Výsledky vyhledávání - "Alex Fedinec"

Vasodilator effects of sulforaphane in cerebral circulation: A critical role of endogenously produced hydrogen sulfide and arteriolar smooth muscle KATP and BK channels in the brain

Autor: Alex Fedinec, Daniel T Hoover, Jianxiong Liu, Helena Parfenova

Publikováno v: J Cereb Blood Flow Metab

We investigated the effects of sulforaphane (SFN), an isothiocyanate from cruciferous vegetables, in the regulation of cerebral blood flow using cranial windows in newborn pigs. SFN administered topically (10 µM–1 mM) or systemically (0.4 mg/kg ip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efe271f80d3289b6a378506a44436c48
https://doi.org/10.1177/0271678x19878284

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The cold receptor TRPM8 activation leads to attenuation of endothelium-dependent cerebral vascular functions during head cooling

Autor: Rong Zhang, Massroor Pourcyrous, Jianxiong Liu, Alex Fedinec, Mimily Harsono, Helena Parfenova

Publikováno v: J Cereb Blood Flow Metab

Using the cranial window technique, we investigated acute effects of head cooling on cerebral vascular functions in newborn pigs. Head cooling lowered the rectal and extradural brain temperatures to 34.3 ± 0.6°C and 26.1 ± 0.6°C, respectively. Du

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48e0d9ce712954b6846b5e52097dea32
https://pubmed.ncbi.nlm.nih.gov/34013806

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Preventing harmful effects of epileptic seizures on cerebrovascular functions in newborn pigs: does sex matter?

Autor: Helena Parfenova, Jianxiong Liu, Alex Fedinec, Charles W. Leffler, Massroor Pourcyrous

Publikováno v: Pediatric research

BACKGROUND The potential contribution of sex-related variables to cerebrovascular functions in neonates remains elusive. Newborn piglets provide a translationally relevant model for studying the effects of seizures in the neonatal brain. The present

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::974cd9cb6c52248ce4f73d52f806c272
https://doi.org/10.1038/pr.2017.152

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Astrocyte-produced carbon monoxide and the carbon monoxide donor CORM-A1 protect against cerebrovascular dysfunction caused by prolonged neonatal asphyxia

Autor: Massroor Pourcyrous, Alex Fedinec, Charles W. Leffler, Helena Parfenova, Jianxiong Liu, Shyamali Basuroy

Publikováno v: American journal of physiology. Heart and circulatory physiology. 315(4)

Neonatal asphyxia leads to cerebrovascular disease and neurological complications via a mechanism that may involve oxidative stress. Carbon monoxide (CO) is an antioxidant messenger produced via a heme oxygenase (HO)-catalyzed reaction. Cortical astr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40f3b2402bdce301b9279b9db5415a67
https://pubmed.ncbi.nlm.nih.gov/30028198

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Epileptic seizures cause extended postictal cerebral vascular dysfunction that is prevented by HO-1 overexpression

Autor: Alex Fedinec, Pierluigi Carratù, Dilyara Tcheranova, Charles W. Leffler, Massroor Pourcyrous, Helena Parfenova

Publikováno v: American journal of physiology. Heart and circulatory physiology. 288(6)

The extended postictal state is characterized by neurological problems in patients. Inadequate blood supply to the brain and impaired cerebral autoregulation may contribute to seizure-induced neuronal damage. Recent evidence in newborn pigs indicates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8cad610e547a5bc5c13ca038c14aadd
https://pubmed.ncbi.nlm.nih.gov/15681702

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Endogenous heme oxygenase prevents impairment of cerebral vascular functions caused by seizures

Autor: Charles W. Leffler, Helena Parfenova, Massroor Pourcyrous, Alex Fedinec, Pierluigi Carratù

Publikováno v: Scopus-Elsevier

In newborn pigs, the mechanism of seizure-induced cerebral hyperemia involves carbon monoxide (CO), the vasodilator product of heme catabolism by heme oxygenase (HO). We hypothesized that seizures cause cerebral vascular dysfunction when HO activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0925bd1d88d10072092d1e1da6122f0
https://pubmed.ncbi.nlm.nih.gov/12915392

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Ionotropic glutamate receptors in cerebral microvascular endothelium are functionally linked to heme oxygenase

Autor: Charles W. Leffler, Alex Fedinec, Helena Parfenova

Publikováno v: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 23(2)

Vasodilator effects of glutamate in the cerebral circulation are, in part, mediated by carbon monoxide (CO), which is formed from heme via the heme oxygenase (HO) pathway. The hypothesis addressed was that glutamate receptors (GluRs) in cerebral micr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69610a460d694c47e310a3138003c16f
https://pubmed.ncbi.nlm.nih.gov/12571450

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