CD160-associated CD8 T-cell functional impairment is independent of PD-1 expression.

Autor: Selena Viganò, Riddhima Banga, Florence Bellanger, Céline Pellaton, Alex Farina, Denis Comte, Alexandre Harari, Matthieu Perreau

Publikováno v: PLoS Pathogens, Vol 10, Iss 9, p e1004380 (2014)

Expression of co-inhibitory molecules is generally associated with T-cell dysfunction in chronic viral infections such as HIV or HCV. However, their relative contribution in the T-cell impairment remains unclear. In the present study, we have evaluat

Externí odkaz: https://doaj.org/article/0d4231de15594763a6b82620d3fef77a

A multiplexed high-throughput neutralization assay reveals a lack of activity against multiple variants after SARS-CoV-2 infection

Autor: Florence Pojer, Charlène Raclot, Jérémy Campos, Giuseppe Pantaleo, Priscilla Turelli, Céline Pellaton, Craig Fenwick, Valeria Cagno, Alex Farina, Didier Trono

The detection of SARS-CoV-2-specific antibodies in the serum of an individual indicates prior infection or vaccination. However, it provides limited insight into the protective nature of this immune response. Neutralizing antibodies recognizing the v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e144dd600d088db9a7915b152aa2eae1
https://doi.org/10.1101/2021.04.08.21255150

A Highly Potent Antibody Effective Against SARS-CoV-2 Variants of Concern

Autor: Giuseppe Pantaleo, Pieter Leyssen, Kelvin Lau, Marc Descatoire, Didier Trono, Jérémy Campos, Victor S. Joo, Céline Pellaton, Yves Levy, Florence Pojer, Erica Lana, Alex Farina, Mathilde Foglierini, Caroline S. Foo, Rana Abdelnabi, Roger LeGrand, Laura Vangeel, Priscilla Turelli, Laurent Perez, Flurin Fiscalini, Line Esteves-Leuenberger, Berend Jan Bosch, Volker Thiel, Wenjuan Du, Geertruida M. Veldman, Alessandra Noto, Charlène Raclot, Johan Neyts, Davide Demurtas, Craig Fenwick

Publikováno v: Cell Reports
Fenwick, Craig; Turelli, Priscilla; Perez, Laurent; Pellaton, Céline; Esteves-Leuenberger, Line; Farina, Alex; Campos, Jérémy; Lana, Erica; Fiscalini, Flurin; Raclot, Charlène; Pojer, Florence; Lau, Kelvin; Demurtas, Davide; Descatoire, Marc; Joo, Victor S; Foglierini, Mathilde; Noto, Alessandra; Abdelnabi, Rana; Foo, Caroline S; Vangeel, Laura; ... (2021). A highly potent antibody effective against SARS-CoV-2 variants of concern. Cell reports, 37(2), p. 109814. Cell Press 10.1016/j.celrep.2021.109814
Cell Reports, 37(2). Elsevier Saunders
Cell reports, vol. 37, no. 2, pp. 109814

Control of the ongoing SARS-CoV-2 pandemic is endangered by the emergence of viral variants with increased transmission efficiency, resistance to marketed therapeutic antibodies and reduced sensitivity to vaccine-induced immunity. Here, we screen B c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6af50c5e75adf62b01984d4431929d3
https://doi.org/10.2139/ssrn.3844718

Changes in SARS-CoV-2 Antibody Responses Impact the Estimates of Infections in Population-Based Seroprevalence Studies

Autor: Semira Gonseth Nusslé, Berend Jan Bosch, Alex Farina, Florence Pojer, Kelvin Lau, Giuseppe Pantaleo, David L. Hacker, Céline Pellaton, Cyril Andre, Jérémy Campos, Alix T. Coste, Valerie D'Acremont Genton, Antony Croxatto, Didier Trono, Murielle Bochud, Craig Fenwick, Gilbert Greub

We have determined SARS-CoV-2-specific antibody responses in a cohort of 96 individuals with acute infection and in 578 individuals enrolled in a seroprevalence population study in Switzerland including three groups, i.e. subjects with previous RT-PC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd5196353ad94aca6a9595913cdc3484

Large TCR diversity of virus-specific CD8 T cells provides the mechanistic basis for massive TCR renewal after antigen exposure

Autor: Giuseppe Pantaleo, Selena Vigano, Alexandre Harari, Patrick Taffé, Alex Farina, Angélique Marrau, Isabelle Miconnet

Publikováno v: Journal of immunology (Baltimore Md. : 1950)

Ex vivo analysis of virus-specific CD8 T cell populations by anchored PCR has shown that the CD8 TCR repertoire was less oligoclonal (seven to nine clonotypes per individual epitope) than previously thought. In the current study, TCR diversity was in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11f86d8e21a5be06b82852b1426a516f