Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Alex Goldfarb"'
Autor:
Josiah Fan, Naveen Poonai, Frank Myslik, Gary Joubert, Victor Istasy, Amita Misir, Rob Soegtrop, Alex Goldfarb, M. Columbus, Drew Thompson
Publikováno v:
Section on Emergency Medicine Program.
Purpose Distal forearm fractures are common in children. Although x-rays are the standard of care, obtaining images can painful and time consuming. It is well known that children’s pain in the emergency department (ED) is sub-optimally managed. Poi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29860aee315db78d0b8ec1597858c640
https://doi.org/10.1542/peds.141.1_meetingabstract.353
https://doi.org/10.1542/peds.141.1_meetingabstract.353
Autor:
Josiah Fan, Naveen Poonai, Frank Myslik, Victor Istasy, Alex Goldfarb, Alexander Sasha Dubrovsky, Robert Soegtrop, Gary Joubert, Drew Thompson, M. Columbus, Amita Misir
Publikováno v:
Paediatrics Publications
Objectives Distal forearm fractures are the most common fracture type in children. Point-of-care-ultrasound (POCUS) is increasingly being used and preliminary studies suggest it offers an accurate approach to diagnosis. However, outcomes such as pain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed11c4995da773ab68f058cf38b3bdab
https://ir.lib.uwo.ca/paedpub/70
https://ir.lib.uwo.ca/paedpub/70
Autor:
Arkady Mustaev, Irina Zakeyeva, S. D. Zorov, Vasily Sosunov, Ekaterina Sosunova, Alex Goldfarb, Anatoly Nikolaev, I. A. Bass, Vadim Nikiforov, Konstantin Severinov
Publikováno v:
Nucleic Acids Research
Three conserved aspartate residues in the largest subunit of multisubunit RNA polymerases (RNAPs) coordinate two Mg2+ ions involved in the catalysis of phosphodiester bond synthesis. A structural model based on the stereochemistry of nucleotidyl tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01c5fb630c60e405c72dd9fd2b1c275b
http://europepmc.org/articles/PMC1180743
http://europepmc.org/articles/PMC1180743
Autor:
Alex Goldfarb, Nataliya Korzheva, Katsuhiko S. Murakami, Satish K. Nair, Arkady Mustaev, Seth A. Darst, Elizabeth A. Campbell
Publikováno v:
Cell. 104:901-912
Rifampicin (Rif) is one of the most potent and broad spectrum antibiotics against bacterial pathogens and is a key component of anti-tuberculosis therapy, stemming from its inhibition of the bacterial RNA polymerase (RNAP). We determined the crystal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::544140bee83e8d93e85e16e0b19fded8
https://doi.org/10.1016/s0092-8674(01)00286-0
https://doi.org/10.1016/s0092-8674(01)00286-0
Publikováno v:
FEBS Letters. 454:71-74
The promoter recognition site on the sigma70 initiation factor is shielded from interaction with DNA unless sigma70 is bound to the core component of RNA polymerase (RNAP). It is shown that interaction of sigma70 with the isolated beta' subunit of Es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4bb7fdb9e26cc6e7977d3d48a1ba173
https://doi.org/10.1016/s0014-5793(99)00778-4
https://doi.org/10.1016/s0014-5793(99)00778-4
Autor:
Alex Goldfarb, Marina Litvinenko
The first reports seemed absurd. A Russian dissident, formerly an employee of the KGB and its successor, the FSB, had seemingly been poisoned in a London hotel. As Alexander Litvinenko's condition worsened, however, and he was transferred to hospital
Publikováno v:
Cold Spring Harbor Symposia on Quantitative Biology. 63:337-346
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba00e1c51d0cc3bb6a11124eb685be9
https://doi.org/10.1101/sqb.1998.63.337
https://doi.org/10.1101/sqb.1998.63.337
Autor:
Maxim Kozlov, Vadim Markovtsov, Alex Goldfarb, Ludmila Denissova, Arkady Mustaev, Evgeny Zaychikov
Publikováno v:
Proceedings of the National Academy of Sciences. 94:6641-6645
The Fe 2+ ion that specifically replaces Mg 2+ in the active center of RNA polymerase generates reactive hydroxyl radicals that cause highly localized cleavage of polypeptide chains. Mapping of the cleavage sites revealed the overall architecture of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::541a6c46c6aa9dc81a441d1a3d80e86f
https://doi.org/10.1073/pnas.94.13.6641
https://doi.org/10.1073/pnas.94.13.6641
Publikováno v:
Science. 273:211-217
The elongation of RNA chains during transcription occurs in a ternary complex containing RNA polymerase (RNAP), DNA template, and nascent RNA. It is shown here that elongating RNAP from Escherichia coli can switch DNA templates by means of end-to-end
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dacbea5fa9639119b473a0d6005d0154
https://doi.org/10.1126/science.273.5272.211
https://doi.org/10.1126/science.273.5272.211
Publikováno v:
Proceedings of the National Academy of Sciences. 93:3221-3226
By using a crosslinkable probe incorporated into the 3' terminus of nascent transcript, three sites were mapped in Escherichia coli RNA polymerase that are contacted by the RNA in the productive elongation complex. Two of these sites are in the beta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b66a44b99403c60007010a873647964
https://doi.org/10.1073/pnas.93.8.3221
https://doi.org/10.1073/pnas.93.8.3221