Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Alex Gaither"'
Autor:
Neil A. O’Brien, Martina S. J. McDermott, Dylan Conklin, Tong Luo, Raul Ayala, Suruchi Salgar, Kevin Chau, Emmanuelle DiTomaso, Naveen Babbar, Faye Su, Alex Gaither, Sara A. Hurvitz, Ronald Linnartz, Kristine Rose, Samit Hirawat, Dennis J. Slamon
Publikováno v:
Breast Cancer Research, Vol 22, Iss 1, Pp 1-17 (2020)
Abstract Background Combined targeting of CDK4/6 and ER is now the standard of care for patients with advanced ER+/HER2− breast cancer. However, acquired resistance to these therapies frequently leads to disease progression. As such, it is critical
Externí odkaz:
https://doaj.org/article/2ebab795d742494f80b2463e971ee39c
Autor:
Diana Graus-Porta, William R. Sellers, Francesco Hofmann, Carlos Garcia-Echeverria, David M. Thomas, Thomas Brümmendorf, Kavitha Venkatesan, John E. Monahan, Jason Borawski, L. Alex Gaither, Mickaël Le Douget, Vincent Bordas, Christopher J. Wilson, Zhi Chen, Yun Zhang, Fang Li, Yao Yao, Astrid Pornon, Louise Barys, Moriko Ito, Christelle Stamm, Simon Wöhrle, Audrey Kauffmann, Vito Guagnano
PDF file - 1.4MB, Response to NVP-BGJ398; FGFR pathway modulation by NVP-BGJ398; NVP-BGJ398 - predictive features; FGFR2-c3 mRNA expression in cell lines and FGFR2 DNA copy number in tumors; FGF19 DNA copy number in CCLE cell lines and FGFR3 DNA copy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::055d71ccbe50a65e308a5319a0af558a
https://doi.org/10.1158/2159-8290.22529469
https://doi.org/10.1158/2159-8290.22529469
Autor:
Diana Graus-Porta, William R. Sellers, Francesco Hofmann, Carlos Garcia-Echeverria, David M. Thomas, Thomas Brümmendorf, Kavitha Venkatesan, John E. Monahan, Jason Borawski, L. Alex Gaither, Mickaël Le Douget, Vincent Bordas, Christopher J. Wilson, Zhi Chen, Yun Zhang, Fang Li, Yao Yao, Astrid Pornon, Louise Barys, Moriko Ito, Christelle Stamm, Simon Wöhrle, Audrey Kauffmann, Vito Guagnano
XML file - 99K, Kinase activity and selectivity for NVP-BGJ398; CCLE cell lines sensitive to NVP-BGJ398; GeneSet expression signatures; FGFR genetic alterations and concomitant mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::394b8c19ed3865b26c4b23f7077d34aa
https://doi.org/10.1158/2159-8290.22529463.v1
https://doi.org/10.1158/2159-8290.22529463.v1
Autor:
Diana Graus-Porta, William R. Sellers, Francesco Hofmann, Carlos Garcia-Echeverria, David M. Thomas, Thomas Brümmendorf, Kavitha Venkatesan, John E. Monahan, Jason Borawski, L. Alex Gaither, Mickaël Le Douget, Vincent Bordas, Christopher J. Wilson, Zhi Chen, Yun Zhang, Fang Li, Yao Yao, Astrid Pornon, Louise Barys, Moriko Ito, Christelle Stamm, Simon Wöhrle, Audrey Kauffmann, Vito Guagnano
XML file - 56K, High throughput pharmacological screen of BGJ398 in 517 cancer cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2881a9c58817a03993b13427e5d262a1
https://doi.org/10.1158/2159-8290.22529466.v1
https://doi.org/10.1158/2159-8290.22529466.v1
Autor:
Umamaheswar Duvvuri, Manojkumar A. Puthenveedu, L. Alex Gaither, Jennifer Grandis, Patrick Ha, Jeffery N. Myers, Daisuke Sano, Raja S. Seethala, Carol A. Bertrand, Dong Xiao, Jean Kim, Anke Bill, Chunbo Shao, Daniel J. Shiwarski
PDF file - 133K, Table summarizing the data from Figure 6.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0eb5d31f49b1413fcb88302d38bfd1
https://doi.org/10.1158/1078-0432.22455699
https://doi.org/10.1158/1078-0432.22455699
Autor:
Umamaheswar Duvvuri, Manojkumar A. Puthenveedu, L. Alex Gaither, Jennifer Grandis, Patrick Ha, Jeffery N. Myers, Daisuke Sano, Raja S. Seethala, Carol A. Bertrand, Dong Xiao, Jean Kim, Anke Bill, Chunbo Shao, Daniel J. Shiwarski
PDF file - 132K, TMEM16A expression influences cell size measured via flow cytometry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83cf608103bf8d6aaa30c001d054b977
https://doi.org/10.1158/1078-0432.22455717
https://doi.org/10.1158/1078-0432.22455717
Autor:
Paloma Bragado, Pere Gascon, Joan Albanell, Ana Lluch, Ana Rovira, Elisabet Ametller, Raul Alonso, Núria Moragas, Leire Recalde-Percaz, Laia Serrano, L. Alex Gaither, Anke Bill, Aleix Noguera-Castells, Federico Rojo, Silvia Menéndez, Estel Enreig, Vanesa Almendro, Patricia Jauregui, Anna López-Plana, Gemma Fuster, Mario Mancino, Patricia Fernández-Nogueira
Purpose:Despite the therapeutic success of existing HER2-targeted therapies, tumors invariably relapse. This study aimed at identifying new mechanisms responsible for HER2-targeted therapy resistance.Experimental Design:We have used a platform of HER
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75503a5e3c93200695c9cee440396104
https://doi.org/10.1158/1078-0432.c.6528494
https://doi.org/10.1158/1078-0432.c.6528494
Autor:
Umamaheswar Duvvuri, Manojkumar A. Puthenveedu, L. Alex Gaither, Jennifer Grandis, Patrick Ha, Jeffery N. Myers, Daisuke Sano, Raja S. Seethala, Carol A. Bertrand, Dong Xiao, Jean Kim, Anke Bill, Chunbo Shao, Daniel J. Shiwarski
PDF file - 3718K, TMEM16A shRNA resistant DNA can rescue the expression from the stable shRNA knockdown.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16334cf407a638b594043aca6c7ba9bb
https://doi.org/10.1158/1078-0432.22455714
https://doi.org/10.1158/1078-0432.22455714
Autor:
Umamaheswar Duvvuri, Manojkumar A. Puthenveedu, L. Alex Gaither, Jennifer Grandis, Patrick Ha, Jeffery N. Myers, Daisuke Sano, Raja S. Seethala, Carol A. Bertrand, Dong Xiao, Jean Kim, Anke Bill, Chunbo Shao, Daniel J. Shiwarski
PDF file - 472K, Over expression of TMEM16A in T24 cancer cells decreases motility and invasion.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de0683f6cadb4f590f035bf65b39b4e
https://doi.org/10.1158/1078-0432.22455720.v1
https://doi.org/10.1158/1078-0432.22455720.v1
Autor:
Umamaheswar Duvvuri, Manojkumar A. Puthenveedu, L. Alex Gaither, Jennifer Grandis, Patrick Ha, Jeffery N. Myers, Daisuke Sano, Raja S. Seethala, Carol A. Bertrand, Dong Xiao, Jean Kim, Anke Bill, Chunbo Shao, Daniel J. Shiwarski
PDF file - 78K, TMEM16A expression levels in primary SCCHN does not correlate with the presence of nodal metastases.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23a69be279986580a16e0ee03fa34484
https://doi.org/10.1158/1078-0432.22455729
https://doi.org/10.1158/1078-0432.22455729