Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Alex Flynt"'
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-11 (2021)
Abstract Background RNA interference (RNAi) regulates gene expression in most multicellular organisms through binding of small RNA effectors to target transcripts. Exploiting this process is a popular strategy for genetic manipulation and has applica
Externí odkaz:
https://doaj.org/article/3fd941ebd7564b90836231ec47655739
Autor:
Tharindu A. Ranathunge, Mahesh Loku Yaddehige, Jordan H. Varma, Cameron Smith, Jay Nguyen, Iyanuoluwani Owolabi, Wojciech Kolodziejczyk, Nathan I. Hammer, Glake Hill, Alex Flynt, Davita L. Watkins
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
The challenges faced with current fluorescence imaging agents have motivated us to study two nanostructures based on a hydrophobic dye, 6H-pyrrolo[3,2-b:4,5-b’]bis [1,4]benzothiazine (TRPZ). TRPZ is a heteroacene with a rigid, pi-conjugated structu
Externí odkaz:
https://doaj.org/article/506ab4f68d844a36b1545cdd3fc7a43e
Autor:
Amber M. Paul, Dhiraj Acharya, Biswas Neupane, E. Ashely Thompson, Gabriel Gonzalez-Fernandez, Katherine M. Copeland, Me’Lanae Garrett, Haibei Liu, Mariper E. Lopez, Matthew de Cruz, Alex Flynt, Jun Liao, Yan-Lin Guo, Federico Gonzalez-Fernandez, Parminder J. S. Vig, Fengwei Bai
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
A small percentage of babies born to Zika virus (ZIKV)-infected mothers manifest severe defects at birth, including microcephaly. Among those who appeared healthy at birth, there are increasing reports of postnatal growth or developmental defects. Ho
Externí odkaz:
https://doaj.org/article/5310bdc7f42d485ca368702ff73d98e0
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15546 (2010)
Rod-like structures composed of actin and the actin-binding protein cofilin are found in Alzheimer's disease (AD) patients. However, the mechanisms underlying formation of these structures and their pathological consequences are still largely unknown
Externí odkaz:
https://doaj.org/article/31a0e9274eda4838bb228557c7a3fc9d
RNA interference (RNAi) is mediated by small (20-30 nucleotide) RNAs that are produced by complex processing pathways. In animals, three main classes are recognized: microRNAs (miRNAs), small-interfering RNAs (siRNAs) and piwi-interacting RNAs (piRNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93a705fd3122005ceb15914b8185e79c
https://doi.org/10.1101/2023.05.07.539760
https://doi.org/10.1101/2023.05.07.539760
Autor:
Indika Chandrasiri, Mahesh Loku Yaddehige, Bo Li, Yuzhe Sun, William E. Meador, Austin Dorris, Mohammad Farid Zia, Nathan I. Hammer, Alex Flynt, Jared H. Delcamp, Edward Davis, Alexander Lippert, Davita L. Watkins
Publikováno v:
ACS Applied Polymer Materials. 4:2972-2986
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c0da83403f05763e2a64d2077717dc9
https://doi.org/10.1021/acsapm.1c01131
https://doi.org/10.1021/acsapm.1c01131
Effects of nanoaggregation on isoindigo-based fluorophores for near-infrared bioimaging applications
Autor:
Nicholas E. Sparks, Austin Dorris, Sajith M. Vijayan, Indika Chandrasiri, Mohammad Farid Zia, Alex Flynt, Nathan I. Hammer, Davita L. Watkins
Publikováno v:
Molecular Systems Design & Engineering. 7:906-914
This work provides fascinating insights into NIR fluorophore design and methods to effectively alter the photophysical and morphological properties of the nanoaggregates for bio-imaging purposes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8d04f5a56aa295119aa066921ebd74d
https://doi.org/10.1039/d2me00014h
https://doi.org/10.1039/d2me00014h
Autor:
Christine M. Hamadani, Indika Chandrasiri, Mahesh Loku Yaddehige, Gaya S. Dasanayake, Iyanuoluwani Owolabi, Alex Flynt, Mehjabeen Hossain, Lucy Liberman, Timothy P. Lodge, Thomas A. Werfel, Davita L. Watkins, Eden E. L. Tanner
Publikováno v:
Nanoscale. 14(16)
Linear-dendritic block copolymers (LDBCs) have emerged as promising materials for drug delivery applications, with their hybrid structure exploiting advantageous properties of both linear and dendritic polymers. LDBCs have promising encapsulation eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a93045752856278dfcac2cc0257e3212
https://pubmed.ncbi.nlm.nih.gov/35362493
https://pubmed.ncbi.nlm.nih.gov/35362493
Publikováno v:
Frontiers in Molecular Biosciences. 9
RNAi is an evolutionarily fluid mechanism with dramatically different activities across animal phyla. One major group where there has been little investigation is annelid worms. Here, the small RNAs of the polychaete developmental model Capitella tel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::628e2fcd666576a1a3d3d31e1fc8f99e
https://doi.org/10.3389/fmolb.2022.802814
https://doi.org/10.3389/fmolb.2022.802814
Publikováno v:
Methods Mol Biol
RNA interference (RNAi) is a common eukaryotic gene regulation process driven by small RNA effectors. Mechanisms that govern regulatory small noncoding RNA behavior have been extensively described in only a handful of organisms, which suggests that t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8e2e17bc49396c9e72e4facf7efd76d0
https://pubmed.ncbi.nlm.nih.gov/34495505
https://pubmed.ncbi.nlm.nih.gov/34495505