Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Alex G. Dalecki"'
Autor:
Arthur H. Totten, Cameron L. Crawford, Alex G. Dalecki, Li Xiao, Frank Wolschendorf, Thomas P. Atkinson
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
RationaleMycoplasmas represent important etiologic agents of many human diseases. Due to increasing antimicrobial resistance and slow rate of novel discovery, unconventional methods of drug discovery are necessary. Copper ions are utilized in host mi
Externí odkaz:
https://doaj.org/article/32d907a7db744768be1febc080a79606
Autor:
Alex G. Dalecki, Obdulia Covarrubias-Zambrano, Riana Roberts, Frank Wolschendorf, Tanji Lewis, Tejaswi Shrestha, Fatimah Al-Ibrahim, Stefan H. Bossmann, Hongwang Wang, Sophia Leonard, Aruni P. Malalasekera, Olaf Kutsch, Madumali Kalubowilage, Kayla Eschliman, Azriel Minjarez-Almeida, Man Zhang, Anteneh Tebeje, Anjana Delpe-Acharige
Publikováno v:
ACS Omega, Vol 6, Iss 9, Pp 6088-6099 (2021)
ACS Omega
ACS Omega
A novel series of copper-activatable drugs intended for use against methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA) were synthesized, characterized, and tested against the MSSA strain Newman and the MRSA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::472cc28c77ebb0479781ac5b437c5349
https://doaj.org/article/a49e40a501dc45e99f257d2a54e6684f
https://doaj.org/article/a49e40a501dc45e99f257d2a54e6684f
Autor:
Alex G. Dalecki, Mildred D. Perez, Frank Wolschendorf, Cameron L. Crawford, Kaitlyn Schaaf, Olaf Kutsch
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Multi-drug resistant Staphylococcus aureus, including methicillin-resistant S. aureus (MRSA), has become a worldwide, major health care problem. While initially restricted to clinical settings, drug resistant S. aureus is now one of the key causative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e593af12c3f4dda2f9daa637ba33b69e
http://link.springer.com/article/10.1038/s41598-020-65978-y
http://link.springer.com/article/10.1038/s41598-020-65978-y
Autor:
Whitney Narmore, Sean Ekins, Lynn Rasmussen, Frank Wolschendorf, Olaf Kutsch, Alex G. Dalecki, Robert Bostwick, Kimberley M. Zorn, Nichole A. Tower, Alex M. Clark
One potential source of new antibacterials is through probing existing chemical libraries for copper-dependent inhibitors (CDIs), i.e., molecules with antibiotic activity only in the presence of copper. Recently, our group demonstrated that previousl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9ec3dc90904e3cff355fe477942540d
https://europepmc.org/articles/PMC6467072/
https://europepmc.org/articles/PMC6467072/
Autor:
Frank Wolschendorf, Alex G. Dalecki
Publikováno v:
Journal of Microbiological Methods. 126:30-34
Facing totally resistant bacteria, traditional drug discovery efforts have proven to be of limited use in replenishing our depleted arsenal of therapeutic antibiotics. Recently, the natural anti-bacterial properties of metal ions in synergy with meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::168c7dbf20e269b8dd207dd22414c0b7
https://doi.org/10.1016/j.mimet.2016.04.013
https://doi.org/10.1016/j.mimet.2016.04.013
Autor:
Olaf Kutsch, Kaitlyn Schaaf, Alex G. Dalecki, Aruni P. Malalasekera, Stefan H. Bossmann, Frank Wolschendorf
Publikováno v:
Metallomics. 8:412-421
The continuous rise of multi-drug resistant pathogenic bacteria has become a significant challenge for the health care system. In particular, novel drugs to treat infections of methicillin-resistant Staphylococcus aureus strains (MRSA) are needed, bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c445d060d8718f5e55f92ebabdf511
https://doi.org/10.1039/c6mt00003g
https://doi.org/10.1039/c6mt00003g
Copper is a ubiquitous element in the environment as well as living organisms, with its redox capabilities and complexation potential making it indispensable for many cellular functions. However, these same properties can be highly detrimental to pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f71ce00e20f70033ce1ab968f6f660cb
https://doi.org/10.1016/bs.ampbs.2017.01.007
https://doi.org/10.1016/bs.ampbs.2017.01.007
Publikováno v:
Clinical and Vaccine Immunology. 21:1323-1329
The ficolins are a family of innate pattern recognition molecules that are known to bind acetylated compounds and activate complement through the association of mannose binding lectin (MBL)/ficolin-associated serine proteases (MASPs). Their importanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::070fc81a1a31276f24d16b5d31527b62
https://doi.org/10.1128/cvi.00370-14
https://doi.org/10.1128/cvi.00370-14
Publikováno v:
Journal of Visualized Experiments.
Most pathogenic bacteria are able to form biofilms during infection, but due to the difficulty of manipulating and assessing biofilms, the vast majority of laboratory work is conducted with planktonic cells. Here, we describe a peg plate biofilm assa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db86dc9f92dc9fa552750e1fe3e1618
https://doi.org/10.3791/53925
https://doi.org/10.3791/53925
Autor:
Alex G. Dalecki, Jim Sun, Frank Wolschendorf, Suzanne M. Michalek, Santosh Shah, Olaf Kutsch, Stefan H. Bossmann, Cameron L. Crawford, Aruni P. Malalasekera
Publikováno v:
Antimicrobial agents and chemotherapy. 60(10)
Copper (Cu) ions are likely the most important immunological metal-related toxin utilized in controlling bacterial infections. Impairment of bacterial Cu resistance reduces viability within the host. Thus, pharmacological enhancement of Cu-mediated a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e620ab5012230834c6e7b1c280b0aed
https://pubmed.ncbi.nlm.nih.gov/27431227
https://pubmed.ncbi.nlm.nih.gov/27431227