Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Alex G Hurd"'
Autor:
François Mach, Xiaodong Gu, Steven E. Nissen, Thomas F. Lüscher, Yoon-Mi Chung, Zeneng Wang, Lorenz Räber, Benjamin J Hazen, Bruce S. Levison, Christian M. Matter, Alex G Hurd, Xinmin S. Li, Slayman Obeid, Alan Pratt, David Nanchen, Stanley L. Hazen, Yuping Wu, Lin Li, W.H. Wilson Tang
Publikováno v:
Eur Heart J
Aims Trimethyllysine (TML) serves as a nutrient precursor of the gut microbiota-derived metabolite trimethylamine N-oxide (TMAO) and is associated with incident cardiovascular (CV) events in stable subjects. We examined the relationship between plasm
Autor:
Xiaodong Gu, Stanley L. Hazen, Matthew W Russell, Jennifer A. Buffa, Jose C. Garcia-Garcia, Aldons J. Lusis, Nilaksh Gupta, Jodie Michelle Reed, Sarah M. Skye, Zeneng Wang, Alex G Hurd, Bruce S. Levison, David B. Cody, William T. Barrington, Joseph A. DiDonato, Lin Li, Adam B. Roberts, J. Mark Brown, Ashraf Duzan, Xiaoming Fu, Jennifer M. Lang, Alex J Myers, Weifei Zhu, Suguna Rachakonda, Valentin Gogonea
Publikováno v:
Nature Medicine. 24:1407-1417
Trimethylamine N-oxide (TMAO) is a gut microbiota-derived metabolite that enhances both platelet responsiveness and in vivo thrombosis potential in animal models, and TMAO plasma levels predict incident atherothrombotic event risks in human clinical
Autor:
W.H. Wilson Tang, Stanley L. Hazen, Jaana Hartiala, Yuping Wu, Tomas Cajka, Thomas F. Lüscher, Sarah M. Skye, Adam B. Roberts, Jennifer A. Buffa, Kymberleigh A. Romano, Christopher J. Shahen, Hooman Allayee, Lin Li, Robert L. Kerby, Yi Han, Xiaodong Gu, Xinmin S. Li, Slayman Obeid, Oliver Fiehn, Matthew A. Wagner, Joseph A. DiDonato, Alex G Hurd, Zeneng Wang, Ina Nemet, Federico E. Rey
Publikováno v:
JCI insight, vol 3, iss 6
Using an untargeted metabolomics approach in initial (N = 99 subjects) and replication cohorts (N = 1,162), we discovered and structurally identified a plasma metabolite associated with cardiovascular disease (CVD) risks, N6,N6,N6-trimethyl-L-lysine