Adam Kesingland, Luigi La Vecchia, Yvonne Loong, Isabelle Lyothier, Kara McNair, Cathal O'Farrell
Publikováno v:
Journal of Medicinal Chemistry; Aug2007, Vol. 50 Issue 16, p3851-3856, 6p
Publikováno v:
Biochemical Society Transactions. 21:227S-227S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82fa170e875e70ec9bff773c1c7dc394
https://doi.org/10.1042/bst021227s
https://doi.org/10.1042/bst021227s
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Exploring the dynamics of regulation of G protein-coupled receptors using green fluorescent protein.
Autor:
Milligan, Graeme
Publikováno v:
British Journal of Pharmacology; Oct1999, Vol. 128 Issue 3, p501-510, 10p