Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Alex G. Baldwin"'
Autor:
Michael J. D. Daniels, Jack Rivers-Auty, Tom Schilling, Nicholas G. Spencer, William Watremez, Victoria Fasolino, Sophie J. Booth, Claire S. White, Alex G. Baldwin, Sally Freeman, Raymond Wong, Clare Latta, Shi Yu, Joshua Jackson, Nicolas Fischer, Violette Koziel, Thierry Pillot, James Bagnall, Stuart M. Allan, Pawel Paszek, James Galea, Michael K. Harte, Claudia Eder, Catherine B. Lawrence, David Brough
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
NSAID-induced analgesia is typically induced by inhibition of COX enzymes. Here the authors show instead that fenamate NSAIDs inhibit the Nlrp3 inflammasome via an effect on volume-regulated anion channel function and also repurpose these drugs for t
Externí odkaz:
https://doaj.org/article/dca8360eb57c4ee588985f6c192c8a0c
Autor:
Sally Freeman, Izzeddin Alsalahat, Manikandan Kadirvel, Ian J. Stratford, Soraya Alnabulsi, Buthaina Hussein, Richard A. Bryce, Elham Santina, Rachael N. Magwaza, Alex G. Baldwin, Ilaria Russo, Carl H. Schwalbe
Publikováno v:
Alnabulsi, S, Hussein, B, Santina, E, Alsalahat, I, Kadirvel, M, Magwaza, R N, Bryce, R A, Schwalbe, C H, Baldwin, A G, Russo, I, Stratford, I J & Freeman, S 2018, ' Evaluation of analogues of furan-amidines as inhibitors of NQO2 ', Bioorganic & medicinal chemistry letters . https://doi.org/10.1016/j.bmcl.2018.03.025
Inhibitors of the enzyme NQO2 (NRH: quinone oxidoreductase 2) are of potential use in cancer chemotherapy and malaria. We have previously reported that non-symmetrical furan amidines are potent inhibitors of NQO2 and here novel analogues are evaluate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1fefe3aeaedbb824fac418a62e2b723
https://doi.org/10.1016/j.bmcl.2018.03.025
https://doi.org/10.1016/j.bmcl.2018.03.025
Publikováno v:
Medicinal Chemistry Research
Freeman, S & Ledder, R 2018, ' Synthesis and antibacterial activities of enamine derivatives of dehydroacetic acid ', Medicinal Chemistry Research . https://doi.org/10.1007/s00044-017-2110-8
Freeman, S & Ledder, R 2018, ' Synthesis and antibacterial activities of enamine derivatives of dehydroacetic acid ', Medicinal Chemistry Research . https://doi.org/10.1007/s00044-017-2110-8
Dehydroacetic acid is a common pyrone derivative used commercially as an antibacterial and antifungal agent. Based on the synthesis of dehydroacetic acid (1) from N-hydroxysuccinimdyl acetoacetate, a novel series of enamine-based derivatives were syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf2926fd6560456fcb22d98b4883d90c
Publikováno v:
Journal of Medicinal Chemistry. 59:1691-1710
Inflammasomes are high molecular weight complexes that sense and react to injury and infection. Their activation induces caspase-1 activation and release of interleukin-1β, a pro-inflammatory cytokine involved in both acute and chronic inflammatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a25995192a1fafc1ca5dc9f7ed28260
https://doi.org/10.1021/acs.jmedchem.5b01091
https://doi.org/10.1021/acs.jmedchem.5b01091
Autor:
Simon Fox, David Brough, Eric Karran, David Reynolds, Peter J. Atkinson, Hugh Nuthall, Alex G. Baldwin, Dorte Faust, Elena Redondo-Castro, Lee A. Dawson, Andrew Merritt, Janet Brownlees, Sally Freeman
Publikováno v:
Alzheimer's & Dementia. 13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3a5ae424c21a8d5c782fc7db3bede69
https://doi.org/10.1016/j.jalz.2017.06.713
https://doi.org/10.1016/j.jalz.2017.06.713