Výsledky vyhledávání - "Alex G. Gauthier"

Akademický článek

Modulation of ATM enhances DNA repair in G2/M phase of cell cycle and averts senescence in Fuchs endothelial corneal dystrophy

Autor: Shazia Ashraf, Neha Deshpande, Queenie Cheung, Jeffrey Boakye Asabere, Raymond Jeff Wong, Alex G. Gauthier, Mohit Parekh, Yadav Adhikari, Geetha Melangath, Ula V. Jurkunas

Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)

Abstract Fuchs Endothelial Corneal Dystrophy (FECD) is an aging disorder characterized by expedited loss of corneal endothelial cells (CEnCs) and heightened DNA damage compared to normal CEnCs. We previously established that ultraviolet-A (UVA) light

Externí odkaz: https://doaj.org/article/941be83417c44d5eaca8b6a2d3809160

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Akademický článek

2-O, 3-O desulfated heparin (ODSH) increases bacterial clearance and attenuates lung injury in cystic fibrosis by restoring HMGB1-compromised macrophage function

Autor: Mao Wang, Alex G. Gauthier, Thomas P. Kennedy, Haichao Wang, Uday Kiran Velagapudi, Tanaji T. Talele, Mosi Lin, Jiaqi Wu, LeeAnne Daley, Xiaojing Yang, Vivek Patel, Sung Soo Mun, Charles R. Ashby, Lin L. Mantell

Publikováno v: Molecular Medicine, Vol 27, Iss 1, Pp 1-17 (2021)

Abstract Background High mobility group box 1 protein (HMGB1) is an alarmin following its release by immune cells upon cellular activation or stress. High levels of extracellular HMGB1 play a critical role in impairing the clearance of invading pulmo

Externí odkaz: https://doaj.org/article/751de7d9c34541a58841dbf2cd260d81

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Akademický článek

From nicotine to the cholinergic anti-inflammatory reflex – Can nicotine alleviate the dysregulated inflammation in COVID-19?

Autor: Alex G. Gauthier, Mosi Lin, Jiaqi Wu, Thomas P. Kennedy, Lee-Anne Daley, Charles R. Ashby, Lin L. Mantell

Publikováno v: Journal of Immunotoxicology, Vol 18, Iss 1, Pp 23-29 (2021)

The coronavirus SARS-CoV-2 of 2019 (COVID-19) causes a pandemic that has been diagnosed in more than 70 million people worldwide. Mild-to-moderate COVID-19 symptoms include coughing, fever, myalgia, shortness of breath, and acute inflammatory lung in

Externí odkaz: https://doaj.org/article/3509f4ef45424e97a129709812198ef6

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Akademický článek

The α7 nicotinic acetylcholine receptor agonist GTS-21 improves bacterial clearance in mice by restoring hyperoxia-compromised macrophage function

Autor: Ravikumar A. Sitapara, Alex G. Gauthier, Vivek S. Patel, Mosi Lin, Michelle Zur, Charles R. Ashby, Lin L. Mantell

Publikováno v: Molecular Medicine, Vol 26, Iss 1, Pp 1-13 (2020)

Abstract Background Mechanical ventilation, in combination with supraphysiological concentrations of oxygen (i.e., hyperoxia), is routinely used to treat patients with respiratory distress, such as COVID-19. However, prolonged exposure to hyperoxia c

Externí odkaz: https://doaj.org/article/06e6f460ddf3479f99cc4617353a4274

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Akademický článek

The α7 nicotinic acetylcholine receptor agonist, GTS-21, attenuates hyperoxia-induced acute inflammatory lung injury by alleviating the accumulation of HMGB1 in the airways and the circulation

Autor: Ravikumar A. Sitapara, Alex G. Gauthier, Sergio I. Valdés-Ferrer, Mosi Lin, Vivek Patel, Mao Wang, Ashley T. Martino, Jeanette C. Perron, Charles R. Ashby, Kevin J. Tracey, Valentin A. Pavlov, Lin L. Mantell

Publikováno v: Molecular Medicine, Vol 26, Iss 1, Pp 1-12 (2020)

Abstract Background Oxygen therapy, using supraphysiological concentrations of oxygen (hyperoxia), is routinely administered to patients who require respiratory support including mechanical ventilation (MV). However, prolonged exposure to hyperoxia r

Externí odkaz: https://doaj.org/article/b13b623bd7544973bd280f95bda287a6

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Akademický článek

The Positive Allosteric Modulation of alpha7-Nicotinic Cholinergic Receptors by GAT107 Increases Bacterial Lung Clearance in Hyperoxic Mice by Decreasing Oxidative Stress in Macrophages

Autor: Alex G. Gauthier, Jiaqi Wu, Mosi Lin, Ravikumar Sitapara, Abhijit Kulkarni, Ganesh A. Thakur, Edward E. Schmidt, Jeanette C. Perron, Charles R. Ashby, Lin L. Mantell

Publikováno v: Antioxidants, Vol 10, Iss 1, p 135 (2021)

Supplemental oxygen therapy with supraphysiological concentrations of oxygen (hyperoxia; >21% O2) is a life-saving intervention for patients experiencing respiratory distress. However, prolonged exposure to hyperoxia can compromise bacterial clearanc

Externí odkaz: https://doaj.org/article/91c4de71274745c4875d6f2ec4b577c1

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2-O, 3-O desulfated heparin (ODSH) increases bacterial clearance and attenuates lung injury in cystic fibrosis by restoring HMGB1-compromised macrophage function

Autor: Haichao Wang, Mosi Lin, Uday Kiran Velagapudi, Lee-Anne Daley, Sung Soo Mun, Alex G. Gauthier, Xiaojing Yang, Jiaqi Wu, Charles R. Ashby, Lin L. Mantell, Mao Wang, Vivek Patel, Tanaji T. Talele, Thomas P. Kennedy

Publikováno v: Molecular Medicine, Vol 27, Iss 1, Pp 1-17 (2021)
Molecular Medicine

Background High mobility group box 1 protein (HMGB1) is an alarmin following its release by immune cells upon cellular activation or stress. High levels of extracellular HMGB1 play a critical role in impairing the clearance of invading pulmonary path

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cabe528eb1629d23200485757123275
https://doaj.org/article/751de7d9c34541a58841dbf2cd260d81

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